C00438
KEGG Compound
C10H14N5O7P
3'-AMP
347.06308
Guanine deaminase
C00672
KEGG Compound
964-26-1
CAS
1.0
58580
ChemSpider
1.0
dUDP
4.0
6133
PubChem-compound
6131
PubChem-compound
6132
PubChem-compound
C19H21N7O6
Dihydrofolic acid
443.15533
2905-86-4
CAS
CHEBI:17594
ChEBI
CHEBI:17111
ChEBI
CHEBI:27389
ChEBI
13184-27-5
CAS
559142
ChemSpider
L-Dihydroorotic acid
Dihydroorotate dehydrogenase (quinone), mitochondrial
63-38-7
CAS
CHEBI:17568
ChEBI
C00459
KEGG Compound
C00458
KEGG Compound
5746
ChemSpider
HCO3
BioCyc
365-08-2
CAS
5742
ChemSpider
1.0
C00214
KEGG Compound
PW000162
PathWhiz
PW000160
PathWhiz
CHEBI:17562
ChEBI
1141
ChemSpider
CHEBI:16474
ChEBI
SMILES
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O
7540-64-9
CAS
439175
PubChem-compound
Thioredoxin
64968
PubChem-compound
C02642
KEGG Compound
C00460
KEGG Compound
P04183
UniProt
1.0
Thymidine 5'-triphosphate
SubPathwayInput
Dihydroorotate dehydrogenase (quinone), mitochondrial
2.0
HMDB0001096
HMDB
37610
ChemSpider
thioredoxin
64956
PubChem-compound
1.0
C00239
KEGG Compound
Ribonucleoside-diphosphate reductase subunit M2
CH4NO5P
Carbamoyl phosphate
140.98271
Quinone
C00472
KEGG Compound
1.0
Ribonucleoside-diphosphate reductase subunit M2
C00475
KEGG Compound
Cytidine deaminase
1.0
7664-38-2
CAS
C00009
KEGG Compound
C00008
KEGG Compound
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
C00005
KEGG Compound
NADPH
C00002
KEGG Compound
Inosine triphosphate pyrophosphatase
Nucleoside diphosphate kinase 6
1.0
1.0
93072
PubChem-compound
Q12882
UniProt
2.0
CHEBI:17361
ChEBI
C00011
KEGG Compound
C00015
KEGG Compound
C01346
KEGG Compound
C01103
KEGG Compound
C00014
KEGG Compound
C00013
KEGG Compound
1.0
58574
ChemSpider
1.0
56-65-5
CAS
388420
ChemSpider
CHEBI:26078
ChEBI
3.5.1.6
false
3.5.1.6
Ureidoisobutyric acid + Water → 3-Aminoisobutanoic acid + Ammonia + Carbon dioxide
LEFT_TO_RIGHT
3432-99-3
CAS
1.0
NADP
769
PubChem-compound
504-07-4
CAS
Dihydropyrimidinase
C01367
KEGG Compound
128553
ChemSpider
GTP:AMP phosphotransferase, mitochondrial
HMDB0001227
HMDB
SMILES
CC1=CNC(=O)NC1=O
98792
PubChem-compound
SMILES
OP(O)(=O)OP(O)(O)=O
56-85-9
CAS
C00288
KEGG Compound
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
DIHYDROFOLATE
BioCyc
7062
ChemSpider
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O
C9H14N2O12P2
Uridine 5'-diphosphate
404.0022
1.0
UTP
BioCyc
5902
ChemSpider
5901
ChemSpider
5903
ChemSpider
C00055
KEGG Compound
C00295
KEGG Compound
C00299
KEGG Compound
1.0
HMDB0001245
HMDB
HMDB0001489
HMDB
SMILES
OC(=O)C1=CC(=O)NC(=O)N1
C00063
KEGG Compound
145729
PubChem-compound
Q9UIJ7
UniProt
5,10-Methylene-THF
HMDB0001000
