Q92934
UniProt
E3 ubiquitin-protein ligase CBL
Interaction214
Ras activates RAF
Interaction213
BCR-ABL/GRB2/GAB2/SOS1 complex activates Ras
Tyrosine-protein kinase JAK2
Interaction216
MEK activates MAPK
Interaction215
RAF activates MEK
Q9UQC2
UniProt
Interaction218
BCR-ABL/CRK/CRKL/CBL/PI3K complex activates Akt
RAF
Interaction217
BCR-ABL/GRB2/GAB2/SOS1 complex activates BCR-ABL/CRK/CRKL/CBL/PI3K complex
Ras
RAF
MEK
Interaction219
Akt inhibits FOXO
direct_interaction
MEK
MAPK
SMILES
CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1
Akt
Bcl-2-like protein 1
S-phase kinase-associated protein 2
1.0
E3 ubiquitin-protein ligase CBL
Interaction221
S-phase kinase-associated protein 2 inhibits cyclin-dependent kinase inhibitor 1B
Serine/threonine-protein kinase mTOR
Interaction220
Akt activates S-phase kinase-associated protein 2
Interaction223
Serine/threonine-protein kinase mTOR activates 70 kDa ribosomal protein S6 kinase
Ribosomal protein S6 kinase beta-1
E3 ubiquitin-protein ligase Mdm2
Interaction222
Akt activates Serine/threonine-protein kinase mTOR
Interaction225
Bcl2-associated agonist of cell death inhibits Bcl-2-like protein 1
Q00987
UniProt
MAPK
Interaction224
Akt inhibits Bcl2-associated agonist of cell death
Interaction227
E3 ubiquitin-protein ligase Mdm2 inhibits Cellular tumor antigen p53
Interaction226
Akt activates E3 ubiquitin-protein ligase Mdm2
Ponatinib
Interaction229
BCR-ABL/GRB2/GAB2/SOS1 complex activates Tyrosine-protein kinase JAK2
Interaction228
BCR-ABL/GRB2/GAB2/SOS1 complex activates STAT5A homodimer complex
TransportCatalysis5937
ACTIVATION
Ras
P46527
UniProt
Transport16011
true
Ponatinib (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol
REVERSIBLE
Ponatinib
Cytoplasm
Transport16010
false
Ponatinib (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
Bcl2-associated agonist of cell death
Interaction230
Tyrosine-protein kinase JAK2 activates STAT5A homodimer complex
1.0
S-phase kinase-associated protein 2
Interaction231
Tyrosine-protein kinase JAK2 activates Myc proto-oncogene protein
Homo sapiens
24747381
ChemSpider
943319-70-8
CAS
GRB2-associated-binding protein 2
P22681
UniProt
Phosphatidylinositol 3-kinase regulatory subunit alpha
Interaction237
Ponatinib inhibits BCR-ABL
Multidrug resistance protein 1
Bcl2-associated agonist of cell death
O60674
UniProt
GO:0005829
GENE ONTOLOGY
Q07817
UniProt
Adapter molecule crk
C29H27F3N6O
Ponatinib
532.21985
P01106
UniProt
1.0
A8E194
UniProt
GRB2-associated-binding protein 2
24826799
PubChem-compound
Akt
Cyclin-dependent kinase inhibitor 1B
SMP0031700
SMPDB
P46109
UniProt
HMDB0240214
HMDB
P46108
UniProt
PW032598
PathWhiz
S-phase kinase-associated protein 2
Q13309
UniProt
9606
TAXONOMY
Ponatinib
E3 ubiquitin-protein ligase Mdm2
Cytosol
P62993
UniProt
Bcl-2-like protein 1
Growth factor receptor-bound protein 2
Ribosomal protein S6 kinase beta-1
FOXO
BCR-ABL/CRK/CRKL/CBL/PI3K complex
CHEBI:78543
ChEBI
P04637
UniProt
Crk-like protein
Cellular tumor antigen p53
Tyrosine-protein kinase JAK2
Signal transducer and activator of transcription 5A
Q07889
UniProt
Myc proto-oncogene protein
Myc proto-oncogene protein
Growth factor receptor-bound protein 2
P27986
UniProt
GO:0005634
GENE ONTOLOGY
Son of sevenless homolog 1
Son of sevenless homolog 1
Adapter molecule crk
BCR-ABL/GRB2/GAB2/SOS1 complex
Bcr-abl1 fusion protein
Bcr-abl1 fusion protein
Phosphatidylinositol 3-kinase regulatory subunit alpha
Nucleus
Cellular tumor antigen p53
E3 ubiquitin-protein ligase Mdm2
Multidrug resistance protein 1
FOXO
Signal transducer and activator of transcription 5A
Ponatinib Inhibition of BCR-ABL New
Tyrosine-protein kinase JAK2
P08183
UniProt
GO:0005737
GENE ONTOLOGY
P42345
UniProt
P23443
UniProt
Crk-like protein
P42229
UniProt
Serine/threonine-protein kinase mTOR
Cyclin-dependent kinase inhibitor 1B