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Lanosterol 14-alpha demethylase Methylsterol monooxygenase Delta(7)-sterol 5(6)-desaturase Ergosterol is essential in maintaining membrane integrity. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Ketoconazole 4,4-Dimethylcholesta- 8,14,24-trienol Ergosterol Lanosterol 14α-methyl-fecosterol 14α-methyl-3,6-diol O2 NADPH Formic acid H+ H2O NADP Heme Fe3+ Fe3+ 3-Keto-steroid reductase Steroid Biosynthesis Fungal yeast cell Bud of Fungus Cell Ketoconazole inhibits the production of ergosterol by inhibiting Lanosterol 14-alpha demethylase Ketoconazole is applied topically to the infected area Endoplasmic Reticulum Fungal Cell The accumulation of 14α-methyl-3,6-diol is toxic to the fungal cell and the cell membrane. It causes increased cell permeability and eventually cell death. The synthesis of 14α-methyl-fecosterol is triggered by the inhibition of Lanosterol 14-alpha demethylase.
Endoplasmic Reticulum ERG11 ERG25 ERG3 Ketoconazole 4,4- Dimethylcholesta- 8,14,24- trienol Ergosterol Lanosterol 14α-methyl- fecosterol 14α-methyl- 3,6-diol Oxygen NADPH Formic acid Hydrogen Ion Water NADP ERG27 Steroid Biosynthesis
ERG11 ERG25 ERG3 Ergosterol is essential in maintaining membrane integrity. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Nizoral FF-Mas Ergoste Lastrol 14-me-f 1-m-3-d O2 NADPH Formate H+ H2O NADP Heme Fe3+ Fe3+ ERG27 PW127409 Fungal yeast cell Bud of Fungus Cell Ketoconazole inhibits the production of ergosterol by inhibiting Lanosterol 14-alpha demethylase Ketoconazole is applied topically to the infected area Endoplasmic Reticulum Fungal Cell The accumulation of 14α-methyl-3,6-diol is toxic to the fungal cell and the cell membrane. It causes increased cell permeability and eventually cell death. The synthesis of 14α-methyl-fecosterol is triggered by the inhibition of Lanosterol 14-alpha demethylase.