HMDB
DUDP
BioCyc
C10H16N5O13P3
Adenosine triphosphate
506.99576
Phosphoric acid
CHEBI:18261
ChEBI
C00064
KEGG Compound
4033-27-6
CAS
Uridine monophosphate synthetase isoform A
65-47-4
CAS
Ureidopropionic acid
58-96-8
CAS
C4H9NO2
3-Aminoisobutanoic acid
103.06333
C5H8N2O5
Ureidosuccinic acid
176.04332
41211
PubChem-compound
Uridine-cytidine kinase-like 1
962
PubChem-compound
1.0
967
PubChem-compound
58-98-0
CAS
CHEBI:18077
ChEBI
C00075
KEGG Compound
CO2
Carbon dioxide
43.98983
CHEBI:18075
ChEBI
13712
PubChem-compound
13711
PubChem-compound
951-77-9
CAS
HMDB0002111
HMDB
Q7LG56
UniProt
DNA reaction
SubPathway
6175
PubChem-compound
14265-44-2
CAS
6176
PubChem-compound
Beta-ureidopropionase
Dihydropyrimidinase
13945
PubChem-compound
THYMINE
BioCyc
Q9NWZ5
UniProt
UMP-CMP kinase 2, mitochondrial
Phosphoribosyl pyrophosphate
SubPathwayInput
HMDB0001274
HMDB
1103
ChemSpider
644102
PubChem-compound
84456
ChemSpider
5941
ChemSpider
C4H4N2O2
Uracil
112.027275
C9H12N2O6
Uridine
244.06953
C00099
KEGG Compound
5940
ChemSpider
Carbamoyl phosphate
SubPathwayOutput
SMILES
OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O
CHEBI:18050
ChEBI
SMILES
O[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O
RNA reaction
SubPathway
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
DEOXYCYTIDINE
BioCyc
UMP-CMP kinase 2, mitochondrial
UMP
BioCyc
Uridine-cytidine kinase-like 1
629
ChemSpider
Ribonucleoside-diphosphate reductase subunit M2 B
1.0
CH2O3
Hydrogen carbonate
62.000393
HMDB0002142
HMDB
HMDB0001056
HMDB
17215925
ChemSpider
1032-65-1
CAS
1.0
CTP synthase 1
1135
PubChem-compound
SMILES
O=C1NC=CC(=O)N1
Deoxycytidylate deaminase
1.0
C5H10N2O3
Ureidoisobutyric acid
146.06914
ReactionCatalysis1209
ACTIVATION
ReactionCatalysis1208
ACTIVATION
H3N
Ammonia
17.026548
HMDB0000538
HMDB
5961
PubChem-compound
111
PubChem-compound
Q02127
UniProt
P27708
UniProt
ReactionCatalysis1214
ACTIVATION
ReactionCatalysis1213
ACTIVATION
ReactionCatalysis1215
ACTIVATION
HMDB0000300
HMDB
C05100
KEGG Compound
ReactionCatalysis1218
ACTIVATION
ReactionCatalysis1217
ACTIVATION
SMILES
OC(O)=O
ReactionCatalysis1219
ACTIVATION
ReactionCatalysis1210
ACTIVATION
ReactionCatalysis1212
ACTIVATION
ReactionCatalysis1211
ACTIVATION
C3H7NO2
β-Alanine
89.047676
C9H13N3O4
Deoxycytidine
227.0906
C9H12N2O5
Deoxyuridine
228.07462
696-04-8
CAS
4.0
Uridine 5'-monophosphate
ReactionCatalysis1225
ACTIVATION
ReactionCatalysis1224
ACTIVATION
ReactionCatalysis1227
ACTIVATION
ReactionCatalysis1226
ACTIVATION
ReactionCatalysis1229
ACTIVATION
274
ChemSpider
Nucleoside diphosphate kinase 6
272
ChemSpider
4208-67-7
CAS
DUMP
BioCyc
ReactionCatalysis1221
