Famotidine Pathway


Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

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References

  1. Bertacinni, G., & Coruzzi, G. (1989). Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics. Pharmacological Research, 21(4), 339-352. PMID: 2570417
  2. Pounder, R.E. (1984). Histamine H2 antagonists and gastric acid secretion. Pharmacology & Therapeutics, 26, 221-234. PMID: 6152495
  3. Shamburek, R.D., & Schubert, M.L. (1993). Pharmacology of gastric acid inhibition. Bailliere’s Clinical Gastroenterology, 7(1), 23-54. PMID: 8097411