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Amiloride- sensitive sodium channel subunit alpha Amiloride- sensitive sodium channel subunit beta Amiloride- sensitive sodium channel subunit delta Amiloride- sensitive sodium channel subunit gamma Potassium channel subfamily K member 1 Urea transporter 2 Urea transporter 2 Chloride channel protein ClC-Ka Chloride channel protein ClC-Ka Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Na+ Na+ K+ Na+ K+ K+ Urea Urea Urea HCO3- HCO3- Cl- Cl- Cl- H2O H2O H2O H2O Cl- Cl- Amiloride Amiloride Amiloride Nephron Epithelial Cells Lumen Interstitium/Interstidial Fluid -50mV 0mV Amiloride enters the nephron in the kidney via the bloodstream Blocks the epithelium sodium channel (ENaC) by directly binding to it, it targets the alpha, beta, gamma and delta subunits. Sodium reabsorption is inhibited, leaving a higher concentration of water in the lumen Urea is reabsorbed in the collecting duct & K+ is spared as a result of Amiloride Amiloride is administered as an oral tablet.
SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 Unknown FXYD2 Sodium Sodium Potassium Sodium Potassium Potassium Urea Urea Urea Hydrogen carbonate Hydrogen carbonate Chloride ion Chloride ion Chloride ion Water Water Water Water Chloride ion Chloride ion Amiloride Amiloride Amiloride
SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 FXYD2 Na+ Na+ K+ Na+ K+ K+ Urea Urea Urea HCO3- HCO3- Cl- Cl- Cl- H2O H2O H2O H2O Cl- Cl- Amilori Amilori Amilori Nephron Epithelial Cells Lumen Interstitium/Interstidial Fluid -50mV 0mV Amiloride enters the nephron in the kidney via the bloodstream Blocks the epithelium sodium channel (ENaC) by directly binding to it, it targets the alpha, beta, gamma and delta subunits. Sodium reabsorption is inhibited, leaving a higher concentration of water in the lumen Urea is reabsorbed in the collecting duct & K+ is spared as a result of Amiloride Amiloride is administered as an oral tablet.
SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 FXYD2 Na+ Na+ K+ Na+ K+ K+ Urea Urea Urea HCO3 HCO3 Cl Cl Cl H2O H2O H2O H2O Cl Cl Amilori Amilori Amilori