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Sodium/potassium-
transporting
ATPase subunit
gamma
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
K
+
K
+
Ca
+
Sodium/potassium-
transporting
ATPase subunit
beta-3
Sodium channel
protein type 5
subunit alpha
Beta-2-
syntrophin
Beta-1-
syntrophin
Alpha-1-
syntrophin
Cytochrome P450
2C19
Cytochrome P450
2C9
Cytochrome P450
1A2
Cytochrome P450
2C19
Cytochrome P450
2E1
Epoxide
hydrolase 1
Cytochrome P450
2C9
Cytochrome P450
2C19
Cytochrome P450
3A4
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-4
UDP-
glucuronosyltransferase
1-6
UDP-
glucuronosyltransferase
1-9
Catechol O-
methyltransferase
NAD(P)H
dehydrogenase
[quinone] 1
Tropomyosin
alpha-1 chain
Tropomyosin
beta chain
Beta-1
adrenergic
receptor
cAMP-dependent
protein kinase
type I-alpha
regulatory
subunit
Voltage-
dependent
L-type calcium
channel subunit
alpha-1C
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Ryanodine
receptor 2
Muscarinic
acetylcholine
receptor M2
Cardiac
phospholamban
Sarcoplasmic/endoplasmic
reticulum
calcium ATPase
2
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-2
Inward
rectifier
potassium
channel 4
Potassium
voltage-gated
channel
subfamily D
member 3
Kv channel-
interacting
protein 2
Potassium
voltage-gated
channel
subfamily A
member 5
Disks large
homolog 1
Potassium
voltage-gated
channel
subfamily KQT
member 1
Potassium
voltage-gated
channel
subfamily E
member 1
Potassium
voltage-gated
channel
subfamily E
member 2
ATP-binding
cassette
sub-family C
member 8
ATP-sensitive
inward
rectifier
potassium
channel 8
ATP-sensitive
inward
rectifier
potassium
channel 11
ATP-binding
cassette
sub-family C
member 9
Potassium
channel
subfamily K
member 1
Sodium/calcium
exchanger 1
Potassium/sodium
hyperpolarization-
activated
cyclic
nucleotide-
gated channel 4
Sodium channel
protein type 5
subunit alpha
Beta-2-
syntrophin
Beta-1-
syntrophin
Alpha-1-
syntrophin
Voltage-
dependent
T-type calcium
channel subunit
alpha-1H
Voltage-
dependent
T-type calcium
channel subunit
alpha-1G
Sodium/calcium
exchanger 1
cAMP-dependent
protein kinase
catalytic
subunit alpha
Sodium/potassium-
transporting
ATPase subunit
beta-1
Inward
rectifier
potassium
channel 2
Phenytoin
Phenytoin
O
2
NADPH
H
+
Phenytoin arene-oxide
H
2
O
NADP
H
2
O
Phenytoin dihydrodiol
Hydroxyphenytoin
Phenytoin catechol
O
2
NADPH
H
+
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
4-Hydroxyphenytoin glucuronide
Uridine
5'-diphosphate
S-
Adenosylmethionine
Phenytoin methylcatechol
S-
Adenosylhomocysteine
NADP
Phenytoin quinone
NADPH
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Magnesium
FAD
Ca
+
Na
+
Na
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
K
+
Ca
+
Ca
+
Na
+
Na
+