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Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 6 FAS-associated factor 1 FAS-associated death domain protein Caspase-10 Death domain- associated protein 6 Receptor- interacting serine/threonine- protein kinase 2 FAS-associated death domain protein Pro-Caspase-8 Caspase-8 Tyrosine- protein phosphatase non-receptor type 13 FAS-associated factor 1 Caspase-3 Caspase-6 Lamin-B1 Lamin-B2 Prelamin-A/C Rho GDP- dissociation inhibitor 2 DNA fragmentation factor subunit alpha DNA fragmentation factor subunit beta Spectrin alpha chain, non- erythrocytic 1 DNA-dependent protein kinase catalytic subunit Retinoblastoma- associated protein Poly [ADP-ribose] polymerase 1 Serine/threonine- protein kinase PAK 1 Serine/threonine- protein kinase PAK 2 Caspase-7 Caspase-10 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 4 Death domain- associated protein 6 Mitogen- activated protein kinase kinase kinase 7 Mitogen- activated protein kinase 8 Transcription factor AP-1 DNA fragmentation factor subunit beta Pi Pi Pi CASP8 and FADD-like apoptosis regulator Pi cleavage cleavage cleavage cleavage Ceramide DNA Fragmentation Nucleus Extracellular Cytoplasm of Target Cell . Fas ligand on cytotoxic T lymphocytes
Nucleus FASLG FAS FAF1 FADD CASP10 DAXX RIPK2 FADD CASP8 CASP8 PTPN13 FAF1 Unknown CASP6 LMNB1 LMNB2 LMNA ARHGDIB DFFA DFFB SPTAN1 PRKDC RB1 PARP1 PAK1 PAK2 CASP7 CASP10 MAP3K1 MAP2K4 DAXX MAP3K7 MAPK8 JUN DFFB Phosphate Phosphate Phosphate CFLAR Phosphate
FASLG FAS FAF1 FADD CASP10 DAXX RIPK2 FADD CASP8 CASP8 PTPN13 FAF1 CASP6 LMNB1 LMNB2 LMNA ARHGDIB DFFA DFFB SPTAN1 PRKDC RB1 PARP1 PAK1 PAK2 CASP7 CASP10 MAP3K1 MAP2K4 DAXX MAP3K7 MAPK8 JUN DFFB Pi Pi Pi CFLAR Pi cleavage cleavage cleavage cleavage Ceramide DNA Fragmentation Nucleus Extracellular Cytoplasm of Target Cell . Fas ligand on cytotoxic T lymphocytes
Nucleus FASLG FAS FAF1 FADD CASP10 DAXX RIPK2 FADD CASP8 CASP8 PTPN13 FAF1 CASP6 LMNB1 LMNB2 LMNA ARHGDIB DFFA DFFB SPTAN1 PRKDC RB1 PARP1 PAK1 PAK2 CASP7 CASP10 MAP3K1 MAP2K4 DAXX MAP3K7 MAPK8 JUN DFFB Pi Pi Pi CFLAR Pi