Rho-associated protein kinase 1
Guanosine diphosphate
Gβ
Interaction333
Guanosine triphosphate + Gαi/o inhibits Adenylyl cyclase
Interaction214
Ras activates RAF
Interaction335
Guanosine triphosphate + Gαi/o activates PI3K
Interaction334
Guanosine triphosphate + Gαi/o activates Ras
2.0
Interaction216
MEK activates MAPK
Interaction337
RAC-alpha serine/threonine-protein kinase activates NF-κB
Interaction215
RAF activates MEK
Interaction336
PI3K activates RAC-alpha serine/threonine-protein kinase
RAF
Interaction339
Guanosine triphosphate + Gα12/13 activates Rho
Interaction338
PI3K activates Rac
Ras
RAF
MEK
C00035
KEGG Compound
direct_interaction
1.0
MEK
MAPK
Serum response factor
1.0
Q5JWF2
UniProt
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
Interaction340
Rho activates Serum response factor
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Interaction341
Rho activates Rho-associated protein kinase 1
PI3K
ReactionCatalysis101095
ACTIVATION
HMDB0000538
HMDB
Interaction346
Rho-associated protein kinase 1 activates NF-κB
C00044
KEGG Compound
MAPK
C00681
KEGG Compound
ATP
BioCyc
Interaction349
Gαs activates Adenylyl cyclase
Ras
1.0
Rho-associated protein kinase 1
Adenylate cyclase type 1
RAC-alpha serine/threonine-protein kinase
1.0
P43657
UniProt
559142
ChemSpider
Cytoplasm
1.0
C10H12N5O6P
cAMP
329.05252
1.0
P59768
UniProt
1.0
CHEBI:15422
ChEBI
1.0
Interaction353
Lysophosphatidic acid activates Gα + Guanosine diphosphate + Gβγ (Homo sapiens) + Lysophosphatidic acid receptor 6 (Homo sapiens)
PW000048
PathWhiz
Homo sapiens
5742
ChemSpider
Gγ
C00575
KEGG Compound
Gα_Guanosine diphosphate_Gβγ (Homo sapiens)_Lysophosphatidic acid receptor 6 (Homo sapiens)
Guanosine triphosphate_Gαi/o
1.0
Lysophosphatidic acid_Lysophosphatidic acid receptor 6 (Homo sapiens)
1.0
SMP0000025
SMPDB
Guanosine triphosphate
Gα12/13
P11831
UniProt
C10H16N5O13P3
Adenosine triphosphate
506.99576
Lysophosphatidic acid receptor 6
5851
ChemSpider
1.0
8977
PubChem-compound
Adenylate cyclase type 1
6830
PubChem-compound
Lysophosphatidic acid
Pyrophosphate
Serum response factor
C10H15N5O11P2
Guanosine diphosphate
443.02432
Rho
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
SMP0063759
SMPDB
PPI
BioCyc
9606
TAXONOMY
C10H16N5O14P3
Guanosine triphosphate
522.99066
SubPathwayInteraction57762
SubPathway57762Reaction
SubPathwayReaction
Guanosine triphosphate
P62873
UniProt
RAC-alpha serine/threonine-protein kinase
8630
ChemSpider
Gγ
Rho-associated protein kinase 1
Rho-associated protein kinase 1
Adenylyl cyclase
HMDB0000058
HMDB
GO:0005886
GENE ONTOLOGY
Lysophosphatidic Acid LPA6 Signalling
Lysophosphatidic acid receptor 6
Cell Membrane
Lysophosphatidic acid
SubPathwayOutput
6569
ChemSpider
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
2.0
CHEBI:18361
ChEBI
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
GTP
BioCyc
1.0
C00002
KEGG Compound
RAC-alpha serine/threonine-protein kinase
Guanosine triphosphate_Gα
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Rho
Gαi/o
GO:0005634
GENE ONTOLOGY
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
HMDB0001273
HMDB
4.6.1.1
false
4.6.1.1
Adenosine triphosphate → Pyrophosphate + cAMP
LEFT_TO_RIGHT
CHEBI:17489
ChEBI
644102
PubChem-compound
1.0
CAMP
BioCyc
Rho-associated protein kinase 1
Adenosine triphosphate
PI3K
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
NF-κB
Rac
Rho
Adenylyl cyclase
Gβγ
C00013
KEGG Compound
HMDB0001201
HMDB
O7P2
Pyrophosphate
173.91193
Q08828
UniProt
Rac
PW064749
PathWhiz
NF-κB
5957
PubChem-compound
86-01-1
CAS
Nucleus
Gα
Q13464
UniProt
6076
PubChem-compound
CHEBI:15996
ChEBI
Gβ
Lysophosphatidic acid
Guanosine triphosphate_Gα12/13
56-65-5
CAS
Gα
P31749
UniProt
Gαi/o
GO:0005737
GENE ONTOLOGY
1.0
Gα12/13
146-91-8
CAS
60-92-4
CAS
Adenylyl cyclase
Reaction110774
false
Gα + Guanosine diphosphate + Gβγ (Homo sapiens) + Lysophosphatidic acid receptor 6 (Homo sapiens) → Guanosine triphosphate + Gα + Gβγ + Lysophosphatidic acid + Lysophosphatidic acid receptor 6 (Homo sapiens)
LEFT_TO_RIGHT
1.0
Phospholipid Biosynthesis
SubPathway
cAMP