Glutathione synthetase
HMDB0061365
HMDB
CHEBI:16015
ChEBI
HMDB0061366
HMDB
30572
ChemSpider
6022
PubChem-compound
17215925
ChemSpider
7722-84-1
CAS
SMILES
N[C@@H](CS)C(O)=O
1.0
937
ChemSpider
1.0
CYS
BioCyc
32980411
ChemSpider
388596
ChemSpider
(5-L-Glutamyl)-L-amino acid
C8H14N2O5S
γ-Glutamylcysteine
250.06235
Methyl-S-cystein
Glutathione
2.0
HMDB0003125
HMDB
255
ChemSpider
SMILES
O
SMILES
OO
2.0
Pyroglutamic acid
Glutathione reductase, mitochondrial
ReactionCatalysis28
ACTIVATION
CHEBI:50619
ChEBI
1.0
Glutathione reductase, mitochondrial
ReactionCatalysis26
ACTIVATION
Caspase-7
HMDB0061370
HMDB
C01419
KEGG Compound
HMDB0000538
HMDB
1004
PubChem-compound
ATP
BioCyc
1.0
Cysteinylglycine
Caspase-7
ADP
BioCyc
2.0
HMDB0061369
HMDB
HMDB0061367
HMDB
HMDB0061368
HMDB
1.0
P07203
UniProt
Glycine
53-59-8
CAS
Gamma-glutamyltransferase 6
7127
ChemSpider
5742
ChemSpider
CHEBI:17561
ChEBI
CHEBI:16474
ChEBI
P48637
UniProt
GO:0005829
GENE ONTOLOGY
C11347
KEGG Compound
950
ChemSpider
TransportCatalysis5386
ACTIVATION
C13645
KEGG Compound
Glutathione peroxidase 1
Glutathione S-transferase omega-2
2.0
PW000038
PathWhiz
5735
ChemSpider
Glutathione synthetase
CHEBI:16240
ChEBI
5862
PubChem-compound
Hydrogen bromide
1.0
C21H30N7O17P3
NADPH
745.0911
6.3.2.2
false
6.3.2.2
Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Phosphoric acid + γ-Glutamylcysteine
LEFT_TO_RIGHT
6.3.2.3
false
6.3.2.3
Adenosine triphosphate + Glycine + γ-Glutamylcysteine → Adenosine diphosphate + Glutathione + Phosphoric acid
LEFT_TO_RIGHT
5-oxoprolinase
3.5.2.9
false
3.5.2.9
Adenosine triphosphate + Pyroglutamic acid + 2 Water → Adenosine diphosphate + L-Glutamic acid + Phosphoric acid
LEFT_TO_RIGHT
C21H28N7O17P3
NADP
743.07544
GLY
BioCyc
ReactionCatalysis58
ACTIVATION
NADPH
BioCyc
Gamma-glutamylcyclotransferase
1.0
CHEBI:16856
ChEBI
CHEBI:16977
ChEBI
124886
PubChem-compound
L-Glutamic acid
SubPathwayOutput
Cytosol
Q02978
UniProt
ReactionCatalysis56
ACTIVATION
ReactionCatalysis57
ACTIVATION
C03740
KEGG Compound
ReactionCatalysis54
ACTIVATION
ReactionCatalysis55
ACTIVATION
HMDB0000574
HMDB
2.0
2.0
HMDB0000217
HMDB
7664-38-2
CAS
GO:0005886
GENE ONTOLOGY
1.0
C2H5NO2
Glycine
75.03203
1.0
3.4.11.2
false
3.4.11.2
Methyl-S-Cysteinylglycine + Water → Glycine + Methyl-S-cystein
LEFT_TO_RIGHT
Reaction2268
false
S-(methyl)glutathione + Water → L-Glutamic acid + Methyl-S-Cysteinylglycine
LEFT_TO_RIGHT
C00009
KEGG Compound
Glutathione
C00008
KEGG Compound
1.0
CPD-589
BioCyc
C00127
KEGG Compound
C00006
KEGG Compound
2.0
CHEBI:18009
ChEBI
C00001
KEGG Compound
1.0
4.0
56-41-7
CAS
C00005
KEGG Compound
C20H32N6O12S2
Oxidized glutathione
612.152
C00002
KEGG Compound
Mitochondrial 2-oxoglutarate/malate carrier protein
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
P48506
UniProt
HMDB0000221
HMDB
P48507
UniProt
5257127
PubChem-compound
C10H17N3O6S
