Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
Nucleus
Malonylated
Glyceraldehyde-
3-phosphate
dehydrogenase
Tumor necrosis
factor
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Voltage-
dependent
anion-selective
channel protein
2
Pyruvate
carboxylase,
mitochondrial
Tricarboxylate
transport
protein,
mitochondrial
Voltage-
dependent
anion-selective
channel protein
1
Nuclear pore
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Voltage-
dependent
anion-selective
channel protein
2
Pyruvate
carboxylase,
mitochondrial
Tricarboxylate
transport
protein,
mitochondrial
Voltage-
dependent
anion-selective
channel protein
1
Nuclear pore
Aconitate
hydratase,
mitochondrial
Malate
dehydrogenase,
mitochondrial
Fumarate
hydratase,
mitochondrial
Succinyl-CoA
ligase
[ADP/GDP-
forming]
subunit alpha,
mitochondrial
Succinyl-CoA
ligase
[GDP-forming]
subunit beta,
mitochondrial
Probable
2-oxoglutarate
dehydrogenase
E1 component
DHKTD1,
mitochondrial
Dihydrolipoyllysine-
residue
succinyltransferase
component of
2-oxoglutarate
dehydrogenase
complex,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
citrate
synthase
Pyruvate
dehydrogenase
E1 component
subunit alpha,
somatic form,
mitochondrial
Dihydrolipoyllysine-
residue
acetyltransferase
component of
pyruvate
dehydrogenase
complex,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
Aconitate
hydratase,
mitochondrial
Cis-aconitate
decarboxylase
ATP-citrate
synthase
Acetyl-CoA
carboxylase 1
Fatty acid
synthase
Malate
dehydrogenase,
cytoplasmic
NADP-dependent
malic enzyme
Nitric oxide
synthase,
inducible
NADPH oxidase 4
ATP-citrate
synthase
Acetyl-CoA
carboxylase 1
Interleukin-6
Interleukin-10
Pyruvate
dehydrogenase
E1 component
subunit alpha,
somatic form,
mitochondrial
Dihydrolipoyllysine-
residue
acetyltransferase
component of
pyruvate
dehydrogenase
complex,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
ATP-citrate
synthase
Acetyl-CoA
carboxylase 1
Fatty acid
synthase
Glyceraldehyde-
3-phosphate
dehydrogenase
D-Glucose
pyruvate
Prostaglandin
E2
NO
Malonyl-CoA
Acetyl-CoA
D-Glucose
pyruvate
Acetyl-CoA
Citrate
Acetyl-CoA
D-Glucose
pyruvate
pyruvate
Citrate
Citrate
Citrate
Acetyl-CoA
D-Glucose
pyruvate
pyruvate
Citrate
Citrate
Acetyl-CoA
cis-Aconitic
acid
H
2
O
Malate
NAD
Oxaloacetate
NADH
H
+
Fumaric acid
H
2
O
Succinic acid
ATP
CoA
Succinyl-CoA
ADP
P
i
Oxoglutaric
acid
NAD
CoA
NADH
H
+
CO
2
Isocitric acid
NAD
CO
2
NADH
H
+
Acetyl-CoA
H
2
O
CoA
CoA
NADP
CO
2
NADPH
Hydroquinone
Quinone
H
2
O
Itaconic acid
CO
2
ATP
CoA
Acetyl-CoA
ADP
Oxaloacetate
P
i
ATP
HCO
3
-
Malonyl-CoA
ADP
P
i
NADPH
Acetyl-CoA
CoA
H
2
O
NADP
CO
2
Malate
NAD
NADH
H
+
NADP
CO
2
NADPH
pyruvate
H
+
O
2
L-Arginine
Citrulline
NADP
H
2
O
ATP
CoA
ADP
Oxaloacetate
P
i
ATP
HCO
3
-
ADP
P
i
CoA
NADP
CO
2
NADPH
ATP
CoA
ADP
Oxaloacetate
P
i
ATP
HCO
3
-
Malonyl-CoA
ADP
P
i
NADPH
Acetyl-CoA
CoA
H
2
O
NADP
CO
2
Biotin
Manganese
Biotin
Manganese
Magnesium
FAD
2Fe-2S
4Fe-4S
Biotin
Manganese
Manganese
Heme
FAD
Flavin
Mononucleotide
Tetrahydrobiopterin
Biotin
Manganese
Biotin
Manganese
Pyruvate
dehydrogenase
E1 component
subunit beta,
mitochondrial
Long chain
fatty acid
Reactive oxygen
species
Long chain
fatty acid
Lipoamide
FAD
TNFα
IL-6
IL-10
TNFα
Glycolysis
Prostaglandin
Synthesis
Inflammation
Inflammation
Malonylation
Protein
translation
Acetylation of
histone and
non-histone
proteins
Glycolysis
Citric Acid
Cycle
Membrane
expansion
Acetylation of
histone and
non-histone
proteins