Rho-associated protein kinase 1
Gβ
Interaction333
Guanosine triphosphate + Gαi/o inhibits Adenylyl cyclase
Interaction332
Lysophosphatidic acid activates Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens)
Interaction214
Ras activates RAF
Interaction335
Guanosine triphosphate + Gαi/o activates PI3K
Interaction334
Guanosine triphosphate + Gαi/o activates Ras
937
ChemSpider
Interaction216
MEK activates MAPK
Interaction337
RAC-alpha serine/threonine-protein kinase activates NF-κB
Interaction215
RAF activates MEK
Interaction336
PI3K activates RAC-alpha serine/threonine-protein kinase
Inositol 1,4,5-trisphosphate
Interaction339
Guanosine triphosphate + Gα12/13 activates Rho
Interaction338
PI3K activates Rac
Ras
RAF
MEK
direct_interaction
1.0
MEK
MAPK
Serum response factor
Lysophosphatidic acid receptor 1 (Homo sapiens)_Gα_Guanosine diphosphate_Gβγ (Homo sapiens)
SMILES
O
Guanosine triphosphate_Gαq/11
1.0
Interaction340
Rho activates Serum response factor
Interaction342
Guanosine triphosphate + Gαq/11 activates PLC
Interaction341
Rho activates Rho-associated protein kinase 1
Interaction344
Calcium activates PKC
Interaction343
1,2-diacyl-sn-glycerol activates PKC
HMDB0000538
HMDB
Interaction346
Rho-associated protein kinase 1 activates NF-κB
MAPK
Interaction345
PKC activates NF-κB
C00681
KEGG Compound
ATP
BioCyc
1.0
1.0
PW064736
PathWhiz
559142
ChemSpider
TransportCatalysis922
ACTIVATION
C10H12N5O6P
cAMP
329.05252
P59768
UniProt
Gαq/11
1.0
PW000048
PathWhiz
5742
ChemSpider
Gγ
C00575
KEGG Compound
CHEBI:16595
ChEBI
1.0
Q9NQ66
UniProt
85166-31-0
CAS
Guanosine triphosphate
P11831
UniProt
Interaction242
Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1
Inositol 1,4,5-trisphosphate receptor type 1
1.0
5851
ChemSpider
Lysophosphatidic acid
6830
PubChem-compound
C10H15N5O11P2
Guanosine diphosphate
443.02432
Serum response factor
Rho
266
ChemSpider
PPI
BioCyc
C10H16N5O14P3
Guanosine triphosphate
522.99066
Guanosine triphosphate
RAC-alpha serine/threonine-protein kinase
Gγ
Rho-associated protein kinase 1
GO:0005886
GENE ONTOLOGY
SMP0063746
SMPDB
1.0
1.0
inositol_1,4,5-trisphosphate
BioCyc
1,2-diacyl-sn-glycerol
Lysophosphatidic acid
SubPathwayOutput
C00001
KEGG Compound
CHEBI:18361
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
C00002
KEGG Compound
RAC-alpha serine/threonine-protein kinase
388562
ChemSpider
HMDB0000464
HMDB
Guanosine triphosphate_Gα
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Rho
1,2-diacyl-sn-glycerol
Gαi/o
GO:0005634
GENE ONTOLOGY
Reaction110768
false
Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gα + Gβγ + Lysophosphatidic acid + Lysophosphatidic acid receptor 1 (Homo sapiens)
LEFT_TO_RIGHT
4.6.1.1
false
4.6.1.1
Adenosine triphosphate → Pyrophosphate + cAMP
LEFT_TO_RIGHT
CHEBI:17489
ChEBI
1.0
Q92633
UniProt
CAMP
BioCyc
Adenosine triphosphate
C00013
KEGG Compound
HMDB0001201
HMDB
O7P2
Pyrophosphate
173.91193
Q08828
UniProt
Rac
5957
PubChem-compound
14127-61-8
CAS
SMILES
[Ca++]
Gα
CHEBI:15996
ChEBI
56-65-5
CAS
P31749
UniProt
1.0
C6H15O15P3
Inositol 1,4,5-trisphosphate
419.96237
GO:0005737
GENE ONTOLOGY
CHEBI:29108
ChEBI
60-92-4
CAS
PKC
Phospholipid Biosynthesis
SubPathway
cAMP
Guanosine diphosphate
Q14643
UniProt
Inositol 1,4,5-trisphosphate receptor type 1
Lysophosphatidic acid receptor 1
C04637
KEGG Compound
Inositol 1,4,5-trisphosphate receptor type 1
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
2.0
RAF
C00035
KEGG Compound
C01245
KEGG Compound
1,2-diacyl-sn-glycerol
Inositol 1,4,5-trisphosphate receptor type 1
Calcium
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
PI3K
ReactionCatalysis101095
ACTIVATION
C00044
KEGG Compound
Water
Ras
SMILES
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
Rho-associated protein kinase 1
Adenylate cyclase type 1
RAC-alpha serine/threonine-protein kinase
4.0
Cytoplasm
1.0
1.0
Lysophosphatidic acid receptor 1
CHEBI:15422
ChEBI
Homo sapiens
Inositol 1,4,5-trisphosphate
Reaction100922
false
Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate
LEFT_TO_RIGHT
7732-18-5
CAS
Guanosine triphosphate_Gαi/o
Lysophosphatidic acid_Lysophosphatidic acid receptor 1 (Homo sapiens)
439456
PubChem-compound
GO:0005789
GENE ONTOLOGY
1.0
Inositol 1,4,5-trisphosphate receptor type 1
SMP0000025
SMPDB
GO:0005783
GENE ONTOLOGY
Gα12/13
C10H16N5O13P3
Adenosine triphosphate
506.99576
8977
PubChem-compound
Adenylate cyclase type 1
ReactionCatalysis91035
ACTIVATION
Pyrophosphate
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
HMDB0001498
HMDB
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
1.0
9606
TAXONOMY
962
PubChem-compound
1.0
P62873
UniProt
PLC
C00076
KEGG Compound
8630
ChemSpider
CA%2b2
BioCyc
Rho-associated protein kinase 1
HMDB0000058
HMDB
Ca
Calcium
39.96259
HMDB0002111
HMDB
Cell Membrane
CHEBI:15377
ChEBI
6569
ChemSpider
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
2.0
271
PubChem-compound
CHEBI:17552
ChEBI
GTP
BioCyc
1.0
C00641
KEGG Compound
HMDB0001273
HMDB
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
SubPathwayInteraction57757
SubPathway57757Reaction
SubPathwayReaction
Transport1035
false
Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
4.0
644102
PubChem-compound
Rho-associated protein kinase 1
PI3K
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
NF-κB
Rac
Rho
PLC
Adenylyl cyclase
PKC
Gβγ
H2O
Water
18.010565
NF-κB
86-01-1
CAS
phosphatidylinositol 4,5-bisphosphate
Nucleus
Q13464
UniProt
6076
PubChem-compound
Gβ
1.0
Calcium
Lysophosphatidic acid
Guanosine triphosphate_Gα12/13
PKC
1.0
Gα
Gαi/o
1.0
Gαq/11
146-91-8
CAS
Gα12/13
Adenylyl cyclase
1.0
1.0
phosphatidylinositol 4,5-bisphosphate
Lysophosphatidic Acid LPA1 Signalling