Quantitative metabolomics services for biomarker discovery and validation.
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Thymidylate synthase Folylpolyglutamate synthase, mitochondrial Proton-coupled folate transporter Tetrahydrofolic Acid Transporter Mitochondrial folate transporter/carrier Reduced Folate Carrier Dihydrofolate reductase Dihydrofolate reductase Gamma-glutamyl hydrolase Monofunctional C1- tetrahydrofolate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Folylpolyglutamate synthase, mitochondrial Dihydrofolate reductase Raltitrexed Polyglutamate Tetrahydrofolic acid 5,10-Methylene-THF Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Raltitrexed Raltitrexed Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl-[Glu](n) H2O L-Glutamic acid ATP Formic acid ADP 10-Formyltetrahydrofolate Pi H+ 5,10-Methenyltetrahydrofolic acid H2O NADH NAD dUMP dTMP NADPH Tetrahydrofolic acid NADP ATP L-Glutamic acid ADP Phosphoric acid THF-L-glutamate Magnesium Calcium Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism Thymine Synthesis DNA synthesis and replication Dihydrofolic acid Glycine and Serine Metabolism Calcium Magnesium Extracellular Space Cytosol Lysosome Mitochondria 5,10-Methylene-THF, is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication Cancer Cell Raltitrexed is a folate analog, readily absorbed and transported into the body. Once metabolized into its primary metabolite it acts on thymidylate synthase and folylpolyglutamate synthase and inhibiting them halting processes needed for DNA replication and synthesis Raltitrexed is administered intravenously and travels to the target within the body
Lysosome Mitochondria TYMS FPGS SLC46A1 Unknown SLC25A32, MFT, MFTC SLC19A1 DHFR DHFR GGH MTHFD1L MTHFD2 MTHFD2 FPGS DHFR Raltitrexed Polyglutamate Tetrahydrofolic acid 5,10- Methylene-THF Folic acid Folic acid Tetrahydrofolic acid Tetrahydrofolic acid Raltitrexed Raltitrexed Dihydrofolic acid NADP NADPH NADPH NADP Tetrahydrofolyl- [Glu](n) Water L-Glutamic acid Adenosine triphosphate Formic acid Adenosine diphosphate 10- Formyltetrahydrofolate Phosphate Hydrogen Ion 5,10- Methenyltetrahydrofolic acid Water NADH NAD dUMP dTMP NADPH Tetrahydrofolic acid NADP Adenosine triphosphate L-Glutamic acid Adenosine diphosphate Phosphoric acid THF-L-glutamate Purine Metabolism Histidine Metabolism Methionine Metabolism Glycine and Serine Metabolism Thymine Synthesis DNA synthesis and replication Dihydrofolic acid Glycine and Serine Metabolism