Glutathione
307.0838
55290163
PubChem-compound
GO:0005759
GENE ONTOLOGY
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
GLT
BioCyc
γ-Glutamylcysteine
1.0
1.0
C18447
KEGG Compound
53-57-6
CAS
CHEBI:39275
ChEBI
SMILES
Br
Gamma-glutamylcyclotransferase
Adenosine triphosphate
1.0
5950
PubChem-compound
5-oxoprolinase
SMILES
OP(O)(O)=O
6083
ChemSpider
P15144
UniProt
1.0
HMDB0031524
HMDB
NAD(P)
BioCyc
5957
PubChem-compound
C5H10N2O3S
Cysteinylglycine
178.04121
10035-10-6
CAS
SMILES
C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O
SMILES
CSC(N)C(O)=O
CH3Br
Bromomethane
93.94181
SMILES
CS[C@@H](N)CNCC(O)=O
1.0
SMILES
CSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O
Cysteine Metabolism
SubPathway
1.0
SMILES
C[C@H](N)C(O)=O
SubPathwayInteraction800
SubPathway800Reaction
SubPathwayReaction
Gamma-glutamyltransferase 6
1.0
56-65-5
CAS
5653
ChemSpider
L-Glutamic acid
C00027
KEGG Compound
PW000074
PathWhiz
C00025
KEGG Compound
HMDB0000123
HMDB
CHEBI:26078
ChEBI
C5H7NO3
Pyroglutamic acid
129.04259
SMP0000072
SMPDB
5-Oxoprolinuria
HMDB0000125
HMDB
Aminopeptidase N
Taurine and Hypotaurine Metabolism
SubPathway
Adenosine triphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
2.3.2.4
false
2.3.2.4
γ-Glutamylcysteine → L-Cysteine + Pyroglutamic acid
LEFT_TO_RIGHT
GO:0005737
GENE ONTOLOGY
Glutamate--cysteine ligase regulatory subunit
Reaction2270
false
Glutathione + L-amino acid → (5-L-Glutamyl)-L-amino acid + Cysteinylglycine
LEFT_TO_RIGHT
2.3.2.4
false
2.3.2.4
(5-L-Glutamyl)-L-amino acid → L-amino acid + Pyroglutamic acid
LEFT_TO_RIGHT
Glutamate--cysteine ligase catalytic subunit
1.0
1.0
70-18-8
CAS
OXIDIZED-GLUTATHIONE
BioCyc
SubPathwayInteraction798
SubPathway798Reaction
SubPathwayReaction
BrH
Hydrogen bromide
79.92616
SubPathwayInteraction799
SubPathwayReaction
SubPathway799Reaction
52-90-4
CAS
Gamma-glutamylcyclotransferase
98-79-3
CAS
2.0
O75223
UniProt
C00037
KEGG Compound
ReactionCatalysis2138
ACTIVATION
SMILES
N[C@@H](CS)C(=O)NCC(O)=O
1.0
ReactionCatalysis2137
ACTIVATION
5255796
PubChem-compound
ReactionCatalysis2139
ACTIVATION
C00041
KEGG Compound
110467
ChemSpider
HYDROGEN-PEROXIDE
BioCyc
Mitochondrial Matrix
SMILES
CBr
C11H19N3O6S
S-(methyl)glutathione
321.09946
2.0
ReactionCatalysis2136
ACTIVATION
C5H12N2O2S
Methyl-S-Cysteinylglycine
164.06195
1.0
HMDB0001341
HMDB
C3H7NO2S
Methyl-S-cystein
121.01975
C8H14N2O5
(5-L-Glutamyl)-L-amino acid
218.09027
C3H7NO2
L-amino acid
89.047676
103128
ChemSpider
Glutamate--cysteine ligase catalytic subunit
CHEBI:17515
ChEBI
Cysteinylglycine
1.0
5675
ChemSpider
Aminopeptidase N
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
763
ChemSpider
HMDB0000267
HMDB
Mitochondrial 2-oxoglutarate/malate carrier protein
Adenosine diphosphate
C00051
KEGG Compound
HMDB0000148
HMDB
ReactionCatalysis2141
ACTIVATION
Cytoplasm
ReactionCatalysis2140
