101268
Pathway
Protein Synthesis: Alanine
Protein synthesis is an essential life process that builds the important large amino acid macromolecules that function as enzymes, antibodies, and cellular structural components. Although synthesis begins with the transcription of DNA into RNA, this pathway depicts the reactions that occur during translation. Transcribed messenger RNA (mRNA), which contains the genetic code to direct protein synthesis, is transported out of the nucleus and becomes bound to ribosomes in the cytoplasm or endoplasmic reticulum. The amino acids required to assemble polypeptide chains are delivered to the ribosomes using transfer RNA (tRNA). Each tRNA molecule has both a binding site for a specific amino acid and a three-nucleotide sequence called the anticodon that forms three complementary base pairs with an mRNA codon. Charging or loading the appropriate amino acid onto its tRNA is carried out by an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. This enzyme catalyzes the esterification of an amino acid to one of all its compatible tRNAs to form an aminoacyl-tRNA. Each of the twenty amino acids has a corresponding aa-tRNA made by a specific aminoacyl-tRNA synthetase. Ribosomes match the anticodons of the charged tRNA molecules with successive codons of the mRNA. After a match is found, the ribosome transfers the amino acid from the matching tRNA onto the growing peptide chain via a reaction termed peptide condensation, and the tRNAs, no longer carrying amino acids, are released.
Protein
PW101384
Center
PathwayVisualizationContext101660
1080
1600
#000099
PathwayVisualization101140
101268
Protein Synthesis: Alanine
Protein synthesis is an essential life process that builds the important large amino acid macromolecules that function as enzymes, antibodies, and cellular structural components. Although synthesis begins with the transcription of DNA into RNA, this pathway depicts the reactions that occur during translation. Transcribed messenger RNA (mRNA), which contains the genetic code to direct protein synthesis, is transported out of the nucleus and becomes bound to ribosomes in the cytoplasm or endoplasmic reticulum. The amino acids required to assemble polypeptide chains are delivered to the ribosomes using transfer RNA (tRNA). Each tRNA molecule has both a binding site for a specific amino acid and a three-nucleotide sequence called the anticodon that forms three complementary base pairs with an mRNA codon. Charging or loading the appropriate amino acid onto its tRNA is carried out by an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. This enzyme catalyzes the esterification of an amino acid to one of all its compatible tRNAs to form an aminoacyl-tRNA. Each of the twenty amino acids has a corresponding aa-tRNA made by a specific aminoacyl-tRNA synthetase. Ribosomes match the anticodons of the charged tRNA molecules with successive codons of the mRNA. After a match is found, the ribosome transfers the amino acid from the matching tRNA onto the growing peptide chain via a reaction termed peptide condensation, and the tRNAs, no longer carrying amino acids, are released.
Protein
1
94226
3
SubPathway
92420
105
Compound
8
270611
27911835
Sun L, Song Y, Blocquel D, Yang XL, Schimmel P: Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14300-14305. doi: 10.1073/pnas.1617316113. Epub 2016 Nov 28.
101268
Pathway
277826
12962325
Odintsova TI, Muller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J Protein Chem. 2003 Apr;22(3):249-58.
101268
Pathway
277827
8706699
Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur J Biochem. 1996 Jul 1;239(1):144-9.
