DIACYLGLYCEROL
BioCyc
Q9BXA5
UniProt
Interaction973
Succinate receptor 1 activates Phospholipase C, beta 1
C01243
KEGG Compound
127983
ChemSpider
Interaction975
Calcium activates Mitogen-activated protein kinase 11
Interaction974
Inositol 1,3,4-trisphosphate activates Calcium
5280360
PubChem-compound
Interaction977
Nitric-oxide synthase, endothelial activates Nitric oxide
Interaction976
Calcium activates Nitric-oxide synthase, endothelial
C20H32O5
Prostaglandin E2
352.22498
Interaction979
Protein kinase C activates ERK1, ERK2
P28482
UniProt
Interaction978
DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) activates Protein kinase C
HMDB0000254
HMDB
direct_interaction
3.1.4.11
false
3.1.4.11
PIP2(18:1(11Z)/20:3(8Z,11Z,14Z)) → DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0) + Inositol 1,3,4-trisphosphate
LEFT_TO_RIGHT
SMILES
OC(=O)CCC(O)=O
Nitric-oxide synthase, endothelial
Calcium
Inhibitor of nuclear factor kappa-B kinase
DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0)
Nitric oxide
CHEBI:77096
ChEBI
SMILES
[H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
1.0
53480273
PubChem-compound
HMDB0001220
HMDB
Inhibitor of nuclear factor kappa-B kinase subunit beta
Interaction980
ERK1, ERK2 activates COX1 homodimer complex
Interaction982
Protein kinase C activates Inhibitor of nuclear factor kappa-B kinase
Interaction981
COX1 homodimer complex activates Prostaglandin E2
1.0
C00165
KEGG Compound
Interaction983
Mitogen-activated protein kinase 11 activates Cyclic AMP-responsive element-binding protein 1
ReactionCatalysis133147
ACTIVATION
1.0
C00042
KEGG Compound
1078
ChemSpider
NITRIC-OXIDE
BioCyc
Q9Y6K9
UniProt
1.0
HMDB0003378
HMDB
Cytoplasm
P29474
UniProt
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Nitric oxide synthase, endothelial
Mitogen-activated protein kinase 11
Homo sapiens
Succinate receptor 1
INOSITOL-1-3-4-TRIPHOSPHATE
BioCyc
439455
PubChem-compound
PW085652
PathWhiz
Q9NQ66
UniProt
C6H15O15P3
Inositol 1,3,4-trisphosphate
419.96237
Succinate Signalling During Inflammation
ERK1, ERK2
Protein kinase C alpha type
HMDB0010082
HMDB
Succinate receptor 1
C00626
KEGG Compound
CHEBI:16480
ChEBI
C00584
KEGG Compound
P19838
UniProt
Nuclear factor NF-kappa-B p105 subunit
Prostaglandin G/H synthase 1
Inhibitor of nuclear factor kappa-B kinase subunit beta
NO
Nitric oxide
29.997988
Mitogen-activated protein kinase 3
CHEBI:15551
ChEBI
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
363-24-6
CAS
C47H85O19P3
PIP2(18:1(11Z)/20:3(8Z,11Z,14Z))
1046.4897
9543736
PubChem-compound
266
ChemSpider
Reaction143078
false
Inhibitor of nuclear factor kappa-B kinase subunit beta + Nuclear factor NF-kappa-B p105 subunit → Nuclear factor NF-kappa-B p105 subunit
LEFT_TO_RIGHT
Mitogen-activated protein kinase 1
Inhibitor of nuclear factor kappa-B kinase subunit alpha
P17252
UniProt
HMDB0007112
HMDB
9606
TAXONOMY
Mitogen-activated protein kinase 1
Transport6542
false
Nuclear factor NF-kappa-B p105 subunit (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Nucleus
LEFT_TO_RIGHT
145068
PubChem-compound
C00076
KEGG Compound
Prostaglandin E2
SUC
BioCyc
110-15-6
CAS
CA%2b2
BioCyc
2.0
Succinate receptor 1
SMILES
O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O
GO:0005886
GENE ONTOLOGY
5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
BioCyc
PIP2(18:1(11Z)/20:3(8Z,11Z,14Z))
Ca
Calcium
39.96259
Mitogen-activated protein kinase 11
HMDB0001143
HMDB
Cell Membrane
Cyclic AMP-responsive element-binding protein 1
Phosphatidylinositols
BioCyc
Mitogen-activated protein kinase 11
SMILES
[N]=O
O15111
UniProt
ReactionCatalysis130870
ACTIVATION
Prostaglandin G/H synthase 1
271
PubChem-compound
Nuclear factor NF-kappa-B p105 subunit
388561
ChemSpider
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Succinic acid
HMDB0000464
HMDB
P16220
UniProt
Nitric oxide synthase, endothelial
NF-kappa-B essential modulator
Nuclear factor NF-kappa-B p105 subunit
GO:0005634
GENE ONTOLOGY
SMILES
CCCCCC\C=C/CCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC
CHEBI:15741
ChEBI
4444059
ChemSpider
C00533
KEGG Compound
1110
PubChem-compound
P23219
UniProt
10102-43-9
CAS
1.0
Cyclic AMP-responsive element-binding protein 1
14127-61-8
CAS
SMILES
[Ca++]
Protein kinase C alpha type
Inhibitor of nuclear factor kappa-B kinase subunit alpha
7822686
ChemSpider
Q15759
UniProt
NF-kappa-B essential modulator
C4H6O4
Succinic acid
118.02661
C39H68O5
DG(16:0/20:4(5Z,8Z,11Z,14Z)/0:0)
616.50665
Nucleus
24767959
ChemSpider
98102-63-7
CAS
CHEBI:18228
ChEBI
1.0
Inositol 1,3,4-trisphosphate
Interaction964
Succinic acid activates Succinate receptor 1
P27361
UniProt
Mitogen-activated protein kinase 3
GO:0005737
GENE ONTOLOGY
CHEBI:29108
ChEBI
O14920
UniProt
SMP0084634
SMPDB