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Zinc GTPase HRas Ral guanine nucleotide dissociation stimulator RAS like proto-oncogene A RalA-binding protein 1 Cell division control protein 42 homolog Ras-related C3 botulinum toxin substrate 1 RAC-alpha serine/threonine- protein kinase Guanine nucleotide exchange factor VAV3 Bcl2-associated agonist of cell death Caspase-9 Forkhead box protein O4 Inhibitor of nuclear factor kappa-B kinase subunit alpha Bcl-2-like protein 1 Transforming protein RhoA Phospholipase D1 Ras-related C3 botulinum toxin substrate 1 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 ETS domain- containing protein Elk-1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC Phosphatidic Acid ERK 1/2 pathway Caspase Cascade Pathway AKT Pathway Anti-apoptotic Apoptosis Fas ligand expression Expression of anti-apoptotic genes Rac GDP-GTP exchange factors (eg. Vav and Sos1 Cytoplasm
HRAS RALGDS RALA RALBP1 CDC42 RAC1 AKT1 VAV3 BAD CASP9 FOXO4 CHUK BCL2L1 RHOA PLD1 RAC1 RAF1 MAP2K1 MAPK3 ELK1 Phosphate Phosphate Phosphate PI3K PIP3 NF-κB PIP2 PC Phosphatidic Acid ERK 1/2 pathway Caspase Cascade Pathway
Zinc HRAS RALGDS RALA RALBP1 CDC42 RAC1 AKT1 VAV3 BAD CASP9 FOXO4 CHUK BCL2L1 RHOA PLD1 RAC1 RAF1 MAP2K1 MAPK3 ELK1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC PA ER 1/ p Ca Ca P AKT Pathway Anti-apoptotic Apoptosis Fas ligand expression Expression of anti-apoptotic genes Rac GDP-GTP exchange factors (eg. Vav and Sos1 Cytoplasm
HRAS RALGDS RALA RALBP1 CDC42 RAC1 AKT1 VAV3 BAD CASP9 FOXO4 CHUK BCL2L1 RHOA PLD1 RAC1 RAF1 MAP2K1 MAPK3 ELK1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC PA ER 1/ p Ca Ca P