HMDB0061088
HMDB
Endoplasmic Reticulum Membrane
937
ChemSpider
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
1.0
5682
ChemSpider
UDP
BioCyc
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
Reaction2066
false
Artemether + NADH + Oxygen → Dihydroartemisinin (DHA) + Formaldehyde + NAD + Water
LEFT_TO_RIGHT
O60656
UniProt
439153
PubChem-compound
SMILES
O
Cytochrome P450 3A4
Dihydroartemisinin glucuronide
2616-64-0
CAS
Cytochrome P450 3A4
Cytochrome P450 3A5
HMDB0000935
HMDB
C00167
KEGG Compound
Uridine diphosphate glucuronic acid
71316128
PubChem-compound
P16662
UniProt
C16H26O5
Artemether
298.178
NAD
C9H14N2O12P2
Uridine 5'-diphosphate
404.0022
CHEBI:15846
ChEBI
SMP0000651
SMPDB
HMDB0015643
HMDB
BTO:0000759
BRENDA TISSUE ONTOLOGY
Homo sapiens
SMILES
C[C@H]1CCC2[C@H](C)[C@H](O)O[C@H]3OC4(C)CC[C@H]1[C@]23OO4
388299
ChemSpider
7732-18-5
CAS
CHEBI:17200
ChEBI
1.0
1.0
952
ChemSpider
HMDB0001487
HMDB
Water
O2
Oxygen
31.98983
GO:0005789
GENE ONTOLOGY
CH2O
Formaldehyde
30.010565
1.0
1.0
16522
ChemSpider
CHEBI:16908
ChEBI
UDP-GLUCURONATE
BioCyc
HMDB0061351
HMDB
6031
PubChem-compound
BiologicalState10
Homo sapiens, Liver
SMILES
C[C@@H]1CC[C@H]2[C@@H](C)C(O[C@@H]3O[C@H]([C@@H](O)[C@H](O)[C@@H]3O)C(O)=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4
C00067
KEGG Compound
7782-44-7
CAS
HMDB0001377
HMDB
2.4.1.17
false
2.4.1.17
Dihydroartemisinin (DHA) + Uridine diphosphate glucuronic acid → Dihydroartemisinin glucuronide + Uridine 5'-diphosphate
LEFT_TO_RIGHT
SMILES
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O
SMILES
[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H](OC)[C@@H]2C)O4
1.0
P20815
UniProt
68911
PubChem-compound
CHEBI:195280
ChEBI
UDP-glucuronosyltransferase 1-9
9606
TAXONOMY
962
PubChem-compound
C15H22N2O18P2
Uridine diphosphate glucuronic acid
580.0343
FORMALDEHYDE
BioCyc
1.0
Artemether
58-98-0
CAS
C15H24O5
Dihydroartemisinin (DHA)
284.16238
CPD-6641
BioCyc
5893
PubChem-compound
Cytochrome P450 3A5
58-68-4
CAS
1.0
SMILES
O=O
UDP-glucuronosyltransferase 1-9
SMILES
C=O
UDP-glucuronosyltransferase 2B7
HMDB0001426
HMDB
692
ChemSpider
1.0
HMDB0002111
HMDB
HMDB0000295
HMDB
5809
ChemSpider
NADH
CHEBI:15377
ChEBI
C00007
KEGG Compound
CHEBI:15379
ChEBI
Oxygen
P08684
UniProt
C21H32O11
Dihydroartemisinin glucuronide
460.19446
Formaldehyde
712
PubChem-compound
C00001
KEGG Compound
62138
ChemSpider
1.0
C00004
KEGG Compound
C00003
KEGG Compound
Liver
17473
PubChem-compound
198976-06-6
CAS
UDP-glucuronosyltransferase 2B7
C21H28N7O14P2
NAD
664.11694
ReactionCatalysis1937
ACTIVATION
ReactionCatalysis1936
ACTIVATION
HMDB0000902
HMDB
C00015
KEGG Compound
SMILES
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)N1C=CC(=O)NC1=O
C21H29N7O14P2
NADH
665.12476
H2O
Water
18.010565
Uridine 5'-diphosphate
NADH
BioCyc
Dihydroartemisinin (DHA)
Artemether Metabolism Pathway
NAD
BioCyc
CHEBI:16842
ChEBI
977
PubChem-compound
CHEBI:17659
ChEBI
ReactionCatalysis1948
ACTIVATION
71963-77-4
CAS
53-84-9
CAS
ReactionCatalysis1949
ACTIVATION
50-00-0
CAS
PW000627
PathWhiz