ReactionCoupledTransportCatalysis7
ACTIVATION
Vinblastine
SubPathwayInhibitor
SubPathwayActivator
Vinblastine
ReactionCoupledTransportCatalysis8
ACTIVATION
6022
PubChem-compound
ReactionCoupledTransportCatalysis9
ACTIVATION
C44H56N4O8
Desacetylvinblastine
768.4098
937
ChemSpider
Vinblastine
CPD-8587
BioCyc
241903
PubChem-compound
Multidrug resistance-associated protein 1
SMILES
O
Vinblastine Inhibition of Tubulin
InhibitorySubPathway
BiologicalState31
Homo sapiens, Liver
Antigen p53 Induction
ActivatingSubPathway
Cyclin-dependent kinase inhibitor 1 induction
ActivatingSubPathway
Vinblastine Action Pathway
211446
ChemSpider
Adenosine triphosphate
HMDB0001341
HMDB
Transport242
false
Vinblastine (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Cyclin-dependent kinase inhibitor 1
SubPathwayActivation
Q92887
UniProt
HMDB0000538
HMDB
Canalicular multispecific organic anion transporter 1
Cytochrome P450 3A4
1.0
Water
ATP
BioCyc
1.0
1.0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
O15438
UniProt
Q9H4B7
UniProt
Multidrug resistance protein 1
1.0
Cytoplasm
ADP
BioCyc
Q15311
UniProt
HMDB0014710
HMDB
CHEBI:15422
ChEBI
BTO:0000759
BRENDA TISSUE ONTOLOGY
1.0
Homo sapiens
5742
ChemSpider
Multidrug resistance protein 1
7732-18-5
CAS
P68363
UniProt
GO:0005829
GENE ONTOLOGY
Tubulin beta-1 chain
865-21-4
CAS
RalA-binding protein 1
C46H58N4O9
Vinblastine
810.42035
Reaction2249
false
Vinblastine → Desacetylvinblastine
LEFT_TO_RIGHT
1.0
CHEBI:27375
ChEBI
Phosphate
SMP0000436
SMPDB
C10H16N5O13P3
Adenosine triphosphate
506.99576
Q5T3U5
UniProt
O4P
Phosphate
94.95342
1.0
CHEBI:16761
ChEBI
Vinblastine
Tubulin alpha-1B chain
9606
TAXONOMY
962
PubChem-compound
1.0
Multidrug resistance-associated protein 1
Canalicular multispecific organic anion transporter 1
Tubulin alpha-1B chain
5800
ChemSpider
Canalicular multispecific organic anion transporter 2
Cytosol
SMILES
[O-]P([O-])([O-])=O
GO:0005886
GENE ONTOLOGY
HMDB0002111
HMDB
ReactionCoupledTransportCatalysis10
ACTIVATION
Desacetylvinblastine
ReactionCoupledTransportCatalysis12
ACTIVATION
P04637
UniProt
SMILES
[H][C@@]12N(C)C3=C(C=C(C(OC)=C3)[C@]3(C[C@@H]4CN(C[C@](O)(CC)C4)CCC4=C3NC3=CC=CC=C43)C(=O)OC)[C@@]11CCN3CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]2(O)C(=O)OC)[C@@]13[H]
ReactionCoupledTransportCatalysis11
ACTIVATION
Tubulin beta-1 chain
Cell Membrane
CHEBI:15377
ChEBI
C00009
KEGG Compound
Cyclin-dependent kinase inhibitor 1
C00008
KEGG Compound
Multidrug resistance-associated protein 1
Canalicular multispecific organic anion transporter 2
14265-44-2
CAS
Cellular tumor antigen p53
P08684
UniProt
HMDB0061054
HMDB
C00001
KEGG Compound
HMDB0001429
HMDB
58-64-0
CAS
Tubulin
SubPathwayInhibition
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
Liver
C07201
KEGG Compound
TransportCatalysis202
ACTIVATION
TransportCatalysis201
ACTIVATION
TransportCatalysis200
ACTIVATION
SMILES
[H][C@]12CN(C[C@](O)(CC)C1)CCC1=C(NC3=CC=CC=C13)[C@@](C2)(C(=O)OC)C1=C(OC)C=C2N(C)[C@@H]3C4(CCN5CC=C[C@](CC)([C@@H]45)[C@@H](O)[C@]3(O)C(=O)OC)C2=C1
PW000241
PathWhiz
RalA-binding protein 1
Multidrug resistance-associated protein 7
Canalicular multispecific organic anion transporter 1
Extracellular Space
H2O
Water
18.010565
5957
PubChem-compound
ReactionCatalysis2114
ACTIVATION
Cytochrome P450 3A4
1.0
1061
PubChem-compound
SubPathwayControl472
SubPathway472Control
InhibitorySubPathwayControl
SubPathwayControl473
SubPathway473Control
ActivatingSubPathwayControl
P38936
UniProt
SubPathwayControl474
SubPathway474Control
ActivatingSubPathwayControl
Multidrug resistance protein 1
56-65-5
CAS
P33527
UniProt
P08183
UniProt
3.6.3.44
false
3.6.3.44
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
Adenosine diphosphate
ReactionCoupledTransport10
false
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
C10H15N5O10P2
Adenosine diphosphate
427.02942
ReactionCoupledTransport9
false
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
ReactionCoupledTransport12
false
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
GO:0005615
GENE ONTOLOGY
ReactionCoupledTransport8
false
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
ReactionCoupledTransport11
false
Adenosine triphosphate + Vinblastine + Water → Adenosine diphosphate + Phosphate + Vinblastine
LEFT_TO_RIGHT
GO:0005737
GENE ONTOLOGY
71315532
PubChem-compound
Multidrug resistance-associated protein 7
Cellular tumor antigen p53
SubPathwayActivation