ACTIVATION
2.0
ReactionCatalysis2142
ACTIVATION
SMP0000013
SMPDB
SMILES
OC(=O)[C@@H]1CCC(=O)N1
Gamma-glutamyltransferase 6
Glutathione S-transferase omega-2
5-oxoprolinase
784
PubChem-compound
CHEBI:15422
ChEBI
Homo sapiens
2922-56-7
CAS
SMILES
N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O
1.0
7732-18-5
CAS
CYS-GLY
BioCyc
1.0
6323
PubChem-compound
Gamma-glutamyltransferase 6
123938
PubChem-compound
Hydrogen peroxide
19246-18-5
CAS
(5-L-Glutamyl)-L-amino acid
56-86-0
CAS
115260
PubChem-compound
Adenosine diphosphate
SMP0000021
SMPDB
SMP0000143
SMPDB
Water
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
1.8.1.7
false
1.8.1.7
NADPH + Oxidized glutathione ↔ 2 Glutathione + NADP
REVERSIBLE
C10H16N5O13P3
Adenosine triphosphate
506.99576
Phosphoric acid
CHEBI:17858
ChEBI
1.11.1.9
false
1.11.1.9
2 Glutathione + Hydrogen peroxide → Oxidized glutathione + 2 Water
LEFT_TO_RIGHT
1.0
56-40-6
CAS
7405
PubChem-compound
Phosphoric acid
CHEBI:16761
ChEBI
1.0
γ-Glutamylcysteine
O14841
UniProt
2.0
CHEBI:15428
ChEBI
Q9H4Y5
UniProt
S-(methyl)glutathione
Aminopeptidase N
1.0
3.4.11.2
false
3.4.11.2
Cysteinylglycine + Water → Glycine + L-Cysteine
LEFT_TO_RIGHT
Glutamate--cysteine ligase
P55210
UniProt
9606
TAXONOMY
962
PubChem-compound
P00390
UniProt
5800
ChemSpider
Glutathione
74-83-9
CAS
636-58-8
CAS
979
ChemSpider
1.0
1.0
Transport14569
false
Glutathione (↔) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix
LEFT_TO_RIGHT
440103
PubChem-compound
730
ChemSpider
NADP
Water
H3O4P
Phosphoric acid
97.9769
Glutamate Metabolism
SubPathway
L-amino acid
PW000018
PathWhiz
Glutathione
HMDB0002111
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
Gamma-glutamyltransferase 6
CHEBI:15377
ChEBI
Cell Membrane
L-Cysteine
SubPathwayInput
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
L-amino acid
5886
PubChem-compound
1.0
1.0
HMDB0003337
HMDB
Methyl-S-Cysteinylglycine
CHEBI:4047
ChEBI
Glutathione reductase, mitochondrial
1.0
Oxidized glutathione
111188
ChemSpider
Glutathione synthetase
Bromomethane
NADPH
389104
ChemSpider
C3H7NO2S
L-Cysteine
121.01975
27025-41-8
CAS
PW000003
PathWhiz
C00097
KEGG Compound
5875-41-2
CAS
Glycine
HMDB0000078
HMDB
439498
PubChem-compound
1.0
22833512
PubChem-compound
HMDB0001049
HMDB
H2O
Water
18.010565
H2O2
Hydrogen peroxide
34.005478
SMILES
NCC(O)=O
22169024
PubChem-compound
CHEBI:47266
ChEBI
C00669
KEGG Compound
C01879
KEGG Compound
Glutamate--cysteine ligase regulatory subunit
Glutathione peroxidase 1
Glutathione S-transferase omega-2
L-GAMMA-GLUTAMYLCYSTEINE
BioCyc
SMILES
NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
Glutathione peroxidase 1
CHEBI:18183
ChEBI
Q6P531
UniProt
1.0
SMILES
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
Reaction587
false
Bromomethane + Glutathione → Hydrogen bromide + S-(methyl)glutathione
LEFT_TO_RIGHT
HMDB0002142
HMDB