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Ca
+
Na
+
Ca
+
Ca
+
Na
+
K
+
K
+
Sodium-
dependent
serotonin
transporter
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] B
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] B
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] B
Aldehyde
oxidase
Cytochrome P450
2D6
Cytochrome P450
3A7
Cytochrome P450
2C19
Cytochrome P450
2D6
Cytochrome P450
2D6
Alpha-1A
adrenergic
receptor
5-
hydroxytryptamine
receptor 1A
D(1A) dopamine
receptor
Beta-endorphin
Mu-type opioid
receptor
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-4
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Potassium
voltage-gated
channel
subfamily D
member 2
Kv channel-
interacting
protein 2
Beta-endorphin
Glutamate
[NMDA] receptor
subunit zeta-1
Glutamate
[NMDA] receptor
subunit
epsilon-1
Glutamate
[NMDA] receptor
subunit 3A
Sodium-
dependent
noradrenaline
transporter
Sodium-
dependent
serotonin
transporter
Sodium-
dependent
dopamine
transporter
Pro-
opiomelanocortin
Neuroendocrine
convertase 2
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Citalopram
Citalopram
H
2
O
O
2
Citalopram aldehyde
Dimethylamine
H
2
O
2
N-Desmethylcitalopram
H
2
O
O
2
Methylammonium
H
2
O
2
Didemethylcitalopram
H
2
O
O
2
NH
3
H
2
O
2
H
2
O
O
2
Citalopram propionic acid
H
2
O
2
O
2
NADH
H
2
O
Formaldehyde
NAD
O
2
NADH
H
2
O
Formaldehyde
NAD
O
2
H
2
O
Citalopram N-oxide
H
2
O
2
FAD
FAD
FAD
FAD
FAD
FAD
FAD
Molybdopterin
2Fe-2S
Heme
Heme
Heme
Heme
Heme
Norepinephrine
Serotonin
Dopamine
Ca
+
Na
+
K
+
Ca
+
Ca
+
Norepinephrine
Serotonin
Na
+
Na
+
Na
+
Na
+
Dopamine
Na
+
Na
+
ATP
H
2
O
Na
+
K
+
ADP
P
i
Na
+
K
+
Sodium channel
protein type 10
subunit alpha
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium channel
subunit beta-1
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
gamma
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Axon Terminal
Mitochondrion outer membrane
Synaptic Vesicle
Presynaptic Neuron
Postsynaptic Neuron
Synaptic Cleft
Neuron
Neuron Axon
Action Potential
Membrane Potential (mV)
Resting Potential
-70
Time
+40
0
Depolarization
Peak Action Potential
Repolarization
Hyperpolarization