Fluorouracil Pathway

Fluorouracil (5-FU) is a fluoropyrimidine anticancer drug. It exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.

References

1. Longley, D.B, Harkin, D.P., and Johnston, P.G. (2003). 5-Fluorouracil: mechanism of action and clinical strategies. Nat Rev Cancer, 3(5), 330-338. PMID: 12724731

1. Parker, W.B., and Cheng, Y.C. (1990). Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther, 48(3), 381-395. PMID: 1707544