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3-oxo-5-alpha-
steroid
4-dehydrogenase 1
Aldo-keto
reductase family
1 member C4
UDP-
glucuronosyltransferase
1-1
Cytochrome P450
19A1
Cytochrome P450
19A1
Cytochrome P450
19A1
Testosterone
17-beta-
dehydrogenase 3
Cytochrome P450
11B1,
mitochondrial
3-oxo-5-beta-
steroid
4-dehydrogenase
UDP-
glucuronosyltransferase
1-1
Corticosteroid
11-beta-
dehydrogenase
isozyme 1
Aldo-keto
reductase family
1 member C4
11b-
Hydroxyandrost-
4-ene-3,17- dione
11b-
Hydroxyandrost-
4-ene-3,17- dione
Androstenedione
NADPH
H
+
Androstanedione
NADP
NADH
H
+
Androsterone
NAD
Uridine
diphosphate
glucuronic acid
Androsterone
glucuronide
Uridine
5'-diphosphate
O
2
19-
Hydroxyandrost-
4-ene-3,17- dione
H
2
O
O
2
19-Oxoandrost-
4-ene-3,17- dione
H
2
O
O
2
Estrone
Formic acid
H
2
O
Testosterone
NAD
NADH
H
+
O
2
H
+
H
2
O
NADPH
H
+
NADP
Etiocholanedione
Etiocholanolone
Uridine
diphosphate
glucuronic acid
Etiocholanolone
glucuronide
Uridine
5'-diphosphate
NADP
NADPH
H
+
Adrenosterone
NADH
H
+
NAD
Heme
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced
flavoprotein
Oxidized
flavoprotein
Reduced adrenal
ferredoxin
Oxidized
adrenal
ferredoxin
Heme
Heme
Heme
Endoplasmic Reticulum
Membrane
Cytosol
SRD5A1
AKR1C4
ERP29
CYP19A1
CYP19A1
CYP19A1
HSD17B3
CYP11B1
AKR1D1
ERP29
HSD11B1
AKR1C4
4AO3D
4AO3D