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Solute carrier family 22 member 1 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Canalicular multispecific organic anion transporter 2 Unknown Unknown Cytochrome P450 2B6 UDP- glucuronosyltransferase 1-8 UDP- glucuronosyltransferase 1-9 Propofol 4-Hydroxypropofol 4-Quinol Sulfate 1-Quinol glucuronide Propofol 1-Quinol glucuronide 1-Quinol glucuronide 4-Hydroxypropofol 4-Quinol Sulfate Propofol glucuronide O2 NADPH H+ NADP H2O Uridine diphosphate glucuronic acid UDP H+ Uridine diphosphate glucuronic acid UDP H+ Heme Propofol Pathway Renal excretion Propofol is injected into the blood intravenously and travels directly to the target cells Hydroxypropofol has approximately a third of the hypnotic activity of Propofol 95-99% is bound to serum albumin or hemoglobin. The bound Propofol cannot enter the brain or muscles to activate or inhibit receptors Metabolites are excreted through the urine 4-Hydroxypropofol can be broken down further into more metabolites or excreted as is Hepatocyte Endoplasmic Reticulum Reaches target cells 15-30 seconds after injection. Is quickly metabolized as well.
Endoplasmic Reticulum SLC22A1 ABCC3 ABCC3 ABCC3 Unknown Unknown CYP2B6 UGT1A8 UGT1A9 Propofol 4- Hydroxypropofol 4-Quinol Sulfate 1-Quinol glucuronide Propofol 1-Quinol glucuronide 1-Quinol glucuronide 4- Hydroxypropofol 4-Quinol Sulfate Propofol glucuronide Oxygen NADPH Hydrogen Ion NADP Water Uridine diphosphate glucuronic acid UDP Hydrogen Ion Uridine diphosphate glucuronic acid UDP Hydrogen Ion Propofol Pathway Renal excretion
SLC22A1 ABCC3 ABCC3 ABCC3 CYP2B6 UGT1A8 UGT1A9 Propofo 4H 4-Qu Su 1-Qu gl Propofo 1-Qu gl 1-Qu gl 4H 4-Qu Su Pro glu O2 NADPH H+ NADP H2O UDPGlcA UDP H+ UDPGlcA UDP H+ Heme PW126624 Ren exc Propofol is injected into the blood intravenously and travels directly to the target cells Hydroxypropofol has approximately a third of the hypnotic activity of Propofol 95-99% is bound to serum albumin or hemoglobin. The bound Propofol cannot enter the brain or muscles to activate or inhibit receptors Metabolites are excreted through the urine 4-Hydroxypropofol can be broken down further into more metabolites or excreted as is Hepatocyte Endoplasmic Reticulum Reaches target cells 15-30 seconds after injection. Is quickly metabolized as well.