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Ras-related C3 botulinum toxin substrate 1 Sodium/nucleoside cotransporter 2 Solute carrier family 28 member 3 Sodium/nucleoside cotransporter 1 Hypoxanthine- guanine phosphoribosyltransferase Thiopurine S- methyltransferase Multidrug resistance- associated protein 5 Multidrug resistance- associated protein 4 Thioguanosine 5'-triphosphate Thiodeoxyguanosine-5'- triphosphate Thioguanine Thioguanine Na+ Na+ Na+ Na+ Na+ Na+ Phosphoribosyl pyrophosphate 6-Thioguanosine monophosphate PPi S- Adenosylmethionine Methyl- thioguanosine monophosphate S- Adenosylhomocysteine Thioguanosine 5'-diphosphate Thiodeoxyguanosine 5'-diphosphate 1- phosphatidyl- 1D-myo- inositol 4-phosphate ATP H2O 6-Thioguanosine monophosphate ADP Pi ATP H2O ADP Pi 6-Thioguanosine monophosphate Magnesium DNA Synthesis RNA Synthesis Regulation of Apoptosis of Activated T Cells Cytosol Thioguanine is transported into cells after being absorbed through GI tract and delivered through the vasculature system. Thioguanine is converted to 6-thioguanosine monophosphate, which is a metabolite from the mercaptopurine metabolic pathway. Thioguanine can be exported by anticancer resistance transporters. Extracellular Space Thiodeoxyguanosine-5'- triphosphate can be incorporated into DNA. This creates unusable DNA that cannot be replicated or transcripted. Thioguanosine 5'-triphosphate can be incorporated into RNA creating unusable RNA that can't be translated into proteins. Thioguanosine 5'-triphosphate also inhibits ras-related C3 botulinum toxin substrate 1 which is a small GTPase membrane protein that regulates many cellular events such as proliferation, cell to cell adhesion, apoptosis and more. Most importantly it regulates the apoptosis of T and B lymphocytes. With it's inhibition, T and B lymphocytes undergo apoptosis causing immunosuppression.
RAC1 SLC28A2 SLC28A3 SLC28A1 HPRT1 TPMT ABCC5 ABCC4 Thioguanosine 5'-triphosphate Thiodeoxyguanosine- 5'- triphosphate Thioguanine Thioguanine Sodium Sodium Sodium Sodium Sodium Sodium Phosphoribosyl pyrophosphate 6-Thioguanosine monophosphate Pyrophosphate S- Adenosylmethionine Methyl- thioguanosine monophosphate S- Adenosylhomocysteine Thioguanosine 5'-diphosphate Thiodeoxyguanosine 5'-diphosphate 1- phosphatidyl- 1D-myo- inositol 4-phosphate Adenosine triphosphate Water 6-Thioguanosine monophosphate Adenosine diphosphate Phosphate Adenosine triphosphate Water Adenosine diphosphate Phosphate 6-Thioguanosine monophosphate DNA Synthesis RNA Synthesis Regulation of Apoptosis of Activated T Cells