Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Dihydrofolate reductase Dihydrofolate reductase Thymidylate synthase Bifunctional purine biosynthesis protein PURH Dihydrofolate reductase Proton-coupled folate transporter Tetrahydrofolic Acid Transporter Mitochondrial folate transporter/carrier Reduced Folate Carrier Mitochondrial folate transporter/carrier Gamma-glutamyl hydrolase Methotrexate Methotrexate Tetrahydrofolic acid Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Methotrexate Methotrexate Methotrexate Methotrexate Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl-[Glu](n) H2O L-Glutamic acid 10-Formyltetrahydrofolate AICAR Phosphoribosyl formamidocarboxamide Dihydrofolic acid NADPH NADP 5,10-Methylene-THF dUMP dTMP Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism Extracellular Space Cytosol Lysosome Mitochondria Methotrexate is a folic acid analogue that inhibits enzymes required to produce tetrahydrofolic acid (THF). DNA replication cannot occur due to lack of THF products. Methotrexate acts to inhibit thymidylate synthase, bifunctional purine biosynthesis protein (PURH) and dihydrofolate reductase which stops DNA replication and synthesis due to lack of substrates Cancer Cell Methotrexate is administered orally and diffuses into the bloodstream traveling to targets within the body
Lysosome Mitochondria DHFR DHFR TYMS ATIC DHFR SLC46A1 Unknown SLC25A32, MFT, MFTC SLC19A1 SLC25A32, MFT, MFTC GGH Methotrexate Methotrexate Tetrahydrofolic acid Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Methotrexate Methotrexate Methotrexate Methotrexate Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl- [Glu](n) Water L-Glutamic acid 10- Formyltetrahydrofolate AICAR Phosphoribosyl formamidocarboxamide Dihydrofolic acid NADPH NADP 5,10- Methylene-THF dUMP dTMP Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism