Pantoprazole Pathway


Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

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References

  1. DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G, & Posey, M.L. (2005). Pharmacotherapy: A pathologic approach. (6 th ed) pp.621-623. New York: McGraw-Hill Medical Publishing Division.
  2. Horn, J. (2000). The proton-pump inhibitors: Similarities and differences. Clinical Therapeutics, 22(3), 266-280. PMID: 10963283
  3. Pantoloc. (2009). [Electronic version]. e-CPS. Retrieved July 1, 2009.