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Matched Description: molecule that belongs to a class of drugs called thiazides. Thiazides and thiazide-like drugs are diuretics … the nephron and therefore increase fluid loss which decreases extracellular fluid (ECF), plasma … volume, and ultimately blood pressure. In the case of quinethazone, it inhibits the sodium-chloride … long-term mechanism of action isn’t as well-characterized and it is thought that other processes … beyond regulating plasma and ECF volumes are involved as these two volumes return to baseline within 4-6 weeks of first use of thiazides.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: Furosemide (also named Lasix) is a medication that can be used for high blood pressure and fluid … build-up which caused by heart failure, liver scarring, or kidney disease. Furosemide can bind and … from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: that count for 5% of total amount. Solute carrier family 12 member 3 transports chloride and sodium … from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: administration (tablet, intravenous injections, eye drops, and intramuscular injections) that is … endocrine and rheumatic disorders. This drug is similar in structure to other corticosteroids like … hydrocortisone and prednisolone. As dexamethasone is a glucocorticoid, its mechanism of action is that of … suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences … transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2

Matched Compounds: PC(18:0/20:4(5Z,8Z,11Z,14Z))

Matched Compound Synonyms: Pc(18:0/20:4(5z,8z,11z,14z)) … Pc(18:0/20:4) … Pc(18:0/20:4omega6) … Phosphatidylcholine(18:0/20:4) … Phosphatidylcholine(18:0/20:4omega6)

Matched Description: Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is … to act on the distal convoluted tubule and the collecting duct of the nephron to make them more … membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of … mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the … smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.

Matched Compounds: Aldosterone

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase

Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one

Matched Description: Acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a … approved. It has analgesic, antipyretic, and anti-inflammatory effects. It targets the prostaglandin G … /H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The … inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to

Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … for oral administration. acemetacin mode of action as an anti-inflammatory and antirheumatic agent may … be due to inhibition of synthesis and release of prostaglandins. the usefulness of indometacin, the … . acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … , n-desacylation and part of them are also transformed by conjugation with glucuronic acid. the

Matched Compound Synonyms: Acetoxyl 2.5 and 5 … Dry and clear … Lucidol g 20 … Mixture of dibenzoyl peroxide and calcium sulfate … Mixture of dibenzoyl peroxide and calcium sulphate

Matched Description: Spironolactone is a steroidal, non specific, orally administered aldosterone antagonist used mainly … , hypertension, adrenal hyperplasia, edema, and nephrotic syndrome. It has also been shown to decrease … proteinuria. Spironolactone can be found under the brand names Aldactazide, Aldactone, and Carospir … sodium (Na+) and water (H2O) excretion and potassium (K+) retention. Once spironolactone is bound to the … MR, it blocks aldosterone from binding which inhibits aldosterone dependent sodium potassium

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone