SMPDB

Showing 1521 - 1540 of 1576 proteins

Protein ID	Protein Description	Pathway Class	Pathways
Q14376 View in UniProt HMDBP00904 View in HMDB	UDP-glucose 4-epimerase Gene Name: GALE Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.	Metabolic	Galactose Metabolism Galactosemia Galactosemia Galactosemia II (GALK) Galactosemia II (GALK) Galactosemia III Galactosemia III Nucleotide Sugars Metabolism ( show more show less )
O60701 View in UniProt HMDBP00907 View in HMDB	UDP-glucose 6-dehydrogenase Gene Name: UGDH Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.	Metabolic	Galactosemia II (GALK) Galactosemia II (GALK) Galactosemia III Galactosemia III Glycogen Synthetase Deficiency Glycogen Synthetase Deficiency Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type VI. Hers Disease Glycogenosis, Type VI. Hers Disease Mucopolysaccharidosis VII. Sly Syndrome Mucopolysaccharidosis VII. Sly Syndrome Nucleotide Sugars Metabolism Starch and Sucrose Metabolism Sucrase-Isomaltase Deficiency Sucrase-Isomaltase Deficiency ( show more show less )
Q8NBZ7 View in UniProt HMDBP03150 View in HMDB	UDP-glucuronic acid decarboxylase 1 Gene Name: UXS1 Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.	Metabolic	Galactosemia II (GALK) Galactosemia II (GALK) Galactosemia III Galactosemia III Nucleotide Sugars Metabolism
P22309 View in UniProt HMDBP00483 View in HMDB	UDP-glucuronosyltransferase 1-1 Gene Name: UGT1A1 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.	Metabolic	Acetaminophen Metabolism Pathway Androstenedione Metabolism Estrone Metabolism Etoposide Action Pathway Etoposide Metabolism Pathway Etoricoxib Metabolism Pathway Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Irinotecan Action Pathway Irinotecan Metabolism Pathway Irinotecan Topoisomerase Inhibitor Action Pathway Methyldopa Metabolism Pathway Morphine Action Pathway Morphine Metabolism Pathway Phenytoin (Antiarrhythmic) Action Pathway Retinol Metabolism Rilpivirine Metabolism Pathway Sorafenib Metabolism Pathway (old) Vitamin A Deficiency Vitamin A Deficiency ( show more show less )
Q9HAW8 View in UniProt HMDBP00487 View in HMDB	UDP-glucuronosyltransferase 1-10 Gene Name: UGT1A10 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	Metabolic	Celecoxib metabolism Pathway Celecoxib metabolism Pathway Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Irinotecan Action Pathway Irinotecan Metabolism Pathway Nevirapine Metabolism Pathway Tamoxifen Action Pathway Tamoxifen Anti-Cancer Action Pathway Tamoxifen Metabolism Pathway ( show more show less )
P35503 View in UniProt HMDBP00486 View in HMDB	UDP-glucuronosyltransferase 1-3 Gene Name: UGT1A3 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	Metabolic	Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Morphine Action Pathway Morphine Metabolism Pathway Parecoxib Action Pathway Valproic Acid Metabolism Pathway Voriconazole Metabolism ( show more show less )
P22310 View in UniProt HMDBP00478 View in HMDB	UDP-glucuronosyltransferase 1-4 Gene Name: UGT1A4 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.	Metabolic	Nicotine Action Pathway Nicotine Metabolism Pathway Nicotine Metabolism Pathway Phenytoin (Antiarrhythmic) Action Pathway Rilpivirine Metabolism Pathway Tamoxifen Action Pathway Tamoxifen Metabolism Pathway ( show more show less )
P19224 View in UniProt HMDBP00489 View in HMDB	UDP-glucuronosyltransferase 1-6 Gene Name: UGT1A6 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.	Metabolic	Acetaminophen Metabolism Pathway Phenytoin (Antiarrhythmic) Action Pathway
Q9HAW7 View in UniProt HMDBP00494 View in HMDB	UDP-glucuronosyltransferase 1-7 Gene Name: UGT1A7 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	Metabolic	Metabolism and Physiological Effects of Para-cresyl glucuronide Mycophenolic Acid Metabolism Pathway (old)
Q9HAW9 View in UniProt HMDBP00485 View in HMDB	UDP-glucuronosyltransferase 1-8 Gene Name: UGT1A8 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	Metabolic	Morphine Action Pathway Morphine Metabolism Pathway Mycophenolic Acid Metabolism Pathway (old) Propofol Metabolism Tramadol Metabolism Pathway
O60656 View in UniProt HMDBP00484 View in HMDB	UDP-glucuronosyltransferase 1-9 Gene Name: UGT1A9 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.	Metabolic	Acetaminophen Metabolism Pathway Artemether Action Pathway (New) Artemether Metabolism Pathway Artesunate Action Pathway Buprenorphine Metabolism Fenofibrate Metabolism Pathway Haloperidol Metabolism Pathway Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Irinotecan Action Pathway Irinotecan Metabolism Pathway Levodopa Metabolism Pathway Mycophenolic Acid Metabolism Pathway (old) Nevirapine Metabolism Pathway Nicotine Action Pathway Nicotine Metabolism Pathway Phenytoin (Antiarrhythmic) Action Pathway Propofol Metabolism Sorafenib Metabolism Pathway (old) Venlafaxine Metabolism Pathway (New) ( show more show less )