ACTIVATION
ReactionCatalysis1220
ACTIVATION
1.0
141140
ChemSpider
C4H8N2O3
Ureidopropionic acid
132.0535
1.0
CHEBI:15713
ChEBI
Pyrophosphate
H3O4P
Phosphate
97.9769
HMDB0001409
HMDB
DI-H-URACIL
BioCyc
4650
PubChem-compound
Cytidine monophosphate
ReactionCatalysis1236
ACTIVATION
ReactionCatalysis1235
ACTIVATION
ReactionCatalysis1238
ACTIVATION
ReactionCatalysis1237
ACTIVATION
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
ReactionCatalysis1239
ACTIVATION
ReactionCatalysis1230
ACTIVATION
C00906
KEGG Compound
ReactionCatalysis1232
ACTIVATION
Q14117
UniProt
ReactionCatalysis1231
ACTIVATION
ReactionCatalysis1234
ACTIVATION
ReactionCatalysis1233
ACTIVATION
141172
ChemSpider
NADPH
BioCyc
1.0
SMILES
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1
Carbon dioxide
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O
1.0
Dihydrothymine
217
ChemSpider
Q9UBR1
UniProt
SMILES
OP(O)(O)=O
CHEBI:28846
ChEBI
CYTIDINE
BioCyc
SMP0000046
SMPDB
dUMP
1.0
1.0
CAD protein
HMDB0001429
HMDB
SMILES
NC(=O)NCCC(O)=O
3-UREIDO-PROPIONATE
BioCyc
C05145
KEGG Compound
3-AMINO-ISOBUTYRATE
BioCyc
C20H23N7O6
5,10-Methylene-THF
457.171
GTP:AMP phosphotransferase, mitochondrial
thioredoxin disulfide
SMP0000059
SMPDB
1.0
Dihydrouracil
SMP0000055
SMPDB
1.0
SMILES
O=C=O
HMDB0000595
HMDB
234
ChemSpider
HMDB0001202
HMDB
P04818
UniProt
C5H11O8P
Ribose 1-phosphate
230.01915
5957
PubChem-compound
C9H16N3O14P3
Cytidine triphosphate
482.9845
C5H8N2O2
Dihydrothymine
128.05858
C4H6N2O2
Dihydrouracil
114.04293
C00705
KEGG Compound
CARBAMYUL-L-ASPARTATE
BioCyc
C9H13N3O5
Cytidine
243.08553
SMP0000072
SMPDB
C9H14N3O8P
Cytidine monophosphate
323.05185
OROTIDINE-5-PHOSPHATE
BioCyc
P33316
UniProt
Cytosolic purine 5'-nucleotidase
CHEBI:17748
ChEBI
Q9BY32
UniProt
UDP
BioCyc
P49902
UniProt
14000-31-8
CAS
DIHYDRO-THYMINE
BioCyc
93556
PubChem-compound
5675
ChemSpider
B-ALANINE
BioCyc
Deoxyuridine
65063
PubChem-compound
Thymidine kinase, cytosolic
Thymidine phosphorylase
65070
PubChem-compound
SMILES
NC(=O)OP(O)(O)=O
1.0
Soluble calcium-activated nucleotidase 1
Uridine triphosphate
SubPathwayInput
Uridine
SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1
Dihydropyrimidinase
CDP
SubPathwayInput
C9H15N3O11P2
CDP
403.0182
Water
9700
PubChem-compound
SMILES
NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
2.0
65091
PubChem-compound
DUTP
BioCyc
1.0
β-Alanine
SubPathwayInput
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
SMP0000032
SMPDB
CHEBI:28850
ChEBI
SMP0000031
SMPDB
9606
TAXONOMY
1.0
CHEBI:17544
ChEBI
dCTP
SubPathwayInput
1.0
1174
PubChem-compound
CHEBI:16450
ChEBI
Deoxyuridine triphosphate
CHEBI:16695