101268
Pathway
1
Cell
CL:0000000
2
Platelet
CL:0000233
5
Hepatocyte
CL:0000182
3
Neuron
CL:0000540
4
Cardiomyocyte
CL:0000746
8
Beta cell
CL:0000639
7
Epithelial Cell
CL:0000066
6
Myocyte
CL:0000187
1
Homo sapiens
9606
Eukaryote
Human
2
Bacteria
2
Prokaryote
Bacteria
3
Escherichia coli
562
Prokaryote
12
Mus musculus
10090
Eukaryote
Mouse
17
Rattus norvegicus
10116
Eukaryote
Rat
19
Schizosaccharomyces pombe
4896
Eukaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
25
Escherichia coli (strain K12)
83333
Prokaryote
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
23
Pseudomonas aeruginosa
287
Prokaryote
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
5
Bos taurus
9913
Eukaryote
Cattle
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
51
Picea sitchensis
3332
Eukaryote
Sitka spruce
7
Chlamydomonas reinhardtii
3055
Eukaryote
62
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
62977
Prokaryote
1
Cytosol
GO:0005829
3
Mitochondrial Matrix
GO:0005759
5
Cytoplasm
GO:0005737
14
Mitochondrial Outer Membrane
GO:0005741
2
Mitochondrion
GO:0005739
15
Nucleus
GO:0005634
4
Peroxisome
GO:0005777
13
Endoplasmic Reticulum
GO:0005783
7
Endoplasmic Reticulum Membrane
GO:0005789
10
Cell Membrane
GO:0005886
27
Peroxisome Membrane
GO:0005778
31
Periplasmic Space
GO:0005620
11
Extracellular Space
GO:0005615
35
Chloroplast
GO:0009507
12
Mitochondrial Inner Membrane
GO:0005743
32
Inner Membrane
GO:0070258
48
Cell cortex
GO:0005938
2
Endothelium
BTO:0000393
1
Liver
BTO:0000759
72
9
7
Nervous System
BTO:0001484
18
Pancreas
BTO:0000988
25
Intestine
BTO:0000648
8
Blood Vessel
BTO:0001102
74
11
9
Muscle
BTO:0000887
141
18
24
Brain
BTO:0000142
89
16
28
Stomach
BTO:0001307
155
26
22
Bladder
BTO:0000123
2
1
1
1
PW_BS000002
4
3
1
1
PW_BS000004
8
5
1
1
PW_BS000008
16
2
1
2
PW_BS000016
22
14
1
1
PW_BS000022
13
1
2
1
PW_BS000013
32
1
15
1
5
PW_BS000032
5
4
1
1
PW_BS000005
39
7
1
1
3
PW_BS000039
3
2
1
1
PW_BS000003
18
13
1
1
PW_BS000018
10
1
7
1
1
PW_BS000010
49
7
1
1
PW_BS000049
14
10
1
PW_BS000014
58
1
14
1
1
PW_BS000058
59
27
1
1
PW_BS000059
27
15
1
PW_BS000027
46
1
1
4
PW_BS000046
29
1
1
1
PW_BS000029
66
18
5
1
8
PW_BS000066
72
5
1
3
PW_BS000072
61
25
1
7
PW_BS000061
51
8
1
PW_BS000051
23
15
1
1
PW_BS000023
31
1
5
1
1
PW_BS000031
91
8
5
1
1
PW_BS000091
54
1
3
1
5
PW_BS000054
89
2
PW_BS000089
26
1
1
1
5
PW_BS000026
7
1
1
PW_BS000007
97
1
5
2
1
PW_BS000097
100
5
2
1
PW_BS000100
104
14
3
1
PW_BS000104
101
5
3
1
PW_BS000101
111
5
12
1
PW_BS000111
112
2
12
1
PW_BS000112
103
3
3
1
PW_BS000103
117
1
3
1
PW_BS000117
118
1
17
1
PW_BS000118
120
3
17
1
PW_BS000120
129
1
5
12
1
PW_BS000129
132
1
12
1
PW_BS000132
133
3
12
1
PW_BS000133
135
5
17
1
PW_BS000135
108
1
3
PW_BS000108
143
1
5
19
1
PW_BS000143
146
5
19
1
PW_BS000146
107
31
3
PW_BS000107
147
1
24
1
PW_BS000147
151
1
4
1
PW_BS000151
155
3
24
1
PW_BS000155
161
3
18
1
PW_BS000161
166
1
1
PW_BS000166
178
3
21
1
PW_BS000178
188
1
18
PW_BS000024
160
1
18
1
PW_BS000160
199
14
18
1
PW_BS000024
205
5
6
1
PW_BS000024
206
2
6
1
PW_BS000024
210
13
18
1
PW_BS000024
213
7
18
1
PW_BS000024
211
10
18
PW_BS000024
198
5
18
1
PW_BS000024
216
4
18
1
PW_BS000024
217
