Browsing Proteins
Showing 1461 -
1480 of 1576 proteins
Protein ID |
Protein |
Pathways |
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P05412View in UniProtHMDBP02090View in HMDB |
Transcription factor AP-1Gene Name: JUN Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'
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Q01094View in UniProt |
Transcription factor E2F1Gene Name: E2F1
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).
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P43694View in UniProt |
Transcription factor GATA-4Gene Name: GATA4
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
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Q04206View in UniProt |
Transcription factor p65Gene Name: RELA
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
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P61586View in UniProtHMDBP01959View in HMDB |
Transforming protein RhoAGene Name: RHOA Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP
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Q9HBA0View in UniProtHMDBP02894View in HMDB |
Transient receptor potential cation channel subfamily V member 4Gene Name: TRPV4 Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8
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Q9NQA5View in UniProtHMDBP08085View in HMDB |
Transient receptor potential cation channel subfamily V member 5Gene Name: TRPV5 Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating
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P29401View in UniProtHMDBP00805View in HMDB |
TransketolaseGene Name: TKT Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
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DB00072View in DrugBank |
Trastuzumab |
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O43280View in UniProtHMDBP00374View in HMDB |
TrehalaseGene Name: TREH Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
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P53007View in UniProtHMDBP01599View in HMDB |
Tricarboxylate transport protein, mitochondrialGene Name: SLC25A1 Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway
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P40939View in UniProtHMDBP00389View in HMDB |
Trifunctional enzyme subunit alpha, mitochondrialGene Name: HADHA Bifunctional subunit.
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P55084View in UniProtHMDBP00048View in HMDB |
Trifunctional enzyme subunit beta, mitochondrialGene Name: HADHB |
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P22102View in UniProtHMDBP00330View in HMDB |
Trifunctional purine biosynthetic protein adenosine-3Gene Name: GART |
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Q9NVH6View in UniProtHMDBP03654View in HMDB |
Trimethyllysine dioxygenase, mitochondrialGene Name: TMLHE Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
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P60174View in UniProtHMDBP01584View in HMDB |
Triosephosphate isomeraseGene Name: TPI1 |
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P09493View in UniProtHMDBP08070View in HMDB |
Tropomyosin alpha-1 chainGene Name: TPM1 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
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P07951View in UniProtHMDBP08071View in HMDB |
Tropomyosin beta chainGene Name: TPM2 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
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P48775View in UniProtHMDBP05537View in HMDB |
Tryptophan 2,3-dioxygenaseGene Name: TDO2 Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
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P17752View in UniProtHMDBP00469View in HMDB |
Tryptophan 5-hydroxylase 1Gene Name: TPH1 |
Showing 1461 -
1480 of 1576 proteins