ChEBI
ReactionCatalysis1246
ACTIVATION
ReactionCatalysis1249
ACTIVATION
ReactionCatalysis1248
ACTIVATION
Ureidoisobutyric acid
1.0
ReactionCatalysis1241
ACTIVATION
ReactionCatalysis1240
ACTIVATION
ReactionCatalysis1243
ACTIVATION
ReactionCatalysis1242
ACTIVATION
ReactionCatalysis1244
ACTIVATION
CHEBI:15377
ChEBI
C00526
KEGG Compound
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
SMILES
NC(=O)N[C@@H](CC(O)=O)C(O)=O
SMILES
CC(CN)C(O)=O
ReactionCatalysis1250
ACTIVATION
3-UREIDO-ISOBUTYRATE
BioCyc
ReactionCatalysis1252
ACTIVATION
ReactionCatalysis1251
ACTIVATION
ReactionCatalysis1254
ACTIVATION
PW000001
PathWhiz
L-Glutamine
SubPathwayInput
PW000003
PathWhiz
89228
ChemSpider
388373
ChemSpider
PRPP
BioCyc
ReactionCatalysis1268
ACTIVATION
HMDB0000998
HMDB
Orotic acid
ReactionCatalysis1261
ACTIVATION
ReactionCatalysis1263
ACTIVATION
ReactionCatalysis1262
ACTIVATION
ReactionCatalysis1265
ACTIVATION
P31350
UniProt
ReactionCatalysis1267
ACTIVATION
Ribose 1-phosphate
ReactionCatalysis1266
ACTIVATION
5789
PubChem-compound
106-51-4
CAS
DEOXYURIDINE
BioCyc
ReactionCatalysis1271
ACTIVATION
ReactionCatalysis1274
ACTIVATION
6022
PubChem-compound
365-07-1
CAS
937
ChemSpider
6029
PubChem-compound
388355
ChemSpider
CHEBI:16134
ChEBI
2.7.4.6
false
2.7.4.6
Adenosine diphosphate + Uridine triphosphate ↔ Adenosine triphosphate + Uridine 5'-diphosphate
REVERSIBLE
3.6.1.6
false
3.6.1.6
Uridine 5'-diphosphate + Water → Phosphate + Uridine 5'-monophosphate
LEFT_TO_RIGHT
Reaction1494
false
Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate
LEFT_TO_RIGHT
Reaction1491
false
Orotic acid + Phosphoribosyl pyrophosphate ↔ Orotidylic acid
REVERSIBLE
Reaction1492
false
Orotidylic acid → Uridine 5'-monophosphate
LEFT_TO_RIGHT
1.3.5.2
false
1.3.5.2
L-Dihydroorotic acid + Quinone → Orotic acid + quinol
LEFT_TO_RIGHT
HMDB0002031
HMDB
HMDB0000095
HMDB
6.3.4.2
false
6.3.4.2
Adenosine triphosphate + Uridine triphosphate → Adenosine diphosphate + Cytidine triphosphate + Phosphate + dCTP
LEFT_TO_RIGHT
2.7.4.10
false
2.7.4.10
Adenosine diphosphate + Uridine 5'-diphosphate → 3'-AMP + Uridine triphosphate
LEFT_TO_RIGHT
HMDB0003364
HMDB
3.6.1.19
false
3.6.1.19
Uridine triphosphate + Water → Pyrophosphate + Uridine 5'-monophosphate
LEFT_TO_RIGHT
PW000055
PathWhiz
CHEBI:17239
ChEBI
HMDB0001191
HMDB
C10H15N2O8P
5-Thymidylic acid
322.0566
ATP
BioCyc
PW000051
PathWhiz
1.0
3-Aminoisobutanoic acid
SubPathwayOutput
Reaction1488
false
Carbamoyl phosphate → Ureidosuccinic acid
LEFT_TO_RIGHT
Reaction1489
false
Ureidosuccinic acid → L-Dihydroorotic acid
LEFT_TO_RIGHT
Reaction1487
false
2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphate
LEFT_TO_RIGHT
Deoxycytidylate deaminase
C00337
KEGG Compound
C9H15N2O14P3
Deoxyuridine triphosphate
467.9736
58481
ChemSpider
Thymidylate synthase
C00106
KEGG Compound
C00105
KEGG Compound
6030
PubChem-compound
6031
PubChem-compound
800-73-7
CAS
METHYLENE-THF
BioCyc
58493
ChemSpider
C9H14N3O7P
dCMP
307.05695
942
ChemSpider
CHEBI:15033
ChEBI
Uridine 5'-diphosphate
SubPathwayInput
PPI
BioCyc
439287
PubChem-compound
63-37-6
CAS
C00119
KEGG Compound
THYMIDINE
BioCyc
160617
PubChem-compound
SMILES
O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
C10H16N2O11P2
dTDP
402.02292
1.0
1.0
C5H10N2O3
L-Glutamine
146.06914
Cytosol
CHEBI:17025
ChEBI
1.0
C00112
KEGG Compound
Deoxyribose 1-phosphate
dTDP
13118
ChemSpider
13117
ChemSpider
1.0
Ribonucleoside-diphosphate reductase large subunit
O75414
UniProt
SubPathwayInteraction345
SubPathway345Reaction
SubPathwayReaction
O95045
UniProt
SubPathwayInteraction343
SubPathwayReaction
SubPathway343Reaction
SMILES
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1
SubPathwayInteraction344
SubPathway344Reaction
SubPathwayReaction
C00364
KEGG Compound
CTP
BioCyc
C00363
KEGG Compound
CHEBI:18361
ChEBI
DEOXY-RIBOSE-1P
BioCyc
CHEBI:18367
ChEBI
1032
ChemSpider
C00365
KEGG Compound
388320
ChemSpider
Dihydropyrimidine dehydrogenase [NADP(+)]
P19971
UniProt
Ureidosuccinic acid
65-86-1
CAS
SubPathwayInteraction340
SubPathwayReaction
SubPathway340Reaction
C9H15N3O10P2
dCDP
387.02325
7339
PubChem-compound
NAD(P)
BioCyc
Cytosolic purine 5'-nucleotidase
C00143
KEGG Compound
1.0
CHEBI:17013
ChEBI
5988-19-2
CAS
13343
ChemSpider
2.0
TTP
BioCyc
462-88-4
CAS
DCDP
BioCyc
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
HMDB0000012
HMDB
Inosine triphosphate pyrophosphatase
SMILES
O=C1CCNC(=O)N1
HMDB0000014
HMDB
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O
SMILES
CC1CNC(=O)NC1=O
649
PubChem-compound
C9H14N2O11P2
dUDP
388.0073
HMDB0000250
HMDB
C9H16N3O13P3
dCTP
466.9896
HMDB0001342
HMDB
HMDB0001341
HMDB
Q9Y2T3
UniProt
5-Thymidylic acid
1.0
C00169
KEGG Compound
58-97-9
CAS
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
HMDB0000026
HMDB
dCDP
65-46-3
CAS
HMDB0001351
HMDB
HMDB0000262
HMDB
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
SubPathwayInteraction335
SubPathwayReaction
SubPathway335Reaction
DI-H-OROTATE
BioCyc
URACIL
BioCyc
C5H6N2O4
L-Dihydroorotic acid
158.03276
7732-18-5
CAS
C00178
KEGG Compound
SMILES
CC(CNC(N)=O)C(O)=O
C6H4O2
Quinone
108.021126
AMMONIA
BioCyc
SMILES
N
590-55-6
CAS
HMDB0000273
HMDB
HMDB0003540
HMDB
Thioredoxin
SubPathwayInteraction328
SubPathwayReaction
SubPathway328Reaction
SubPathwayInteraction329
