Nizatidine Pathway


Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin.

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References

  1. Bertacinni, G., & Coruzzi, G. (1989). Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics. Pharmacological Research, 21(4), 339-352. PMID: 2570417
  2. Pounder, R.E. (1984). Histamine H2 antagonists and gastric acid secretion. Pharmacology & Therapeutics, 26, 221-234. PMID: 6152495
  3. Shamburek, R.D., & Schubert, M.L. (1993). Pharmacology of gastric acid inhibition. Bailliere’s Clinical Gastroenterology, 7(1), 23-54. PMID: 8097411