6022
PubChem-compound
SubPathwayControl541
SubPathway541Control
InhibitorySubPathwayControl
Vincristine
SubPathwayInhibitor
SubPathwayActivator
937
ChemSpider
CPD-8587
BioCyc
Multidrug resistance-associated protein 1
5978
PubChem-compound
SMILES
O
Vincristine Action Pathway
Adenosine triphosphate
HMDB0001341
HMDB
Transport243
false
Vincristine (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Cyclin-dependent kinase inhibitor 1
SubPathwayActivation
Q92887
UniProt
HMDB0000538
HMDB
Canalicular multispecific organic anion transporter 1
1.0
Vincristine
ATP
BioCyc
Water
1.0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
O15438
UniProt
Q9H4B7
UniProt
Multidrug resistance protein 1
1.0
Cytoplasm
SMILES
[H][C@@]12N3CC[C@@]11C4=CC(=C(OC)C=C4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=CC=CC=C21)C(=O)OC
ADP
BioCyc
Q15311
UniProt
CHEBI:15422
ChEBI
1.0
Homo sapiens
5742
ChemSpider
Multidrug resistance protein 1
7732-18-5
CAS
P68363
UniProt
GO:0005829
GENE ONTOLOGY
RalA-binding protein 1
Phosphate
Tubulin alpha-1B chain
C10H16N5O13P3
Adenosine triphosphate
506.99576
SubPathwayControl551
ActivatingSubPathwayControl
SubPathway551Control
SMP0000437
SMPDB
Q5T3U5
UniProt
SubPathwayControl552
ActivatingSubPathwayControl
SubPathway552Control
O4P
Phosphate
94.95342
HMDB0014681
HMDB
1.0
CHEBI:16761
ChEBI
Vincristine
57-22-7
CAS
Vincristine inhibition of Tubulin
InhibitorySubPathway
9606
TAXONOMY
962
PubChem-compound
Multidrug resistance-associated protein 1
Canalicular multispecific organic anion transporter 1
Tubulin beta-1 chain
Tubulin alpha-1B chain
5800
ChemSpider
Vincristine
Canalicular multispecific organic anion transporter 2
Cytosol
CHEBI:28445
ChEBI
SMILES
[O-]P([O-])([O-])=O
GO:0005886
GENE ONTOLOGY
Vincristine activation of Cellular tumor antigen p53
ActivatingSubPathway
Vincristine activation of Cyclin-dependent kinase inhibitor 1
ActivatingSubPathway
HMDB0002111
HMDB
P04637
UniProt
Tubulin beta-1 chain
Cell Membrane
CHEBI:15377
ChEBI
C00009
KEGG Compound
Cyclin-dependent kinase inhibitor 1
5758
ChemSpider
C00008
KEGG Compound
Canalicular multispecific organic anion transporter 2
Multidrug resistance-associated protein 1
14265-44-2
CAS
Cellular tumor antigen p53
ReactionCoupledTransportCatalysis18
ACTIVATION
C00001
KEGG Compound
58-64-0
CAS
HMDB0001429
HMDB
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
ReactionCoupledTransportCatalysis25
ACTIVATION
1.0
TransportCatalysis205
ACTIVATION
GO:0005634
GENE ONTOLOGY
ReactionCoupledTransportCatalysis27
ACTIVATION
TransportCatalysis204
ACTIVATION
ReactionCoupledTransportCatalysis26
ACTIVATION
TransportCatalysis203
ACTIVATION
ReactionCoupledTransportCatalysis21
ACTIVATION
Tubulin
SubPathwayInhibition
ReactionCoupledTransportCatalysis23
ACTIVATION
PW000242
PathWhiz
RalA-binding protein 1
ReactionCoupledTransport27
false
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
ReactionCoupledTransport26
false
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
Multidrug resistance-associated protein 7
Canalicular multispecific organic anion transporter 1
C07204
KEGG Compound
Extracellular Space
ReactionCoupledTransport21
false
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
ReactionCoupledTransport23
false
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
H2O
Water
18.010565
ReactionCoupledTransport25
false
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
5957
PubChem-compound
1.0
Nucleus
1061
PubChem-compound
P38936
UniProt
Multidrug resistance protein 1
56-65-5
CAS
3.6.3.44
false
3.6.3.44
Adenosine triphosphate + Vincristine + Water → Adenosine diphosphate + Phosphate + Vincristine
LEFT_TO_RIGHT
P33527
UniProt
1.0
P08183
UniProt
Adenosine diphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
Multidrug resistance-associated protein 7
Cellular tumor antigen p53
SubPathwayActivation
C46H56N4O10
Vincristine
824.39966