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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Haloperidol Ca+ Dopamine Dopamine Haloperidol Haloperidol L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Haloperidol is a D2 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier presynaptic neuron arising from ventral tegmental area Postsynaptic neuron arising from nucleus accumbens Passive diffusion Haloperidol is taken orally and absorbed from the gastrointestinal tract when action potential arrives to the nerve terminal, calcium channels open causing influx of calcium ions which trigger the release of dopamine via exocytosis.
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Haloperidol Calcium Dopamine Dopamine Haloperidol Haloperidol L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Haldol Ca+ LDP LDP Haldol Haldol L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Haloperidol is a D2 receptor antagonist. Dopamine receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier presynaptic neuron arising from ventral tegmental area Postsynaptic neuron arising from nucleus accumbens Passive diffusion Haloperidol is taken orally and absorbed from the gastrointestinal tract when action potential arrives to the nerve terminal, calcium channels open causing influx of calcium ions which trigger the release of dopamine via exocytosis.
DRD2 CACNA1A CACNB1 CACNA2D2