Q92934
UniProt
E3 ubiquitin-protein ligase CBL
Interaction214
Ras activates RAF
Dasatinib Inhibition of BCR-ABL
Interaction213
BCR-ABL/GRB2/GAB2/SOS1 complex activates Ras
Tyrosine-protein kinase JAK2
Interaction216
MEK activates MAPK
Interaction215
RAF activates MEK
2323020
ChemSpider
Q9UQC2
UniProt
Interaction218
BCR-ABL/CRK/CRKL/CBL/PI3K complex activates Akt
RAF
302962-49-8
CAS
Interaction217
BCR-ABL/GRB2/GAB2/SOS1 complex activates BCR-ABL/CRK/CRKL/CBL/PI3K complex
Ras
RAF
MEK
Interaction219
Akt inhibits FOXO
direct_interaction
MEK
MAPK
Akt
Bcl-2-like protein 1
S-phase kinase-associated protein 2
SMILES
CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1
E3 ubiquitin-protein ligase CBL
Interaction221
S-phase kinase-associated protein 2 inhibits cyclin-dependent kinase inhibitor 1B
Serine/threonine-protein kinase mTOR
Interaction220
Akt activates S-phase kinase-associated protein 2
Interaction223
Serine/threonine-protein kinase mTOR activates 70 kDa ribosomal protein S6 kinase
Ribosomal protein S6 kinase beta-1
E3 ubiquitin-protein ligase Mdm2
Interaction222
Akt activates Serine/threonine-protein kinase mTOR
Interaction225
Bcl2-associated agonist of cell death inhibits Bcl-2-like protein 1
Q00987
UniProt
MAPK
Interaction224
Akt inhibits Bcl2-associated agonist of cell death
Interaction227
E3 ubiquitin-protein ligase Mdm2 inhibits Cellular tumor antigen p53
Interaction226
Akt activates E3 ubiquitin-protein ligase Mdm2
Interaction229
BCR-ABL/GRB2/GAB2/SOS1 complex activates Tyrosine-protein kinase JAK2
Interaction228
BCR-ABL/GRB2/GAB2/SOS1 complex activates STAT5A homodimer complex
Ras
P46527
UniProt
Cytoplasm
Bcl2-associated agonist of cell death
3062316
PubChem-compound
Interaction230
Tyrosine-protein kinase JAK2 activates STAT5A homodimer complex
S-phase kinase-associated protein 2
Interaction231
Tyrosine-protein kinase JAK2 activates Myc proto-oncogene protein
Interaction233
Dasatinib inhibits BCR-ABL
Homo sapiens
GRB2-associated-binding protein 2
P22681
UniProt
Phosphatidylinositol 3-kinase regulatory subunit alpha
Bcl2-associated agonist of cell death
O60674
UniProt
Q07817
UniProt
Adapter molecule crk
Dasatinib
P01106
UniProt
A8E194
UniProt
GRB2-associated-binding protein 2
CHEBI:49375
ChEBI
Akt
Cyclin-dependent kinase inhibitor 1B
P46109
UniProt
P46108
UniProt
S-phase kinase-associated protein 2
Q13309
UniProt
PW032594
PathWhiz
9606
TAXONOMY
E3 ubiquitin-protein ligase Mdm2
P62993
UniProt
HMDB0015384
HMDB
Bcl-2-like protein 1
Growth factor receptor-bound protein 2
Ribosomal protein S6 kinase beta-1
FOXO
BCR-ABL/CRK/CRKL/CBL/PI3K complex
P04637
UniProt
Crk-like protein
Cellular tumor antigen p53
Tyrosine-protein kinase JAK2
Signal transducer and activator of transcription 5A
Q07889
UniProt
Myc proto-oncogene protein
Myc proto-oncogene protein
Growth factor receptor-bound protein 2
P27986
UniProt
GO:0005634
GENE ONTOLOGY
Son of sevenless homolog 1
Son of sevenless homolog 1
SMP0031696
SMPDB
Adapter molecule crk
BCR-ABL/GRB2/GAB2/SOS1 complex
Bcr-abl1 fusion protein
C22H26ClN7O2S
Dasatinib
487.15573
Bcr-abl1 fusion protein
Phosphatidylinositol 3-kinase regulatory subunit alpha
Nucleus
Cellular tumor antigen p53
E3 ubiquitin-protein ligase Mdm2
FOXO
Signal transducer and activator of transcription 5A
Tyrosine-protein kinase JAK2
GO:0005737
GENE ONTOLOGY
P42345
UniProt
P23443
UniProt
Crk-like protein
P42229
UniProt
Serine/threonine-protein kinase mTOR
Cyclin-dependent kinase inhibitor 1B