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Showing 1421 - 1440 of 1576 proteins

Protein ID

Protein

Pathways

P37058

View in UniProt

HMDBP00846

View in HMDB

Testosterone 17-beta-dehydrogenase 3

Gene Name: HSD17B3

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.

P18074

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HMDBP08717

View in HMDB

TFIIH basal transcription factor complex helicase XPD subunit

Gene Name: ERCC2

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Q15750

View in UniProt

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene Name: TAB1

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Q9NYJ8

View in UniProt

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene Name: TAB2

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Q9NYJ8

View in UniProt

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene Name: TAB2

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Q8N5C8

View in UniProt

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Gene Name: TAB3

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Q9H3S4

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HMDBP00633

View in HMDB

Thiamin pyrophosphokinase 1

Gene Name: TPK1

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.

O60779

View in UniProt

HMDBP02627

View in HMDB

Thiamine transporter 1

Gene Name: SLC19A2

High-affinity transporter for the intake of thiamine.

Q9BU02

View in UniProt

HMDBP01574

View in HMDB

Thiamine-triphosphatase

Gene Name: THTPA

Hydrolase highly specific for thiamine triphosphate (ThTP).

P51580

View in UniProt

HMDBP00428

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Thiopurine S-methyltransferase

Gene Name: TPMT

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.

P10599

View in UniProt

Thioredoxin

Gene Name: TXN

P26639

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HMDBP00581

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Threonine--tRNA ligase, cytoplasmic

Gene Name: TARS

P00734

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Thrombin

P24557

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HMDBP01583

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Thromboxane-A synthase

Gene Name: TBXAS1

P04183

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HMDBP03814

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Thymidine kinase, cytosolic

Gene Name: TK1

P19971

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HMDBP03818

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Thymidine phosphorylase

Gene Name: TYMP

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

P04818

View in UniProt

HMDBP04363

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Thymidylate synthase

Gene Name: TYMS

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

P01266

View in UniProt

Thyroglobulin

Gene Name: TG

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

P07202

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HMDBP00276

View in HMDB

Thyroid peroxidase

Gene Name: TPO

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

P13726

View in UniProt

Tissue factor

Showing 1421 - 1440 of 1576 proteins