Fluorouracil (5-FU) is a fluoropyrimidine anticancer drug. It exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.
- Longley, D.B, Harkin, D.P., and Johnston, P.G. (2003). 5-Fluorouracil: mechanism of action and clinical strategies. Nat Rev Cancer, 3(5), 330-338. PMID: 12724731
- Parker, W.B., and Cheng, Y.C. (1990). Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther, 48(3), 381-395. PMID: 1707544