15
18
PW_BS000024
218
15
18
1
PW_BS000024
163
2
18
1
PW_BS000163
222
3
4
1
PW_BS000024
190
11
18
PW_BS000024
225
35
4
1
PW_BS000024
277
1
2
18
PW_BS000024
170
18
PW_BS000170
281
1
25
1
PW_BS000024
164
4
PW_BS000164
285
10
4
1
PW_BS000024
226
4
4
1
PW_BS000024
290
5
49
1
PW_BS000024
223
12
4
1
PW_BS000024
308
10
1
1
PW_BS000024
315
1
23
PW_BS000024
322
1
23
1
PW_BS000024
318
31
23
PW_BS000024
253
5
4
1
PW_BS000024
134
12
12
1
PW_BS000134
329
14
12
1
PW_BS000028
333
1
2
12
PW_BS000028
336
1
12
1
PW_BS000028
332
1
7
12
1
PW_BS000028
350
1
14
12
1
PW_BS000028
128
15
12
1
PW_BS000128
351
15
12
PW_BS000028
353
25
12
7
PW_BS000028
335
27
12
1
PW_BS000028
115
10
12
PW_BS000115
130
13
12
1
PW_BS000130
331
7
12
1
PW_BS000028
334
4
12
1
PW_BS000028
368
3
60
1
PW_BS000028
184
1
2
1
PW_BS000024
119
2
17
1
PW_BS000119
1
1
PW_BS000001
124
1
5
1
PW_BS000124
94
3
PW_BS000094
388
1
6
1
PW_BS000112
109
32
3
PW_BS000109
122
5
5
1
PW_BS000122
406
3
5
1
PW_BS000115
407
2
5
1
PW_BS000115
382
14
5
1
PW_BS000100
412
1
2
5
PW_BS000115
429
1
5
1
PW_BS000115
123
1
7
5
1
PW_BS000123
433
1
14
5
1
PW_BS000115
408
4
5
1
PW_BS000115
410
15
5
1
PW_BS000115
125
13
5
1
PW_BS000125
383
7
5
1
PW_BS000100
405
10
5
PW_BS000115
422
27
5
1
PW_BS000115
435
15
5
PW_BS000115
399
14
17
1
PW_BS000113
446
1
2
17
PW_BS000115
464
1
17
1
PW_BS000115
447
1
7
17
1
PW_BS000115
468
1
14
17
1
PW_BS000115
374
4
17
1
PW_BS000053
444
15
17
1
PW_BS000115
136
13
17
1
PW_BS000136
398
7
17
1
PW_BS000113
376
10
17
PW_BS000053
472
25
17
7
PW_BS000115
375
27
17
1
PW_BS000053
470
15
17
PW_BS000115
297
5
10
1
PW_BS000024
479
3
10
1
PW_BS000115
299
1
10
1
PW_BS000024
481
2
10
1
PW_BS000115
484
14
10
1
PW_BS000115
485
15
10
1
PW_BS000115
300
13
10
1
PW_BS000024
495
7
10
1
PW_BS000115
478
10
10
PW_BS000115
491
27
10
1
PW_BS000115
499
15
10
PW_BS000115
501
3
6
1
PW_BS000115
389
14
6
1
PW_BS000112
516
15
6
1
PW_BS000115
395
13
6
1
PW_BS000113
390
7
6
1
PW_BS000112
209
10
6
PW_BS000024
508
27
6
1
PW_BS000115
517
15
6
PW_BS000115
50
9
5
1
6
PW_BS000050
15
11
1
PW_BS000015
105
11
3
PW_BS000105
85
24
10
1
1
PW_BS000085
320
11
23
PW_BS000024
346
9
5
12
6
PW_BS000028
327
1
1
12
5
PW_BS000028
326
8
12
PW_BS000028
114
11
12
PW_BS000114
423
9
5
5
6
PW_BS000115
424
1
1
5
5
PW_BS000115
416
8
5
PW_BS000115
409
11
5
PW_BS000115
458
9
5
17
6
PW_BS000115
459
1
1
17
5
PW_BS000115
452
8
17
PW_BS000115
137
11
17
PW_BS000137
502
4
6
1
PW_BS000115
249
13
4
1
PW_BS000024
288
14
4
1
PW_BS000024
306
35
51
1
PW_BS000024
17
12
1
1
PW_BS000017
372
10
2
PW_BS000028
384
12
5
1
PW_BS000100
391
12
6
1
PW_BS000112
121
12
17
1
PW_BS000121
68
2
5
1
2
PW_BS000068
70
28
5
1
1
PW_BS000070
483
11
10
PW_BS000115
208
11
6
PW_BS000024
278
22
48
7
1
PW_BS000024
651
10
62
4
PW_BS000508
222
PW_B000222
577
11001
ProteinComplex
1
578
11454
ProteinComplex
1
579
490
ElementCollection
1
223
PW_B000223
580
2
NucleicAcid
1
581
11001
ProteinComplex
1
582
11454
ProteinComplex
1
583
490
ElementCollection
1
414
Adenosine triphosphate
HMDB0000538
Adenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways. Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415, 15129319, 14707763, 14696970, 11157473).
