Quantitative metabolomics services for biomarker discovery and validation.
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Cytochrome P450 3A4 Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 3A5 P-glycoprotein P-glycoprotein P-glycoprotein ATP-dependent translocase ABCB1 Solute carrier family 15 member 1 Canalicular multispecific organic anion transporter 2 UDP- glucuronosyltransferase 2B7 Cytochrome P450 1A2 Fluconazole Fluconazole Fluconazole Fluconazole, Glucuronidated metabolite Fluconazole N-oxide Fluconazole Fluconazole Fluconazole N-oxide Fluconazole, Glucuronidated metabolite Uridine diphosphate glucuronic acid UDP H+ NADPH O2 H+ NADP H2O Heme Heme Heme Heme Heme Fluconazole Pathway Renal Excretion Fluconazole ingested through a pill Blood Vessel Intestinal Lumin Hepatocyte Intestinal Epithelial Cell Only 6.5% become Glucuronidated metabolite, Fluconazole 2% become Fluconazole N-oxide Fluconazole is sent to target cells unchanged Fluconazole inhibits 4 Cytochrome exzymes which causes hepatotoxicity in the liver when taken frequently or with previous liver dysfunction Endoplasmic Reticulum membrane 93.3% of the dose, 80% as unchanged Fluconazole, is excreted through the urine
Endoplasmic Reticulum CYP3A4 CYP2C9 CYP2C19 CYP3A5 ABCB1 ABCB1 ABCB1 ABCB1 SLC15A1 ABCC3 UGT2B7 CYP1A2 Fluconazole Fluconazole Fluconazole Fluconazole, Glucuronidated metabolite Fluconazole N-oxide Fluconazole Fluconazole Fluconazole N-oxide Fluconazole, Glucuronidated metabolite Uridine diphosphate glucuronic acid UDP Hydrogen Ion NADPH Oxygen Hydrogen Ion NADP Water Fluconazole Pathway Renal Excretion