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Naftifine 4,4-Dimethylcholesta- 8,14,24-trienol Ergosterol Naftifine Lanosterol O2 NADPH Formic acid H+ H2O NADP O2 NADPH H2O NADP Farnesyl pyrophosphate NADPH NADP PPi Squalene monooxygenase Lanosterol synthase Lanosterol 14-alpha demethylase Squalene synthase (S)-2,3-Epoxysqualene Squalene Steroid Biosynthesis FAD Heme Magnesium Fungal cell Naftifine inhibits Squalene monoxygenase, an enzyme essential in the synthesis of Ergosterol. Squalene monooxygenase is earlier in the pathway than the enzyme inhibited by other antifungal drugs The inhibition of Squalene monooxygenase prevents the synthesis of Ergosterol which is essential to fungal cell membrane integrity. Endoplasmic Reticulum Naftifine is commonly applied topically as a cream The inhibition of squalene monooxygenase causes a buildup of squalene which is toxic to the fungal cell. Diffusion
Endoplasmic Reticulum Naftifine 4,4- Dimethylcholesta- 8,14,24- trienol Ergosterol Naftifine Lanosterol Oxygen NADPH Formic acid Hydrogen Ion Water NADP Oxygen NADPH Water NADP Farnesyl pyrophosphate NADPH NADP Pyrophosphate ERG1 ERG7 ERG11 ERG9 (S)-2,3- Epoxysqualene Squalene Steroid Biosynthesis