SubPathwayReaction
SubPathway329Reaction
Thioredoxin disulfide
HMDB0000288
HMDB
132961
ChemSpider
1.0
Dihydropyrimidine dehydrogenase [NADP(+)]
HMDB0000280
HMDB
SMILES
NCCC(O)=O
HMDB0000285
HMDB
OROTATE
BioCyc
5800
ChemSpider
979
ChemSpider
CMP
BioCyc
HMDB0000056
HMDB
CAD protein
H3O4P
Phosphoric acid
97.9769
CHEBI:18191
ChEBI
144-90-1
CAS
Glutamate Metabolism
SubPathway
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
HMDB0000051
HMDB
HMDB0000295
HMDB
5807
ChemSpider
5809
ChemSpider
5808
ChemSpider
HMDB0000296
HMDB
CHEBI:15918
ChEBI
TMP
BioCyc
dCMP
Uracil
58-64-0
CAS
1.0
951-78-0
CAS
CTP synthase 1
HMDB0000079
HMDB
1.0
22833512
PubChem-compound
H2O
Water
18.010565
HMDB0003349
HMDB
HMDB0000076
HMDB
1.0
1.0
749
ChemSpider
71-52-3
CAS
Guanine deaminase
CAD protein
HMDB0000089
HMDB
SMILES
[H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O
HMDB0000082
HMDB
CHEBI:15901
ChEBI
2149-82-8
CAS
CHEBI:15842
ChEBI
66-22-8
CAS
1.0
RIBOSE-1P
BioCyc
Beta-ureidopropionase
Valine, Leucine, and Isoleucine Degradation
SubPathway
Dihydrofolic acid
Pentose Phosphate Pathway
SubPathway
SMILES
O
1.0
C5H4N2O4
Orotic acid
156.0171
Dihydropyrimidine dehydrogenase [NADP(+)]
1.0
1.0
239
PubChem-compound
1004
PubChem-compound
Thymidylate synthase
1.0
Orotidylic acid
ADP
BioCyc
Inosine triphosphate pyrophosphatase
Pyrimidine Metabolism
53-59-8
CAS
Guanine deaminase
Thymidine kinase, cytosolic
SMILES
O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
GO:0005829
GENE ONTOLOGY
Alanine Metabolism
SubPathway
SMILES
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1
1.0
Urea Cycle
SubPathway
Cytidine
Ammonia
164628
PubChem-compound
P17812
UniProt
Soluble calcium-activated nucleotidase 1
HMDB0001533
HMDB
C21H30N7O17P3
NADPH
745.0911
C10H13N2O11P
Orotidylic acid
368.0257
C21H28N7O17P3
NADP
743.07544
1.0
2056-98-6
CAS
144320
ChemSpider
CHEBI:17821
ChEBI
C9H15N2O15P3
Uridine triphosphate
483.96854
C5H11O7P
Deoxyribose 1-phosphate
214.02425
C5H13O14P3
Phosphoribosyl pyrophosphate
389.9518
HMDB0001546
HMDB
HMDB0000217
HMDB
1.0
124-38-9
CAS
Thioredoxin disulfide
6.0
C9H13N2O9P
Uridine 5'-monophosphate
324.03586
CHEBI:16742
ChEBI
Cytidine deaminase
Uridine monophosphate synthetase isoform A
9319
ChemSpider
50-89-5
CAS
HMDB0000218
HMDB
URIDINE
BioCyc
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
HMDB0000226
HMDB
Q8WVQ1
UniProt
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
GLN
BioCyc
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C(=O)NC(=O)C=C1C(O)=O
CDP
BioCyc
7664-41-7
CAS
107-95-9
CAS
84022
ChemSpider
Hydrogen carbonate
53-57-6
CAS
3.5.4.5
false
3.5.4.5
Deoxycytidine + Water → Ammonia + Deoxyuridine
