SMPDB

Showing 81 - 100 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
P08195 View in UniProt HMDBP03090 View in HMDB	4F2 cell-surface antigen heavy chain Gene Name: SLC3A2 Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier	Metabolic	Amiloride Action Pathway Argininemia Argininosuccinic Aciduria Bendroflumethiazide Action Pathway Blue Diaper Syndrome Bumetanide Action Pathway Chlorothiazide Action Pathway Chlorthalidone Action Pathway Cyclothiazide Action Pathway Cystinuria Eplerenone Action Pathway (Old) Ethacrynic Acid Action Pathway Furosemide Action Pathway Glucose Transporter Defect (SGLT2) Glutaminolysis and Cancer Hartnup Disorder Hydrochlorothiazide Action Pathway Hydroflumethiazide Action Pathway Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Iminoglycinuria Indapamide Action Pathway Kidney Function- Proximal Convoluted Tubule Lysinuric Protein Intolerance Lysinuric Protein Intolerance (LPI) Maple Syrup Urine Disease Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA) Metabolism and Physiological Effects of Phenylacetic Acid Metabolism and Physiological Effects of Phenylacetylglutamine Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA) Methyclothiazide Action Pathway Metolazone Action Pathway (old) Phenylketonuria Polythiazide Action Pathway Quinethazone Action Pathway (old) Spironolactone Action Pathway Torsemide Action Pathway Triamterene Action Pathway Trichlormethiazide Action Pathway Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Tyrosinemia Type 3 (TYRO3) ( show more show less )
Q8TCD5 View in UniProt HMDBP00006 View in HMDB	5'(3')-deoxyribonucleotidase, cytosolic type Gene Name: NT5C Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.	Metabolic	Gemcitabine Action Pathway (old) Gemcitabine Metabolism Pathway (old) Lamivudine Metabolism Pathway
P21589 View in UniProt HMDBP00001 View in HMDB	5'-nucleotidase Gene Name: NT5E Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.	Metabolic	Didanosine Anti-viral Action Pathway Fludarabine Action Pathway Raltegravir Action Pathway
P17643 View in UniProt HMDBP02139 View in HMDB	5,6-dihydroxyindole-2-carboxylic acid oxidase Gene Name: TYRP1 Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized	Metabolic	Degradation of Superoxides
P13196 View in UniProt HMDBP00022 View in HMDB	5-aminolevulinate synthase, nonspecific, mitochondrial Gene Name: ALAS1	Metabolic	3-Phosphoglycerate Dehydrogenase Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency Acute Intermittent Porphyria Acute Intermittent Porphyria Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Dimethylglycine Dehydrogenase Deficiency Glycine and Serine Metabolism Hereditary Coproporphyria (HCP) Hereditary Coproporphyria (HCP) Hyperglycinemia, Non-Ketotic Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinemia Porphyria Variegata (PV) Porphyria Variegata (PV) Porphyrin Metabolism Sarcosinemia Sarcosinemia ( show more show less )
P49914 View in UniProt HMDBP01408 View in HMDB	5-formyltetrahydrofolate cyclo-ligase Gene Name: MTHFS Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.	Metabolic	Folate Malabsorption, Hereditary Folate Malabsorption, Hereditary Folate Metabolism Methotrexate Action Pathway Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
P08908 View in UniProt HMDBP02566 View in HMDB	5-hydroxytryptamine receptor 1A Gene Name: HTR1A This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity	Metabolic	3-Methylthiofentanyl Action Pathway Acepromazine - Serotonin Antagonist Action Pathway Alfentanil Action Pathway Alverine Serotonin Antagonist Action Pathway Alvimopan Action Pathway Anileridine Action Pathway Aripiprazole Serotonin Agonist Action Pathway Benzocaine Action Pathway Brexpiprazole Serotonin Action Action Pathway Bupivacaine Action Pathway Buprenorphine Action Pathway Carfentanil Action Pathway Chloroprocaine Action Pathway Chlorpromazine - Serotonin Antagonist Action Pathway Citalopram Action Pathway Citalopram Mechanism of Action Action Pathway New Cocaine Action Pathway Codeine Action Pathway Desipramine Action Pathway Dezocine Action Pathway Dibucaine Action Pathway Dihydromorphine Action Pathway Dimethylthiambutene Action Pathway Diphenoxylate Action Pathway Escitalopram Action Pathway Escitalopram Mechanism of Action Action Pathway New Ethylmorphine Action Pathway Fentanyl Action Pathway Flibanserin Serotonin Action Action Pathway Fluoxetine Action Pathway Fluvoxamine Mechanism of Action Action Pathway New Gi Serotonergic Smooth Muscle Relaxation Hydrocodone Action Pathway Hydromorphone Action Pathway Imipramine Ketobemidone Action Pathway Levallorphan Action Pathway Levobupivacaine Action Pathway Levomethadyl Acetate Action Action Pathway Levorphanol Action Pathway Lidocaine (Local Anaesthetic) Action Pathway Mepivacaine Action Pathway Methadone Action Pathway Methadyl Acetate Action Pathway Methysergide Mechanism of Action Action Pathway Morphine Action Pathway Nalbuphine Action Pathway Naloxone Action Pathway Naltrexone Action Pathway Neuron Function Nicotine Action Pathway Oxybuprocaine Action Pathway Oxycodone Action Pathway Oxymorphone Action Pathway Paroxetine Mechanism of Action Action Pathway New Pentazocine Action Pathway Prilocaine Action Pathway Procaine Action Pathway Proparacaine Action Pathway Propoxyphene Action Pathway Remifentanil Action Pathway Ropivacaine Action Pathway Sertraline Mechanism of Action Action Pathway New Sufentanil Action Pathway Thioridazine Dopamine Antagonist Action Pathway Tramadol Action Action Pathway Vilazodone mechanism of Action Action Pathway Vortioxetine Serotonin Action Action Pathway Ziprasidone Serotonin Action Action Pathway ( show more show less )