56-65-5
C00002
5957
15422
ATP
5742
DB00171
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
C10H16N5O13P3
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
ZKHQWZAMYRWXGA-KQYNXXCUSA-N
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
507.181
506.995745159
-2.05
7
adenosine triphosphate
0
-3
FDB021813
5'-(tetrahydrogen triphosphate) adenosine;5'-atp;Atp;Adenosine 5'-triphosphate;Adenosine 5'-triphosphorate;Adenosine 5'-triphosphoric acid;Adenosine triphosphate;Adenylpyrophosphorate;Adenylpyrophosphoric acid;Adephos;Adetol;Adynol;Atipi;Atriphos;Cardenosine;Fosfobion;Glucobasin;Myotriphos;Phosphobion;Striadyne;Triadenyl;Triphosphaden;Triphosphoric acid adenosine ester;Adenosine-5'-triphosphate;H4atp;Adenosine triphosphoric acid;Adenosine-5'-triphosphoric acid
PW_C000414
ATP
9
2
21
4
60
8
266
16
414
22
478
13
733
32
799
5
934
39
976
3
2105
18
2112
10
2146
49
2156
14
2160
58
2405
59
2434
27
2726
46
2812
29
3029
66
3163
72
3616
61
3617
51
4399
23
4474
31
4768
91
4864
54
5032
89
5035
26
5155
7
5205
97
5215
100
5250
104
5291
101
5313
111
5346
112
5390
103
5406
117
5430
118
5443
120
5542
129
5556
132
5569
133
5603
135
5621
108
5846
143
5854
146
5876
107
5897
147
5924
151
6048
155
6109
161
6230
166
6493
178
6839
188
6870
160
6976
199
7157
205
7184
206
7209
210
7225
213
7229
211
7298
198
7302
216
7390
217
7408
218
7432
163
7481
222
7499
190
8186
225
11847
277
11903
170
12010
281
12039
164
12178
285
12578
226
12691
290
13264
223
15327
308
42326
315
42621
322
42694
318
77028
253
77218
134
77233
329
77468
333
77632
336
78037
332
78041
350
78168
128
78214
351
78240
353
78411
335
78494
115
78850
130
78865
331
78919
334
80028
368
80046
184
80674
119
85629
1
94826
124
113234
94
113282
388
116280
109
119914
122
119992
406
120154
407
120245
382
120362
412
121246
429
121392
123
121397
433
121471
408
121974
410
122065
125
122079
383
122083
405
122402
422
122444
435
122919
399
123009
446
123816
464
123951
447
123956
468
124029
374
124527
444
124616
136
124630
398
124634
376
124943
472
124972
375
125011
470
125304
297
125371
479
125392
299
125515
481
125595
484
126123
485
126220
300
126234
495
126240
478
126547
491
126596
499
126913
501
127123
389
127731
516
127781
395
127796
390
127801
209
128119
508
128167
517
105
L-Alanine
HMDB0000161
Alanine is a non-essential amino acid made in the body from either the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. This finding may relate to muscle metabolism. Alanine is highly concentrated in meat products and other high-protein foods like wheat germ and cottage cheese. Alanine is an important participant as well as a regulator of glucose metabolism. Alanine levels parallel blood sugar levels in both diabetes and hypoglycemia, and alanine reduces both severe hypoglycemia and the ketosis of diabetes. It is an important amino acid for lymphocyte reproduction and immunity. Alanine therapy has helped dissolve kidney stones in experimental animals. Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. Alanine, like GABA, taurine, and glycine, is an inhibitory neurotransmitter in the brain (http://www.dcnutrition.com/AminoAcids/). L-Alanine has been found to be associated with glucagon deficiency, which is an inborn error of metabolism.
