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Cytochrome P450
1A2
Cytochrome P450
1A2
Cytochrome P450
2E1
Arylamine N-
acetyltransferase
2
Cytochrome P450
1A2
Cytochrome P450
3A4
Cytochrome P450
2C8
Cytochrome P450
2C9
Cytochrome P450
2E1
Cytochrome P450
1A2
Cytochrome P450
1A2
Xanthine
dehydrogenase/oxidase
Xanthine
dehydrogenase/oxidase
Cytochrome P450
1A2
Cytochrome P450
3A4
Cytochrome P450
2C8
Cytochrome P450
2C9
Cytochrome P450
2E1
Cytochrome P450
1A2
Cytochrome P450
2A6
Xanthine
dehydrogenase/oxidase
5-Acetylamino-6-formylamino-
3-methyluracil
5-Acetylamino-6-amino-3-
methyluracil
Caffeine
NADH
O
2
Paraxanthine
NAD
H
2
O
Formaldehyde
NADH
O
2
Theobromine
NAD
H
2
O
Formaldehyde
Acetyl-CoA
CoA
NADH
O
2
Theophylline
NAD
H
2
O
Formaldehyde
NADH
O
2
7-Methylxanthine
NAD
H
2
O
Formaldehyde
NADH
O
2
1-Methylxanthine
NAD
H
2
O
Formaldehyde
H
2
O
O
2
1-Methyluric acid
H
2
O
2
O
2
H
2
O
7-Methyluric acid
H
2
O
2
O
2
H
2
O
1,3,7-Trimethyluric acid
H
2
O
2
O
2
H
2
O
1,7-Dimethyluric acid
H
2
O
2
H
2
O
O
2
3,7-Dimethyluric acid
H
2
O
2
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
FAD
2Fe-2S
Molybdopterin
FAD
2Fe-2S
Molybdopterin
Heme
FAD
2Fe-2S
Molybdopterin
Endoplasmic Reticulum
ER Membrane
ER Lumen
Lysosome
Lysosomal Lumen
Lysosomal Membrane
Liver Hepatic Cell
Endoplasmic Reticulum
Lysosome
CYP1A2
CYP1A2
CYP2E1
NAT2
CYP1A2
CYP3A4
CYP2C8
CYP2C9
CYP2E1
CYP1A2
CYP1A2
XDH
XDH
CYP1A2
CYP3A4
CYP2C8
CYP2C9
CYP2E1
CYP1A2
CYP2A6
XDH
5- Acetylamino-
6- formylamino-
3- methyluracil
5- Acetylamino-
6-amino-3-
methyluracil
Caffeine
NADH
Oxygen
Paraxanthine
NAD
Water
Formaldehyde
NADH
Oxygen
Theobromine
NAD
Water
Formaldehyde
Acetyl-CoA
Coenzyme A
NADH
Oxygen
Theophylline
NAD
Water
Formaldehyde
NADH
Oxygen
7-
Methylxanthine
NAD
Water
Formaldehyde
NADH
Oxygen
1-
Methylxanthine
NAD
Water
Formaldehyde
Water
Oxygen
1-Methyluric
acid
Hydrogen
peroxide
Oxygen
Water
7-Methyluric
acid
Hydrogen
peroxide
Oxygen
Water
1,3,7-
Trimethyluric
acid
Hydrogen
peroxide
Oxygen
Water
1,7-
Dimethyluric
acid
Hydrogen
peroxide
Water
Oxygen
3,7-
Dimethyluric
acid
Hydrogen
peroxide