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Matched Description: receptor inside the principal cells of the late distal tubule and collecting tubule. Aldosterone … Spironolactone is a potassium-sparing diuretic. It acts by competing with aldosterone for its … increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium … -potassium ATPases as well as luminal (apical) sodium and potassium channels. Sodium in the nephron … hyperosmotic and establishes an osmotic gradient, facilitating water reabsorption through aquaporin

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … [co2(oh)](-)

Matched Description: , and due to the enzyme not being entirely functional, it builds up in the cell, while aldosterone … less severe changes in aldosterone and 18-OHB concentrations. The CMO-II deficiency, and its … levels of aldosterone being lower due to this deficiency, excess sodium is excreted in the urine, and … aldosterone deficiency II among other names, is a genetic disorder that is autosomally linked. It is … formation of aldosterone from 18-hydroxycorticosterone (18-OHB), as well as converting progesterone to

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: -Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of … cortisol and sex steroids synthesis caused by a defect in the CYP17A1 gene which codes for Steroid 17 … -alpha-hydroxylase/17,20 lyase. These 2 enzymes catalyze pregnenolone and progesterone to their 17 … -hydroxy forms in steroidogenesis and mediate three key transformations in cortisol and sex steroid … synthesis. This disorder is characterized by a decrease in both cortisol and sex steroids and increase

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by a mutation … both progesterone and pregnenolone into 17-hydroxyprogesterone and 17a-hydroxypregnenolone … , deoxycorticosterone and 11-dehydrocorticosterone throughout the cell. 17-alpha hydroxylase … , as well as hypertension. Treatment with dexamethasone has been able to normalize blood pressure and

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: , and due to the enzyme not being entirely functional, it builds up in the cell, while aldosterone … less severe changes in aldosterone and 18-OHB concentrations. The CMO-II deficiency, and its … of aldosterone being lower due to this deficiency, excess sodium is excreted in the urine, and … aldosterone deficiency II among other names, is a genetic disorder that is autosomally linked. It is … formation of aldosterone from 18-hydroxycorticosterone (18-OHB), as well as converting progesterone to

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: inside the principal cells of the late distal tubule and collecting tubule. Aldosterone increases … Eplerenone is a potassium-sparing diuretic. It acts by competing with aldosterone for its receptor … sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium … -potassium ATPases as well as luminal (apical) sodium and potassium channels. Sodium in the nephron lumen … hyperosmotic and establishes an osmotic gradient, facilitating water reabsorption through aquaporin channels

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … [co2(oh)](-)

Matched Description: aldosterone deficiency among other names, is a genetic disorder that is autosomally linked and … , also called aldosterone synthase, which is used to catalyze the conversion of 18-hydroxycorticosterone … to aldosterone. This leads to a decrease in the amount of aldosterone present in the cells, which is … deficiency, aldosterone levels are so low that they are undetectable in plasma.

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the … conversion of cortexolone into cortisol which is useful for maintaining blood sugar levels and … endoplasmic reticulum (ER). Symptoms of the disorder include abnormality of hair growth rate and

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one

Matched Description: biosynthesis pathways, including those producing aldosterone and cortisol, and leads to a buildup of … cases of CAH. This deficiency affects cells in the adrenal cortex of the adrenal glands, and due to … -hydroxylase, and is caused by a complete lack of functional enzyme. This form is called the salt … -wasting form, as the lack of aldosterone produced leads to high levels of sodium excreted in the urine … if properly diagnosed, saline solution and hydrocortisone can restore normal blood levels and sodium

Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one