56-41-7
C00041
5950
16977
L-ALPHA-ALANINE
5735
DB00160
C[C@H](N)C(O)=O
C3H7NO2
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
QNAYBMKLOCPYGJ-REOHCLBHSA-N
(2S)-2-aminopropanoic acid
89.0932
89.047678473
0.70
2
L-alanine
0
0
FDB000556
(2s)-2-aminopropanoate;(2s)-2-aminopropanoic acid;(s)-(+)-alanine;(s)-2-aminopropanoate;(s)-2-aminopropanoic acid;(s)-2-amino-propanoate;(s)-2-amino-propanoic acid;(s)-alanine;2-aminopropanoate;2-aminopropanoic acid;2-aminopropionate;2-aminopropionic acid;2-ammoniopropanoate;2-ammoniopropanoic acid;Ala;Alanine;L-(+)-alanine;L-2-aminopropanoate;L-2-aminopropanoic acid;L-2-aminopropionate;L-2-aminopropionic acid;L-a-alanine;L-a-aminopropionate;L-a-aminopropionic acid;L-alpha-alanine;L-alpha-aminopropionate;L-alpha-aminopropionic acid;A-alanine;A-aminopropionate;A-aminopropionic acid;Alpha-alanine;Alpha-aminopropanoate;Alpha-aminopropanoic acid;Alpha-aminopropionate;Alpha-aminopropionic acid;A;L-alanin;L-α-alanine
PW_C000105
Ala
10
2
29
4
316
8
1446
50
1453
51
1454
26
3022
15
3439
3
5407
117
5418
103
5431
118
5452
120
5557
132
5578
133
5637
107
5638
108
5883
105
6529
85
8350
225
12271
151
12620
31
12627
18
15230
222
42452
320
42453
318
42534
315
77969
346
77975
327
77988
326
78008
111
78092
112
79165
114
80693
135
119910
122
120015
124
120026
406
121145
423
121151
424
121164
416
121220
409
122139
407
123717
458
123723
459
123736
452
123790
137
124691
119
125300
297
125393
299
125404
479
126296
481
126850
205
126933
388
126944
501
127860
206
32
Adenosine monophosphate
HMDB0000045
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem 'sweeter'. This potentially makes lower calorie food products more palatable.
61-19-8
C00020
6083
16027
AMP
5858
DB00131
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
C10H14N5O7P
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
UDMBCSSLTHHNCD-KQYNXXCUSA-N
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
347.2212
347.063084339
-2.02
5
adenylate
0
-2
DBMET00485
FDB021806
5'-amp;5'-adenosine monophosphate;5'-adenylate;5'-adenylic acid;Amp;Adenosine 5'-monophosphate;Adenosine 5'-phosphate;Adenosine 5'-phosphorate;Adenosine 5'-phosphoric acid;Adenosine phosphate;Adenosine-5'-monophosphorate;Adenosine-5'-monophosphoric acid;Adenosine-5-monophosphorate;Adenosine-5-monophosphoric acid;Adenosine-monophosphate;Adenosine-phosphate;Adenovite;Adenylate;Adenylic acid;Cardiomone;Lycedan;Muscle adenylate;Muscle adenylic acid;My-b-den;My-beta-den;Phosaden;Phosphaden;Phosphentaside;5'-o-phosphonoadenosine;Adenosine 5'-(dihydrogen phosphate);Adenosine monophosphate;Adenosine-5'p;Adenosini phosphas;Ado5'p;Fosfato de adenosina;Pa;Pado;Phosphate d'adenosine;5'-adenosine monophosphoric acid;Adenosine phosphoric acid;Adenosine 5'-(dihydrogen phosphoric acid);Adenosine 5'-monophosphoric acid;Adenosine monophosphoric acid;Adenosine-5'-monophosphate;Phosphoric acid d'adenosine
PW_C000032
AMP
11
2
34
4
62
8
270
16
734
32
881
22
1189
14
4572
5
4867
54
5033
89
5251
104
5408
117
5423
103
5432
118
5457
120
5558
132
5583
133
5779
101
5795
108
6977
199
7072
188
11789
198
11868
161
11988
151
12003
222
12580
226
12636
31
12694
290
13331
225
42266
3
42646
315
77234
329
77325
111
78392
334
78809
115
79320
112
80399
1
80684
135
80900
7
119916
122
120016
124
120031
406
120246
382
120888
405
121954
408
122920
399
123464
376
124507
374
125306
297
125394
299
125409
479
125596
484
126853
205
126934
388
126949
501
127124
389
127311
209
127711
502
170
Pyrophosphate
HMDB0000250
The anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. The pyrophosphate anion is abbreviated PPi and is formed by the hydrolysis of ATP into AMP in cells. This hydrolysis is called pyrophosphorolysis. The pyrophosphate anion has the structure P2O74-, and is an acid anhydride of phosphate. It is unstable in aqueous solution and rapidly hydrolyzes into inorganic phosphate. Pyrophosphate is an osteotoxin (arrests bone development) and an arthritogen (promotes arthritis). It is also a metabotoxin (an endogenously produced metabolite that causes adverse health affects at chronically high levels). Chronically high levels of pyrophosphate are associated with hypophosphatasia. Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Hypophosphatasia is associated with a molecular defect in the gene encoding tissue non-specific alkaline phosphatase (TNSALP). TNSALP is an enzyme that is tethered to the outer surface of osteoblasts and chondrocytes. TNSALP hydrolyzes several substances, including inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate (PLP), a major form of vitamin B6. When TSNALP is low, inorganic pyrophosphate (PPi) accumulates outside of cells and inhibits the formation of hydroxyapatite, one of the main components of bone, causing rickets in infants and children and osteomalacia (soft bones) in adults. Vitamin B6 must be dephosphorylated by TNSALP before it can cross the cell membrane. Vitamin B6 deficiency in the brain impairs synthesis of neurotransmitters which can cause seizures. In some cases, a build-up of calcium pyrophosphate dihydrate crystals in the joints can cause pseudogout.
14000-31-8
C00013
644102
18361
PPI
559142
DB04160
[O-]P([O-])(=O)OP([O-])([O-])=O
O7P2
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-4
XPPKVPWEQAFLFU-UHFFFAOYSA-J
(phosphonooxy)phosphonic acid
173.9433
173.911925378
4
pyrophosphoric acid
0
-3
FDB021918
(4-)diphosphoric acid ion;(p2o74-)diphosphate;Diphosphate;Diphosphoric acid;Ppi;Pyrometaphosphate;Pyrophosphate;Pyrophosphate tetraanion;Pyrophosphate(4-) ion;[o3popo3](4-);Diphosphat;P2o7(4-);Pyrophosphat;Pyrophosphate ion;Phosphonato phosphoric acid;Pyrophosphoric acid;Pyrophosphoric acid ion
PW_C000170
Ppi
12
2
35
4
63
8
429
23
735
32
882
22
1217
3
1620
49
2410
59
2815
29
4175
14
4868
54
5034
89
5252
104
5294
101
5409
117
5424
103
5433
118
5458
120
5548
111
5559
132
5584
133
5606
135
5655
108
5879
107
6239
166
6978
199
7073
188
7134
163
7272
160
7312
198
7318
213
8275
151
8283
210
11869
161
12002
222
12041
164
12315
225
12323
249
12512
288
12579
226
12695
290
15219
306
15375
18
34760
17
42561
315
42697
318
77235
329
77317
128
77635
336
78416
335
78928
331
79153
112
79950
134
79958
130
80047
372
80417
170
85630
1
94786
384
94814
125
94819
382
98678
223
110634
391
113270
395
113275
389
115527
136
115532
399
119934
122
120017
124
120032
406
120330
410
120936
407
121261
429
121341
121
121486
383
122407
422
122985
444
123502
119
123831
464
124044
398
124977
375
125324
297
125395
299
125410
479
125597
484
125656
485
125876
481
126552
491
126869
205
126935
388
126950
501
127337
206
128124
508
1005
Zinc (II) ion
HMDB0001303
Zinc is an essential element, necessary for sustaining all life.Physiologically, it exists as an ion in the body. It is estimated that 3000 of the hundreds of thousands of proteins in the human body contain zinc prosthetic groups. In addition, there are over a dozen types of cells in the human body that secrete zinc ions, and the roles of these secreted zinc signals in medicine and health are now being actively studied. Intriguingly, brain cells in the mammalian forebrain are one type of cell that secretes zinc, along with its other neuronal messenger substances. Cells in the salivary gland, prostate, immune system and intestine are other types that secrete zinc. Obtaining a sufficient zinc intake during pregnancy and in young children is a problem, especially among those who cannot afford a good and varied diet. Brain development is stunted by zinc deficiency in utero and in youth. Zinc is an activator of certain enzymes, such as carbonic anhydrase. Carbonic anhydrase is important in the transport of carbon dioxide in vertebrate blood. Even though zinc is an essential requirement for a healthy body, too much zinc can be harmful. Excessive absorption of zinc can also suppress copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model (FIAM) is well-established in the literature, and shows that just micromolar amounts of the free ion kills some organisms.
