Sulindac is a non-steroidal anti-inflammatory drug (NSAID). Like most NSAIDs, sulindac is a non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or COX) inhibitor that acts on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). COX catalyzes the conversion of arachidonic acid to prostaglandin G2 and prostaglandin G2 to prostaglandin H2. Prostaglandin H2 is the precursor of a number of prostaglandins involved in fever, pain, swelling and inflammation. The analgesic, antipyretic and anti-inflammatory effects of sulindac occurs as a result of decreased prostaglandin synthesis.