O75310 View in UniProt HMDBP00491 View in HMDB	UDP-glucuronosyltransferase 2B11 Gene Name: UGT2B11 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	Metabolic	17-beta Hydroxysteroid Dehydrogenase III Deficiency 17-beta Hydroxysteroid Dehydrogenase III Deficiency Acute Intermittent Porphyria Acute Intermittent Porphyria Androgen and Estrogen Metabolism Aromatase Deficiency Aromatase Deficiency Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Glycogen Synthetase Deficiency Glycogen Synthetase Deficiency Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Glycogenosis, Type VI. Hers Disease Glycogenosis, Type VI. Hers Disease Hereditary Coproporphyria (HCP) Hereditary Coproporphyria (HCP) Irinotecan Metabolism Mucopolysaccharidosis VII. Sly Syndrome Mucopolysaccharidosis VII. Sly Syndrome Porphyria Variegata (PV) Porphyria Variegata (PV) Porphyrin Metabolism Starch and Sucrose Metabolism Sucrase-Isomaltase Deficiency Sucrase-Isomaltase Deficiency Warfarin Metabolism ( show more show less )
P54855 View in UniProt HMDBP00481 View in HMDB	UDP-glucuronosyltransferase 2B15 Gene Name: UGT2B15 UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.	Metabolic	Acetaminophen Metabolism Pathway Morphine Action Pathway Morphine Metabolism Pathway
O75795 View in UniProt HMDBP00488 View in HMDB	UDP-glucuronosyltransferase 2B17 Gene Name: UGT2B17 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).	Metabolic	17-beta Hydroxysteroid Dehydrogenase III Deficiency 17-beta Hydroxysteroid Dehydrogenase III Deficiency Androgen and Estrogen Metabolism Aromatase Deficiency Aromatase Deficiency Dextromethorphan metabolism ( show more show less )
P06133 View in UniProt HMDBP00458 View in HMDB	UDP-glucuronosyltransferase 2B4 Gene Name: UGT2B4 UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.	Metabolic	Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Morphine Action Pathway Morphine Metabolism Pathway
P16662 View in UniProt HMDBP00480 View in HMDB	UDP-glucuronosyltransferase 2B7 Gene Name: UGT2B7 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).	Metabolic	Acemetacin Action Pathway Artemether Action Pathway (New) Artemether Metabolism Pathway Artesunate Action Pathway Buprenorphine Metabolism Carbamazepine Metabolism Pathway Codeine Action Pathway Codeine Metabolism Pathway Codeine Opioid Action Pathway Dextromethorphan metabolism Etoricoxib Metabolism Fluconazole Metabolism Ibuprofen Action Pathway Ibuprofen Metabolism Pathway Morphine Action Pathway Morphine Metabolism Pathway Mycophenolic Acid Metabolism Pathway (old) Tramadol Metabolism Pathway Tramadol Metabolism Pathway (New) Zidovudine Metabolism ( show more show less )
Q16222 View in UniProt HMDBP01079 View in HMDB	UDP-N-acetylhexosamine pyrophosphorylase Gene Name: UAP1 Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.	Metabolic	Amino Sugar Metabolism Salla Disease/Infantile Sialic Acid Storage Disease Salla Disease/Infantile Sialic Acid Storage Disease Sialuria or French Type Sialuria Sialuria or French Type Sialuria Tay-Sachs Disease Tay-Sachs Disease ( show more show less )
P30085 View in UniProt HMDBP00003 View in HMDB	UMP-CMP kinase Gene Name: CMPK1 Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.	Metabolic	Capecitabine Action Pathway (New) Congenital Disorder of Glycosylation CDG-IId Fluorouracil Metabolism Fluorouracil Pyrimidine Analog Action Pathway Gemcitabine Action Pathway Gemcitabine Action Pathway (old) Gemcitabine Metabolism Pathway (old) GLUT-1 Deficiency Syndrome Lactose Synthesis Lamivudine Anti-viral Action Pathway Lamivudine Metabolism Pathway Zalcitabine Action Pathway (New) ( show more show less )
Q5EBM0 View in UniProt HMDBP07409 View in HMDB	UMP-CMP kinase 2, mitochondrial Gene Name: CMPK2 May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.	Metabolic	beta-Ureidopropionase Deficiency beta-Ureidopropionase Deficiency Dihydropyrimidinase Deficiency Dihydropyrimidinase Deficiency MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Pyrimidine Metabolism UMP Synthase Deficiency (Orotic Aciduria) UMP Synthase Deficiency (Orotic Aciduria) ( show more show less )
Unknown View in UniProt	Unknown	Metabolic	3-Methylglutaconic Aciduria Type III Amoxapine SSRI Action Pathway Bezafibrate Action Pathway (New) Brincidofovir Action Pathway Capecitabine Action Pathway (New) Carbimazole Action Pathway Chlorambucil Action Pathway Cidofovir Action Pathway Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway Docosanol Action Pathway Doxorubicin Topoisomerase Inhibitor Action Pathway Fenofibrate Action Pathway Fenofibrate Metabolism Pathway Fluorouracil Pyrimidine Analog Action Pathway Ganciclovir Action Pathway Gemfibrozil Action Pathway Levoleucovorin Action Pathway Metabolism and Physiological Effects of Dimethylglycine Metabolism and Physiological Effects of Orotic acid Metabolism and Physiological Effects of Oxalic acid Metabolism and Physiological Effects of Uric acid Metabolism and Physiological Effects of Uridine Metabolism and Physiological Effects of Xanthine Metabolism and Physiological Effects of Xanthosine Methotrexate Action Pathway (new) Mycophenolic Acid Action Pathway NF-kB Signaling Pathway Pafolacianine Action Pathway Pemetrexed Action Pathway Pralatrexate Action Pathway Quinethazone Action Pathway Raltitrexed Action Pathway Tamoxifen Anti-Cancer Action Pathway Valganciclovir Action Pathway Venlafaxine Metabolism Pathway (New) ( show more show less )

