64931PathwayClassical Complement PathwayThe classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.
ProteinPW065057CenterPathwayVisualizationContext6533319642746#000099PathwayVisualization6481364931Classical Complement PathwayThe classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.
Protein1230782https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=11764931Pathway230783https://cgap.nci.nih.gov/Pathways/BioCarta/h_classicPathway64931Pathway1CellCL:00000002Platelet CL:00002335HepatocyteCL:00001823NeuronCL:00005404Cardiomyocyte CL:00007468Beta cellCL:00006391Homo sapiens9606EukaryoteHuman3Escherichia coli562Prokaryote12Mus musculus10090EukaryoteMouse24Solanum lycopersicum4081EukaryoteTomato4Arabidopsis thaliana3702EukaryoteThale cress18Saccharomyces cerevisiae4932EukaryoteYeast21Xenopus laevis8355EukaryoteAfrican clawed frog6Caenorhabditis elegans6239EukaryoteRoundworm49Bathymodiolus platifrons220390EukaryoteDeep sea mussel60Nitzschia sp.0001EukaryoteNitzschia42Bacteria2ProkaryoteBacteria17Rattus norvegicus10116EukaryoteRat5Bos taurus9913EukaryoteCattle10Drosophila melanogaster7227EukaryoteFruit fly5CytoplasmGO:00057373Mitochondrial MatrixGO:00057591CytosolGO:00058294PeroxisomeGO:000577713Endoplasmic ReticulumGO:000578314Mitochondrial Outer MembraneGO:00057412MitochondrionGO:00057397Endoplasmic Reticulum MembraneGO:000578925Golgi apparatusGO:000579410Cell MembraneGO:000588627Peroxisome MembraneGO:000577815NucleusGO:000563426Golgi apparatus membraneGO:000013935ChloroplastGO:000950711Extracellular SpaceGO:000561512Mitochondrial Inner MembraneGO:000574319sarcoplasmic reticulumGO:001652924Mitochondrial Intermembrane SpaceGO:00057586LysosomeGO:000576416Lysosomal LumenGO:004320236MembraneGO:00160208Blood VesselBTO:000110274112Endothelium BTO:00003931LiverBTO:00007597297Nervous SystemBTO:00014845cardiocyteBTO:000153918PancreasBTO:00009885181PW_BS0000518511PW_BS0000084311PW_BS00000416212PW_BS0000162111PW_BS000002261115PW_BS0000265411PW_BS000005181311PW_BS000018221411PW_BS000022397113PW_BS0000393211PW_BS000003215114PW_BS00002146114PW_BS00004649711PW_BS000049432511PW_BS00004314101PW_BS000014101711PW_BS000010592711PW_BS000059231511PW_BS00002329111PW_BS000029711PW_BS000007311511PW_BS000031918511PW_BS000091541315PW_BS000054562611PW_BS0000561041431PW_BS0001041115121PW_BS0001111122121PW_BS000112103331PW_BS0001031471241PW_BS000147151141PW_BS0001511553241PW_BS0001551613181PW_BS00016116611PW_BS0001661783211PW_BS0001781644PW_BS0001641601181PW_BS00016019914181PW_BS000024205561PW_BS000024206261PW_BS0000242137181PW_BS0000242111018PW_BS00002421425181PW_BS0000242164181PW_BS0000241985181PW_BS000024222341PW_BS0000241321121PW_BS00013221013181PW_BS0000242253541PW_BS0000242491341PW_BS0000242881441PW_BS000024226441PW_BS0000242905491PW_BS0000242851041PW_BS0000243081011PW_BS0000241333121PW_BS00013332914121PW_BS0000283361121PW_BS0000283344121PW_BS00002833527121PW_BS0000281151012PW_BS0001153317121PW_BS00002835625121PW_BS00002813013121PW_BS0001303683601PW_BS000028184121PW_BS000024372102PW_BS0000281181171PW_BS0001181355171PW_BS00013515111PW_BS000015253541PW_BS000024383751PW_BS00010027151PW_BS0000272231241PW_BS000024390761PW_BS0001123987171PW_BS000113406351PW_BS000115122551PW_BS0001223821451PW_BS000100407251PW_BS000115408451PW_BS000115124151PW_BS000124429151PW_BS0001154192551PW_BS0001151251351PW_BS000125405105PW_BS0001154222751PW_BS0001151203171PW_BS00012039914171PW_BS0001131192171PW_BS0001193744171PW_BS0000534641171PW_BS00011545525171PW_BS00011513613171PW_BS0001363761017PW_BS00005337527171PW_BS0000532975101PW_BS00002448414101PW_BS0001154793101PW_BS0001154812101PW_BS0001154824101PW_BS0001152991101PW_BS0000244957101PW_BS00011549025101PW_BS0001154781010PW_BS00011549127101PW_BS00011530013101PW_BS0000243891461PW_BS000112501361PW_BS000115502461PW_BS000115388161PW_BS0001125072561PW_BS000115209106PW_BS0000245082761PW_BS0001153951361PW_BS0001133551914PW_BS000035471914PW_BS000047422411PW_BS0000425811411PW_BS000058171211PW_BS0000179611PW_BS000009711113PW_BS00007172513PW_BS0000726618518PW_BS0000662811611PW_BS000028101531PW_BS0001011901118PW_BS00002411PW_BS00000134524121PW_BS0000281141112PW_BS0001147413PW_BS000074228361PW_BS0000244182451PW_BS000115409115PW_BS00011545424171PW_BS0001151371117PW_BS00013748924101PW_BS0001155062461PW_BS00011584PW_B0000842137888ProteinComplex12147804ProteinComplex1819525185PW_B0000852157806ProteinComplex12167889ProteinComplex1819955186PW_B0000862177894ProteinComplex12187893ProteinComplex18208751423MagnesiumHMDB0000547Magnesium salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. Physiologically, it exists as an ion in the body. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilatation, convulsions, tremors, depression, and psychotic behavior. Magnesium ion in large amounts is an ionic laxative, and magnesium sulfate (Epsom salts) is sometimes used for this purpose. So-called "milk of magnesia" is a water suspension of one of the few insoluble magnesium compounds, magnesium hydroxide; the undissolved particles give rise to its appearance and name. Milk of magnesia is a mild base, and is commonly used as an antacid.22537-22-0C003058881842013-HYDROXY-MAGNESIUM-PROTOPORP865DB01378[Mg++]MgInChI=1S/Mg/q+2JLVVSXFLKOJNIY-UHFFFAOYSA-Nmagnesium(2+) ion24.30523.9850418980magnesium(2+) ion22FDB003518Magnesium;Magnesium ions;Magnesium ion;Magnesium, doubly charged positive ion;Magnesium, ion (mg(2+));Mg(2+);Mg2+PW_C000423Mg2+86822742681647627272681158191888322936399833992211167461483491529431764142124102411592942233126293373745403147749148695449745652531045329111535611253761035906147593415160381556094161625016664841786594164688116069791997170205719420672272137233211725021473102167313198747322211763132118432101231222512324249125132881258122612729290152752851533730877137133772363297793733678393334784173357848911578522331785363567857413080020368800451848004837280623118806541358086515809652538184151938323839490027108596223110559390115687398119974406120070122120247382120702407120981408121181124121265429121319419121924125122086405122408422122759120122921399123307119123546374123835464123889455124477136124637376124978375125447297125598484125669479125777481125921482125947299125973495126000490126243478126553491126753300127125389127164501127380502127407388127451507127804209128125508128347395353CalciumHMDB0000464Calcium is essential for the normal growth and maintenance of bones and teeth, and calcium requirements must be met throughout life. Requirements are greatest during periods of growth, such as childhood, during pregnancy and when breast-feeding. Long-term calcium deficiency can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. Adults need between 1,000 and 1,300 mg of calcium in their daily diet. Calcium is essential for living organisms, particularly in cell physiology, and is the most common metal in many animals. Physiologically, it exists as an ion in the body. Calcium combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Calcium is an important component of a healthy diet. A deficit can affect bone and tooth formation, while overretention can cause kidney stones. Vitamin D is needed to absorb calcium. Dairy products, such as milk and cheese, are a well-known source of calcium. However, some individuals are allergic to dairy products and even more people, particularly those of non-European descent, are lactose-intolerant, leaving them unable to consume dairy products. Fortunately, many other good sources of calcium exist. These include: seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); beans; amaranth; collard greens; okra; rutabaga; broccoli; kale; and fortified products such as orange juice and soy milk. Calcium has also been found to assist in the production of lymphatic fluids.14127-61-8C0007627129108CA%2b2266DB01373[Ca++]CaInChI=1S/Ca/q+2BHPQYMZQTOCNFJ-UHFFFAOYSA-Ncalcium(2+) ion40.07839.9625911550calcium(2+) ion22FDB003513Ca;Calcium element;Ca(2+);Ca2+;Calcium ion;Calcium, doubly charged positive ionPW_C000353Ca2+27616303855314601294115993219973510463116346116447147849149142155243211658213817279618293793159713160723942294186664782104822285340111578010171792057232211725816072811901177421311837198118422101219816412215285152881511535030869336177389331776001157815413278266356785263457872413078908114804137480589228818265112022012212046540512104912412130041812137741912185038312192312512237040912289513512309937612361311812387045412393645512440339812447613612492413712557129712571147812598148912600929912605049012653349512720320912743450612746038812750250712810539014646Complement C4-BP0C0L5