LEFT_TO_RIGHT
2.4.2.4
false
2.4.2.4
Deoxyuridine + Phosphate → Deoxyribose 1-phosphate + Uracil
LEFT_TO_RIGHT
3.1.3.5
false
3.1.3.5
Water + dCMP → Deoxycytidine + Phosphate
LEFT_TO_RIGHT
2.7.1.48
false
2.7.1.48
Adenosine triphosphate + Deoxycytidine → Adenosine diphosphate + dCMP
LEFT_TO_RIGHT
222
PubChem-compound
TDP
BioCyc
SMILES
OP(O)(O)=O
H4O7P2
Pyrophosphate
177.94322
2.7.4.6
false
2.7.4.6
Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP
LEFT_TO_RIGHT
C5H6N2O2
Thymine
126.04293
Thymine
CHEBI:16704
ChEBI
Reaction1515
false
Adenosine triphosphate + dCMP → Adenosine diphosphate + dCDP
LEFT_TO_RIGHT
3.5.1.6
false
3.5.1.6
Ureidopropionic acid + Water → Ammonia + Carbon dioxide + β-Alanine
LEFT_TO_RIGHT
CHEBI:15859
ChEBI
1.17.4.1
false
1.17.4.1
CDP + Water + thioredoxin disulfide → dCDP + thioredoxin
LEFT_TO_RIGHT
1.3.1.2
false
1.3.1.2
NADP + Uracil → Dihydrouracil + NADPH
LEFT_TO_RIGHT
3.5.2.2
false
3.5.2.2
Dihydrouracil + Water → Ureidopropionic acid
LEFT_TO_RIGHT
2.4.2.3
false
2.4.2.3
Phosphate + Uridine → Ribose 1-phosphate + Uracil
LEFT_TO_RIGHT
3.5.4.3
false
3.5.4.3
Cytidine + Water → Ammonia + Uridine
LEFT_TO_RIGHT
DCMP
BioCyc
3.1.3.5
false
3.1.3.5
Uridine 5'-monophosphate + Water → Phosphate + Uridine
LEFT_TO_RIGHT
CHEBI:15633
ChEBI
Reaction1505
false
Adenosine diphosphate + CDP ↔ Adenosine triphosphate + Cytidine monophosphate
REVERSIBLE
CHEBI:15636
ChEBI
1.0
109
ChemSpider
3.1.3.5
false
3.1.3.5
Cytidine monophosphate + Water → Cytidine + Phosphoric acid
LEFT_TO_RIGHT
Uridine phosphorylase 2
Adenosine triphosphate
CHEBI:28931
ChEBI
C10H15N5O10P2
Adenosine diphosphate
427.02942
C10H17N2O14P3
Thymidine 5'-triphosphate
481.98926
2.7.4.6
false
2.7.4.6
Adenosine diphosphate + Cytidine triphosphate ↔ Adenosine triphosphate + CDP
REVERSIBLE
CHEBI:16958
ChEBI
3.6.1.6
false
3.6.1.6
CDP + Water → Cytidine monophosphate + Phosphate
LEFT_TO_RIGHT
3.6.1.6
false
3.6.1.6
Cytidine triphosphate + Water → CDP + Phosphate
LEFT_TO_RIGHT
C10H14N2O5
Thymidine
242.09027
1.0
CHEBI:17622
ChEBI
CHEBI:17625
ChEBI
CPD-8587
BioCyc
SMILES
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1
C9H13N2O8P
dUMP
308.04095
150855
PubChem-compound
2.1.1.45
false
2.1.1.45
Adenosine triphosphate + dUMP ↔ Adenosine diphosphate + dUDP
REVERSIBLE
1.17.4.1
false
1.17.4.1
Thioredoxin disulfide + Uridine 5'-diphosphate + Water → Thioredoxin + dUDP
LEFT_TO_RIGHT
3.6.1.23
false
3.6.1.23
Deoxyuridine triphosphate + Water → Phosphate + dUMP
LEFT_TO_RIGHT
2.7.4.6
false
2.7.4.6
Adenosine diphosphate + Deoxyuridine triphosphate → Adenosine triphosphate + dUDP
LEFT_TO_RIGHT
3.5.2.2
false
3.5.2.2
