Fluorouracil Pathway


Fluorouracil (5-FU) is a fluoropyrimidine anticancer drug. It exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.

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References

  1. Longley, D.B, Harkin, D.P., and Johnston, P.G. (2003). 5-Fluorouracil: mechanism of action and clinical strategies. Nat Rev Cancer, 3(5), 330-338. PMID: 12724731
  1. Parker, W.B., and Cheng, Y.C. (1990). Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther, 48(3), 381-395. PMID: 1707544