GNG2
GNB1
PLCB1
ITPR1
PRKCB
NFKB1
GNG2
HRH1
GNAQ
GNAQ
HRH1
GNB1
Hsm
Inotp
Ca+
Chlopra
Ca+
H2O
Ca2+
Ca2+
GDP
GTP
Hsm
1,2DSG
P45B
↑ Pro-inflammatory
Cytokines, Cell Adhesion
Molecules, Chemotactic
Factors
M C R H
Endoplasmic Reticulum
Nucleus
Calcium Ion Channel
Cell Membrane
Cytoplasm
↑ Antigen Presentation
↑ Mediator Release
↓ Mast Cell Stabilization
The GPCR activates the G
protein by exchanging GDP
for GTP. This exchange
triggers the dissociation of
the Gα subunit from the Gβγ
dimer and the receptor.
Blocking the action of
histamine at the H1 receptor
helps to relieve allergic
reactions.