Showing 1521 - 1540 of 1576 proteins

Browsing Proteins

Protein ID

Protein Description

Pathway Class

Pathways

Q14376

HMDBP00904

UDP-glucose 4-epimerase

O60701

HMDBP00907

UDP-glucose 6-dehydrogenase

Q8NBZ7

HMDBP03150

UDP-glucuronic acid decarboxylase 1

P22309

HMDBP00483

UDP-glucuronosyltransferase 1-1

Q9HAW8

HMDBP00487

UDP-glucuronosyltransferase 1-10

P35503

HMDBP00486

UDP-glucuronosyltransferase 1-3

P22310

HMDBP00478

UDP-glucuronosyltransferase 1-4

P19224

HMDBP00489

UDP-glucuronosyltransferase 1-6

Q9HAW7

HMDBP00494

UDP-glucuronosyltransferase 1-7

Q9HAW9

HMDBP00485

UDP-glucuronosyltransferase 1-8

O60656

HMDBP00484

UDP-glucuronosyltransferase 1-9

O75310

HMDBP00491

UDP-glucuronosyltransferase 2B11

P54855

HMDBP00481

UDP-glucuronosyltransferase 2B15

O75795

HMDBP00488

UDP-glucuronosyltransferase 2B17

P06133

HMDBP00458

UDP-glucuronosyltransferase 2B4

P16662

HMDBP00480

UDP-glucuronosyltransferase 2B7

Q16222

HMDBP01079

UDP-N-acetylhexosamine pyrophosphorylase

P30085

HMDBP00003

UMP-CMP kinase

Q5EBM0

HMDBP07409

UMP-CMP kinase 2, mitochondrial

Unknown

Unknown