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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 1A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Chlorpromazine Chlorpromazine Ca+ Serotonin Chlorpromazine Chlorpromazine Chlorpromazine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Gi signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Chlorpromazine binds to 5HT1A and 5HT2A where it acts as a functional antagonist to reduce negative symptoms of schizophrenia ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Chlorpromazine also acts as an antagonist to D1 - D5, Alpha -1A, Alpha - 1B and H1, H4, 5HT2C receptors passive diffusion Passive diffusion Chlorpromazine is taken orally
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Chlorpromazine Chlorpromazine Calcium Serotonin Chlorpromazine Chlorpromazine Chlorpromazine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade Gi signaling cascade
HTR2A HTR1A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Cpz Cpz Ca+ 5-HT Cpz Cpz Cpz Trp BH4 O2 5-HTP <