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Delta(24)-
sterol
reductase
Lanosterol
14-alpha
demethylase
Lanosterol
14-alpha
demethylase
Lanosterol
14-alpha
demethylase
Lamin-B
receptor
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
3-beta-
hydroxysteroid-
Delta(8),Delta(7)-
isomerase
Lathosterol
oxidase
7-
dehydrocholesterol
reductase
Sterol-4-
alpha-
carboxylate 3-
dehydrogenase,
decarboxylating
3-keto-steroid
reductase
Sterol-4-
alpha-
carboxylate 3-
dehydrogenase,
decarboxylating
3-keto-steroid
reductase
NADPH
H
+
Lanosterol
NADP
24,25-Dihydrolanosterol
FMNH2
O
2
Formic acid
Flavin Mononucleotide
H
2
O
H
+
4,4-dimethyl-14α-
hydroxymethyl-5α-cholesta-8-
en-3β-ol
FMNH2
O
2
4,4-Dimethyl-14α-formyl-5α-
cholest-8-en-3β-ol
Flavin Mononucleotide
H
2
O
Formic acid
H
+
FMNH2
O
2
4,4-Dimethyl-5α-cholesta-
8,14-dien-3β-ol
Flavin Mononucleotide
Formic acid
H
2
O
H
+
NADPH
H
+
4,4-Dimethyl-5a-cholesta-8-
en-3b-ol
NADP
Fe2+
H
+
O
2
4α-Hydroxymethyl-4β-methyl-
5α-cholesta-8-en-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4α-Formyl-4β-methyl-5α-
cholesta-8-en-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4α-Carboxy-4β-methyl-5α-
cholesta-8-en-3β-ol
Fe3+
H
2
O
4α-methyl-5α-cholesta-8-en-
3-ol
Fe2+
H
+
O
2
4α-hydroxymethyl-5α-
cholesta-8-en-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4α-Formyl-5α-cholesta-8-en-
3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4α-Carboxy-5α-cholesta-8-en-
3β-ol
Fe3+
H
2
O
5a-Cholest-8-en-3b-ol
Lathosterol
Fe2+
H
+
O
2
7-Dehydrocholesterol
Fe3+
H
2
O
NADPH
H
+
Cholesterol
NADP
NADP
4α-methyl-5α-cholesta-8-en-
3-one
NADPH
CO
2
NADPH
H
+
NADP
NADP
5α-cholesta-8-en-3-one
NADPH
H
+
H
+
NADPH
NADP
Iron
Mevalonate
Pathway
Heme
Heme
Iron
Iron
Iron
Iron
Iron
FAD
Heme
Iron
Plasma Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum
Membrane
Inner Nuclear Membrane
Nucleus
Outer Nuclear Membrane