P28335 View in UniProt HMDBP02700 View in HMDB	5-hydroxytryptamine receptor 2C Gene Name: HTR2C This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system	Metabolic	Agomelatine Serotonin Antagonist Action Pathway Amine Oxidase Serotonin Amitriptyline Serotonin Antagonist Action Pathway Clomipramine Action Pathway (New) Desipramine Action Pathway (New) Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway Doxepin Norepinephrine Reuptake Inhibitor Action Pathway (New) Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway Fluoxetine - Serotonin reuptake Inhibition Action Pathway G-Protein Signaling Through Tubby Proteins Imipramine Action Pathway (New) Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway Levomilnacipran SNRI - Serotonin Reuptake Inhibition Action Pathway Milnacipran SNRI - Serotonin reuptake Inhibition Action Pathway Minaprine Serotonin receptor Antidepressant Action Pathway Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway Nortriptyline Action Pathway Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway Trimipramine Action Pathway Vilazodone mechanism of Action Action Pathway ( show more show less )
Q13639 View in UniProt HMDBP02219 View in HMDB	5-hydroxytryptamine receptor 4 Gene Name: HTR4 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase	Metabolic	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Gs Serotonergic Smooth Muscle Contraction Metoclopramide Serotonergic Smooth Muscle Contraction Prucalopride Action Pathway
P50406 View in UniProt HMDBP02713 View in HMDB	5-hydroxytryptamine receptor 6 Gene Name: HTR6 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs	Metabolic	Amoxapine SSRI Action Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
P34969 View in UniProt HMDBP02268 View in HMDB	5-hydroxytryptamine receptor 7 Gene Name: HTR7 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase	Metabolic	Amisulpride Serotonin Antagonist Action Pathway Amoxapine SSRI Action Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Lurasidone Serotonin Antagonist Action Pathway Vortioxetine Serotonin Action Action Pathway
O14841 View in UniProt HMDBP00855 View in HMDB	5-oxoprolinase Gene Name: OPLAH Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.	Metabolic	5-Oxoprolinase Deficiency 5-Oxoprolinase Deficiency 5-Oxoprolinuria 5-Oxoprolinuria gamma-Glutamyltransferase Deficiency gamma-Glutamyltransferase Deficiency gamma-Glutamyltranspeptidase Deficiency gamma-Glutamyltranspeptidase Deficiency Glutathione Metabolism Glutathione Synthetase Deficiency Glutathione Synthetase Deficiency ( show more show less )
P16118 View in UniProt HMDBP00799 View in HMDB	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Gene Name: PFKFB1 Synthesis and degradation of fructose 2,6-bisphosphate.	Metabolic	Fructose and Mannose Degradation Fructose Intolerance, Hereditary Fructose Intolerance, Hereditary Fructosuria Fructosuria
P17858 View in UniProt HMDBP00758 View in HMDB	6-phosphofructokinase, liver type Gene Name: PFKL Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.	Metabolic	Aerobic Glycolysis (Warburg Effect) Fructose and Mannose Degradation Fructose Intolerance, Hereditary Fructose Intolerance, Hereditary Fructosuria Fructosuria Glucose-6-phosphate Dehydrogenase Deficiency Glucose-6-phosphate Dehydrogenase Deficiency Pentose Phosphate Pathway Ribose-5-phosphate Isomerase Deficiency Ribose-5-phosphate Isomerase Deficiency Transaldolase Deficiency Transaldolase Deficiency ( show more show less )
P08237 View in UniProt HMDBP00762 View in HMDB	6-phosphofructokinase, muscle type Gene Name: PFKM Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.	Metabolic	Fanconi-Bickel Syndrome Fanconi-Bickel Syndrome Glycogenosis, Type VII. Tarui Disease Glycogenosis, Type VII. Tarui Disease Glycolysis
P52209 View in UniProt HMDBP01039 View in HMDB	6-phosphogluconate dehydrogenase, decarboxylating Gene Name: PGD Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).	Metabolic	Aerobic Glycolysis (Warburg Effect) Glucose-6-phosphate Dehydrogenase Deficiency Glucose-6-phosphate Dehydrogenase Deficiency Pentose Phosphate Pathway Ribose-5-phosphate Isomerase Deficiency Ribose-5-phosphate Isomerase Deficiency Transaldolase Deficiency Transaldolase Deficiency ( show more show less )
O95336 View in UniProt HMDBP00327 View in HMDB	6-phosphogluconolactonase Gene Name: PGLS Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	Metabolic	Aerobic Glycolysis (Warburg Effect) Glucose-6-phosphate Dehydrogenase Deficiency Glucose-6-phosphate Dehydrogenase Deficiency Pentose Phosphate Pathway Ribose-5-phosphate Isomerase Deficiency Ribose-5-phosphate Isomerase Deficiency Transaldolase Deficiency Transaldolase Deficiency ( show more show less )
Q03393 View in UniProt HMDBP00435 View in HMDB	6-pyruvoyl tetrahydrobiopterin synthase Gene Name: PTS Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.	Metabolic	DOPA-Responsive Dystonia DOPA-Responsive Dystonia Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to DHPR-Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Pterine Biosynthesis Segawa Syndrome Segawa Syndrome Sepiapterin Reductase Deficiency Sepiapterin Reductase Deficiency ( show more show less )
P05388 View in UniProt	60S acidic ribosomal protein P0 Gene Name: RPLP0 Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	Metabolic	Protein Synthesis: Alanine Protein Synthesis: Arginine Protein Synthesis: Asparagine Protein Synthesis: Aspartic Acid Protein Synthesis: Cysteine Protein Synthesis: Glutamic Acid Protein Synthesis: Glutamine Protein Synthesis: Glycine Protein Synthesis: Histidine Protein Synthesis: Isoleucine Protein Synthesis: Leucine Protein Synthesis: Lysine Protein Synthesis: Methionine Protein Synthesis: Phenylalanine Protein Synthesis: Proline Protein Synthesis: Serine Protein Synthesis: Threonine Protein Synthesis: Tryptophan Protein Synthesis: Tyrosine Protein Synthesis: Valine ( show more show less )
P05386 View in UniProt	60S acidic ribosomal protein P1 Gene Name: RPLP1 Plays an important role in the elongation step of protein synthesis.	Metabolic	Protein Synthesis: Alanine Protein Synthesis: Arginine Protein Synthesis: Asparagine Protein Synthesis: Aspartic Acid Protein Synthesis: Cysteine Protein Synthesis: Glutamic Acid Protein Synthesis: Glutamine Protein Synthesis: Glycine Protein Synthesis: Histidine Protein Synthesis: Isoleucine Protein Synthesis: Leucine Protein Synthesis: Lysine Protein Synthesis: Methionine Protein Synthesis: Phenylalanine Protein Synthesis: Proline Protein Synthesis: Serine Protein Synthesis: Threonine Protein Synthesis: Tryptophan Protein Synthesis: Tyrosine Protein Synthesis: Valine ( show more show less )

