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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 2B 5- hydroxytryptamine receptor 2C Guanine nucleotide- binding protein G(i) subunit alpha-1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Gγ Sodium- dependent serotonin transporter Synaptic vesicular amine transporter Multidrug resistance protein 1 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase 5- hydroxytryptamine receptor 1A Serotonin Serotonin Vilazodone Vilazodone Serotonin Serotonin Na+ Na+ Vilazodone Vilazodone L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Fe2+ Serotonin Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety Pyridoxal 5'-phosphate The serotonin receptors 2A,B,C are responsible for a variety of cognitive abilities such as learning, appetite, anxiety, memory, mood and sleep. Brain Other mechanisms of vilazodone include antagonism at serotonin 5-HT1a, 5-HT1c, and 5-HT21c receptor subtypes Vilazodone is absorbed from the gastrointestinal tract. Presynaptic axon terminal Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Synapse Vilazodone inhibits the serotonin reuptake transporter, causing serotonin accumulation in the synaptic cleft Increasing activation of serotonin receptors can increase stimulus for changes in downstream effects of these receptors affecting the mental state of the individual Serotonin is produced from the Raphei nucleus Blood vessel - Blood Brain Barrier At the presynaptic side, 5-HT activates 5-hydroxytryptamine (serotonin) receptor 1A (HTR1A), B (HTR1B), and D (HTR1D), which results in an attenuation of the 5-HT exocytosis
HTR2A HTR2B HTR2C GNAI1 GNB1 GNG2 SLC6A4 SLC18A2 ABCB1 TPH1 DDC HTR1A Serotonin Serotonin Vilazodone Vilazodone Serotonin Serotonin Sodium Sodium Vilazodone Vilazodone L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Serotonin Increase in vagus nerve stimulation and electrical impulses suppression of depression and anxiety