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
C4B1807801818335114647Complement C4-AP0C0L4
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
C4A1807811818345114667Complement C2P06681
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
C213.4.21.43808341818355114666Complement C2-AP06681
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
C213.4.21.43808311818465114658Complement C2-BP06681
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
C213.4.21.43808121818475114584Complement C3P01024
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
C318057818085415818845114583Complement C3aP01024
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
C318057718086715818855114582Complement C3bP01024
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
C318057518086615818865114650Complement C5P01031
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
C518079518087215819165114649Complement C5aP01031
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
C518079318087315819175114651Complement C5bP01031
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
C5180797180875158087714819185114653Complement component C6P13671
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
C6180802180874158087814819545114654Complement component C7P10643
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
C7180804180876158087914819725114655Complement component C8 alpha chainP07357
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
C8A180806180880148088115819715114652Complement component C9P02748
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934).
C918080018088214808831582003512701Complement C1r subcomponentP00736C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement systemHMDBP07480C1R12p13AC14007713.4.21.4180785182074512702Complement C1s subcomponent precursorP09871C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4HMDBP07481C1S12p13AB00907613.4.21.4280784182075512700Complement C1q subcomponent subunit CP02747C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexesHMDBP07479C1QC1p36.11AK057792180788182089512699Complement C1q subcomponent subunit BP02746C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexesHMDBP07478C1QB1p36.12M36278180787182090512698Complement C1q subcomponent subunit AP02745C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexesHMDBP07477C1QA1p36.12AF135157180786182091517888C2a,C3b,C4b,C5b convertase1PW_P007888159721466615973145821597414646159751465181932517804Complement component C61PW_P00780415833146538080317806Complement component C8 1PW_P00780615835146558080717889C5,C6,C7 convertase1PW_P00788915976146501597714653159781465481969517894Complement C1q1PW_P00789415984270015985269915986269882083517893C1r,C1s Complex1PW_P00789315982270115983270282073517795Complement C41PW_P007795158191464615820146478078217797Complement C4-B1PW_P00779715826146468078917798Complement component 4A 1PW_P00779815827146478079017886Complement C2 with Mg++1PW_P007886159681466781042381840517819Complement C2-A1PW_P00781915862146668083517818Complement C2-B1PW_P00781815861146588083317809C3C5 convertase (2)1PW_P007809158431464615844146668081317734Complement C31PW_P00773415719145848057617736Complement C3a1PW_P00773615721145838058017735Complement C3b1PW_P00773515720145828057917887C2a,C3b,C4b Convertase1PW_P00788715969146661597014582159711464681909517800Complement C51PW_P00780015829146508079417801Complement C5a1PW_P00780115830146498079617802Complement C5b1PW_P00780215831146518079817805Complement component C71PW_P00780515834146548080517803Complement component C91PW_P00780315832146528080117807MAC (Membrane Attack Complex)1PW_P007807158361465315837146541583814655158391465215840146518080817891Complement C1r subcomponent1PW_P00789115980270182062517892Complement C1s 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