Showing 81 - 100 of 1576 proteins

Browsing Proteins

Protein ID

Protein Description

Pathway Class

Pathways

P08195

HMDBP03090

4F2 cell-surface antigen heavy chain

Q8TCD5

HMDBP00006

5'(3')-deoxyribonucleotidase, cytosolic type

P21589

HMDBP00001

5'-nucleotidase

P17643

HMDBP02139

5,6-dihydroxyindole-2-carboxylic acid oxidase

P13196

HMDBP00022

5-aminolevulinate synthase, nonspecific, mitochondrial

P49914

HMDBP01408

5-formyltetrahydrofolate cyclo-ligase

P08908

HMDBP02566

5-hydroxytryptamine receptor 1A

P28335

HMDBP02700

5-hydroxytryptamine receptor 2C

Q13639

HMDBP02219

5-hydroxytryptamine receptor 4

P50406

HMDBP02713

5-hydroxytryptamine receptor 6

P34969

HMDBP02268

5-hydroxytryptamine receptor 7

O14841

HMDBP00855

5-oxoprolinase

P16118

HMDBP00799

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

P17858

HMDBP00758

6-phosphofructokinase, liver type

P08237

HMDBP00762

6-phosphofructokinase, muscle type

P52209

HMDBP01039

6-phosphogluconate dehydrogenase, decarboxylating

O95336

HMDBP00327

6-phosphogluconolactonase

Q03393

HMDBP00435

6-pyruvoyl tetrahydrobiopterin synthase

P05388

60S acidic ribosomal protein P0

P05386

60S acidic ribosomal protein P1