Guanosine diphosphate
Interaction294
Bepotastine inhibits Histamine + Histamine H1 receptor (Homo sapiens)
Gβ
Q14643
UniProt
Bepotastine H1-Antihistamine Action
Protein kinase C beta type
C04637
KEGG Compound
Inositol 1,4,5-trisphosphate receptor type 1
1.0
Protein kinase C beta type
Endoplasmic Reticulum
937
ChemSpider
Inositol 1,4,5-trisphosphate
51-45-6
CAS
C01245
KEGG Compound
C00035
KEGG Compound
SMILES
NCCC1=CNC=N1
direct_interaction
1,2-Diacyl-sn-glycerol
Inositol 1,4,5-trisphosphate receptor type 1
Histamine
SubPathwayOutput
SMILES
O
Calcium
P05771
UniProt
C00044
KEGG Compound
Water
Guanine nucleotide-binding protein G(q) subunit alpha
1.0
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
Histamine H1 receptor
TransportCatalysis922
ACTIVATION
4.0
Cytoplasm
190786-44-8
CAS
Bepotastine
1.0
P59768
UniProt
Homo sapiens
Reaction101579
false
Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gαq (Homo sapiens) + Gβγ + Histamine + Histamine H1 receptor (Homo sapiens)
LEFT_TO_RIGHT
Reaction100922
false
Water + phosphatidylinositol 4,5-bisphosphate → 1,2-Diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT
Gγ
7732-18-5
CAS
CHEBI:16595
ChEBI
Q9NQ66
UniProt
439456
PubChem-compound
1.0
1.0
85166-31-0
CAS
GO:0005783
GENE ONTOLOGY
Interaction241
Guanosine triphosphate + Gαq (Homo sapiens) activates Phospholipase C, beta 1
774
PubChem-compound
Interaction240
Histamine activates Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens)
2350
PubChem-compound
Interaction243
1,2-Diacyl-sn-glycerol activates protein kinase C beta
Interaction242
Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
Interaction245
protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit
Interaction244
Calcium activates protein kinase C beta
P19838
UniProt
Nuclear factor NF-kappa-B p105 subunit
Inositol 1,4,5-trisphosphate receptor type 1
Guanine nucleotide-binding protein G(q) subunit alpha
8977
PubChem-compound
Inositol 1,4,5-trisphosphate
6830
PubChem-compound
ReactionCatalysis91035
ACTIVATION
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
C10H15N5O11P2
Guanosine diphosphate
443.02432
HMDB0001498
HMDB
SubPathwayInteraction53614
SubPathwayReaction
SubPathway53614Reaction
266
ChemSpider
1.0
Inositol 1,4,5-trisphosphate receptor type 1
1.0
9606
TAXONOMY
962
PubChem-compound
4.0
C10H16N5O14P3
Guanosine triphosphate
522.99066
Guanosine triphosphate
P62873
UniProt
C00076
KEGG Compound
8630
ChemSpider
Gγ
CA%2b2
BioCyc
Mast Cells Release Histamine
SubPathway
GO:0005886
GENE ONTOLOGY
Histamine H1 receptor (Homo sapiens)_Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens)
Ca
Calcium
39.96259
Histamine
1.0
HMDB0002111
HMDB
inositol_1,4,5-trisphosphate
BioCyc
1,2-Diacyl-sn-glycerol
Cell Membrane
CHEBI:15377
ChEBI
P35367
UniProt
6569
ChemSpider
C00001
KEGG Compound
HISTAMINE
BioCyc
271
PubChem-compound
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
1.0
GTP
BioCyc
C00641
KEGG Compound
388562
ChemSpider
HMDB0000464
HMDB
C21H25ClN2O3
Bepotastine
388.15536
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Protein kinase C beta type
1,2-Diacyl-sn-glycerol
P50148
UniProt
Nuclear factor NF-kappa-B p105 subunit
GO:0005634
GENE ONTOLOGY
HMDB0001273
HMDB
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
1.0
HMDB0015600
HMDB
Transport1035
false
Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
1.0
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
CHEBI:18295
ChEBI
Gβγ
HMDB0001201
HMDB
HMDB0000870
HMDB
753
ChemSpider
H2O
Water
18.010565
14127-61-8
CAS
SMILES
[Ca++]
C5H9N3
Histamine
111.07965
phosphatidylinositol 4,5-bisphosphate
86-01-1
CAS
Guanosine triphosphate_Gαq (Homo sapiens)
Nucleus
SMP0060058
SMPDB
Histamine H1 receptor
CHEBI:15996
ChEBI
1.0
Gβ
Calcium
Inositol 1,4,5-trisphosphate receptor type 1
1.0
2260
ChemSpider
C00388
KEGG Compound
PW061004
PathWhiz
SMILES
OC(=O)CCCN1CCC(CC1)OC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
1.0
CHEBI:29108
ChEBI
GO:0005737
GENE ONTOLOGY
146-91-8
CAS
Histamine_Histamine H1 receptor (Homo sapiens)
1.0
phosphatidylinositol 4,5-bisphosphate