Dihydrothymine + Water → Ureidoisobutyric acid
LEFT_TO_RIGHT
DCTP
BioCyc
3'-AMP
2.4.2.4
false
2.4.2.4
Phosphate + Thymidine → Deoxyribose 1-phosphate + Thymine
LEFT_TO_RIGHT
1.3.1.2
false
1.3.1.2
NADP + Thymine → Dihydrothymine + NADPH
LEFT_TO_RIGHT
CHEBI:16300
ChEBI
CHEBI:15698
ChEBI
CARBAMOYL-P
BioCyc
2.7.1.21
false
2.7.1.21
Adenosine triphosphate + Thymidine → 5-Thymidylic acid + Adenosine diphosphate
LEFT_TO_RIGHT
3.6.1.6
false
3.6.1.6
Thymidine 5'-triphosphate + Water → Phosphate + dTDP
LEFT_TO_RIGHT
3.1.3.5
false
3.1.3.5
5-Thymidylic acid + Water → Phosphate + Thymidine
LEFT_TO_RIGHT
Uridine phosphorylase 2
quinol
thioredoxin
thioredoxin disulfide
Thymidine phosphorylase
Adenosine diphosphate
3.6.1.6
false
3.6.1.6
Water + dTDP → 5-Thymidylic acid + Phosphate
LEFT_TO_RIGHT
2.7.4.6
false
2.7.4.6
Adenosine triphosphate + dTDP ↔ Adenosine diphosphate + Thymidine 5'-triphosphate
REVERSIBLE
2.1.1.45
false
2.1.1.45
5,10-Methylene-THF + dUMP → 5-Thymidylic acid + Dihydrofolic acid
LEFT_TO_RIGHT
2.1.1.45
false
2.1.1.45
5-Thymidylic acid + Adenosine triphosphate ↔ Adenosine diphosphate + dTDP
REVERSIBLE
84-21-9
CAS
2.7.1.21
false
2.7.1.21
Adenosine triphosphate + Deoxyuridine → Adenosine diphosphate + dUMP
LEFT_TO_RIGHT
Q5EBM0
UniProt
3.5.4.12
false
3.5.4.12
Water + dCMP → Ammonia + dUMP
LEFT_TO_RIGHT
14075-00-4
CAS
CHEBI:15422
ChEBI
Homo sapiens
5585
ChemSpider
HMDB0000828
HMDB
1.0
Ribonucleoside-diphosphate reductase subunit M2 B
3.6.1.6
false
3.6.1.6
Uridine triphosphate + Water → Phosphoric acid + Uridine 5'-diphosphate
LEFT_TO_RIGHT
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O
CHEBI:16509
ChEBI
439216
PubChem-compound
1.0
4489
ChemSpider
CHEBI:16526
ChEBI
CPD-8130
BioCyc
C00620
KEGG Compound
CHEBI:16761
ChEBI
160663
PubChem-compound
2.7.1.48
false
2.7.1.48
Adenosine triphosphate + Uridine → Adenosine diphosphate + Uridine 5'-monophosphate
LEFT_TO_RIGHT
1.0
1173-82-6
CAS
1.0
439236
PubChem-compound
SMILES
O=C1C=CC(=O)C=C1
CHEBI:17677
ChEBI
278
PubChem-compound
Thymidine
C00881
KEGG Compound
5886
PubChem-compound
CHEBI:17672
ChEBI
Phosphate
CHEBI:27468
ChEBI
280
PubChem-compound
491-97-4
CAS
CHEBI:16311
ChEBI
C00415
KEGG Compound
58601
ChemSpider
P32320
UniProt
P32321
UniProt
Cytidine triphosphate
SubPathwayInput
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O
SMILES
N[C@@H](CCC(N)=O)C(O)=O
17210-42-3
CAS
2.0
1.0
Cytosolic purine 5'-nucleotidase
CHEBI:28542
ChEBI
1061
PubChem-compound
63-39-8
CAS
CHEBI:17659
ChEBI
65-71-4
CAS
C00429
KEGG Compound
Deoxycytidine
HMDB0001967
HMDB
HMDB0000641
HMDB
SMILES
OC(=O)[C@@H]1CC(=O)NC(=O)N1
quinol
CHEBI:1670
ChEBI
HMDB0003911
HMDB