Cimetidine Pathway


Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

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References

  1. Bertacinni, G., & Coruzzi, G. (1989). Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics. Pharmacological Research, 21(4), 339-352. PMID: 2570417
  2. Cimetidine. (2009). [Electronic version]. e-CPS. Retrieved July 2, 2009.
  3. Pounder, R.E. (1984). Histamine H2 antagonists and gastric acid secretion. Pharmacology & Therapeutics, 26, 221-234. PMID: 6152495