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Solute carrier
family 22
member 16
Multidrug
resistance
protein 1
Multidrug
resistance-
associated
protein 1
Canalicular
multispecific
organic anion
transporter 1
ATP-binding
cassette
sub-family G
member 2
RalA-binding
protein 1
NAD(P)H
dehydrogenase
[quinone] 1
NADPH--
cytochrome P450
reductase
Xanthine
dehydrogenase/oxidase
Carbonyl
reductase
[NADPH] 1
Carbonyl
reductase
[NADPH] 3
Aldo-keto
reductase
family 1 member
C3
Alcohol
dehydrogenase
[NADP(+)]
Nitric oxide
synthase,
endothelial
Xanthine
dehydrogenase/oxidase
NAD(P)H
dehydrogenase
[quinone] 1
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 2,
mitochondrial
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 3,
mitochondrial
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 7,
mitochondrial
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 2,
mitochondrial
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 3,
mitochondrial
NADH
dehydrogenase
[ubiquinone]
iron-sulfur
protein 7,
mitochondrial
Doxorubicin
Doxorubicin
Doxorubicin
Doxorubicin-semiquinone
Doxorubicin
Doxorubicine hydroxyaglycone
Doxorubicinol hydroxyaglycone
Doxorubicinol deoxaglycone
Doxorubicin-semiquinone
NADPH
Doxorubicinol
NADP
NADH
NAD
NADH
NAD
NADH
NAD
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
FAD
FAD
Flavin
Mononucleotide
FAD
2Fe-2S
Molybdopterin
Heme
FAD
Flavin
Mononucleotide
Tetrahydrobiopterin
FAD
2Fe-2S
Molybdopterin
FAD
Sarcoplasmic reticulum
Mitochondrion
Mitochondria
SLC22A16
ABCB1
ABCC1
ABCC2
ABCG2
RALBP1
NQO1
POR
XDH
CBR1
CBR3
AKR1C3
AKR1A1
NOS3
XDH
NQO1
NDUFS2
NDUFS3
NDUFS7
NDUFS2
NDUFS3
NDUFS7
Doxorubicin
Doxorubicin
Doxorubicin
Doxorubicin-
semiquinone
Doxorubicin
Doxorubicine
hydroxyaglycone
Doxorubicinol
hydroxyaglycone
Doxorubicinol
deoxaglycone
Doxorubicin-
semiquinone
NADPH
Doxorubicinol
NADP
NADH
NAD
NADH
NAD
NADH
NAD
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate