Acebutolol Pathway


Acebutolol is a selective β1-receptor antagonist, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range. Activation of β1-receptors by epinephrine increases the heart rate and output. Acebutolol blocks these receptors which lowers the heart rate and blood pressure. In addition, beta blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels.

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References

  1. Apo-acebutolol. (2009). [Electronic version]. e-CPS. Retrieved July 25, 2009.
  2. Borchard, U. (1998). Pharmacological properties of beta-adrenoceptor blocking drugs. Journal of Clinical and Basic Cardiology, 1(1), 5-9.
  3. DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G, & Posey, M.L. (2005). Pharmacotherapy: A pathologic approach. (6 th ed) pp.207-208. New York: McGraw-Hill Medical Publishing Division.