Glucose Transporter Defect (SGLT2)


The major reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and has a Na()-to-glucose coupling ratio of 1:1. This defect causes massive accumulation of glucose in the urine, and symptoms include glucosuria.

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References

  1. Santer, Rene. “Disorders of Glucose Transport”. Blau, N. (2003) Physician’s guide to the laboratory diagnosis of metabolic diseases. (pp 357-358) (2nd ed.) New York: Springer Publishing Company.