23713-49-7
C00038
32051
29105
ZN%2b2
29723
DB01593
[Zn++]
Zn
InChI=1S/Zn/q+2
PTFCDOFLOPIGGS-UHFFFAOYSA-N
zinc(2+) ion
65.409
63.929146578
0
zinc(2+) ion
2
2
FDB003729
Zinc;Zinc ion;Dietary zinc;Zinc cation;Zinc, ion (zn2+);Zn(ii);Zn(2+);Zn2+
PW_C001005
Zinc
13
2
38
4
118
8
271
16
529
15
2957
51
3044
68
3120
29
3147
70
5410
117
5425
103
5434
118
5459
120
5560
132
5585
133
5598
135
7449
166
11787
198
12466
226
12724
290
13321
151
76967
225
77401
111
77580
114
77929
336
80400
1
120020
124
120035
406
120060
122
120441
409
121257
429
123075
137
123827
464
125398
299
125413
479
125438
297
125685
483
126938
388
126953
501
126976
205
127180
208
490
mRNA
NucleicAcid
NucleicAcid
PW_EC000490
mRNA
2
L-Alanyl-tRNA(Ala)
RNA
PW_NA000002
17732
LATA
2
2
37
4
1835
8
5413
117
5428
103
5437
118
5462
120
5563
132
5588
133
120019
124
120034
406
125397
299
125412
479
126937
388
126952
501
133709
111
133821
122
133868
135
2977
2
12
8
true
1260
2206
14
150
nucleic_acid
regular
150
70
1
tRNA(Ala)
DNA
PW_NA000001
29170
TRNAALA
1
2
36
4
1834
8
5412
117
5427
103
5436
118
5461
120
5562
132
5587
133
11910
278
120018
124
120033
406
125396
299
125411
479
126936
388
126951
501
133710
111
133822
122
133869
135
137071
651
8096
60S ribosomal protein L3
P39023
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
RPL3
1
133190
8
8109
60S ribosomal protein L4
P36578
RPL4
1
133191
8
8111
60S ribosomal protein L5
P46777
Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.
RPL5
1
133192
8
8112
60S ribosomal protein L6
Q02878
Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
RPL6
1
133193
8
8114
60S ribosomal protein L7a
P62424
RPL7A
1
133194
8
8113
60S ribosomal protein L7
P18124
Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
RPL7
1
133195
8
8115
60S ribosomal protein L8
P62917
RPL8
1
133196
8
8116
60S ribosomal protein L9
P32969
RPL9
1
133197
8
8077
60S ribosomal protein L10a
P62906
RPL10A
1
133198
8
8076
60S ribosomal protein L10
P27635
RPL10
1
133199
8
8078
60S ribosomal protein L11
P62913
Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).
RPL11
1
133200
8
8079
60S ribosomal protein L12
P30050
Binds directly to 26S ribosomal RNA.
RPL12
1
133201
8
8081
60S ribosomal protein L13a
P40429
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
RPL13A
1
133202
8
8080
60S ribosomal protein L13
P26373
RPL13
1
133203
8
8082
60S ribosomal protein L14
P50914
RPL14
1
133204
8
8083
60S ribosomal protein L15
P61313
RPL15
1
133205
8
8084
60S ribosomal protein L17
P18621
RPL17
1
133206
8
8086
60S ribosomal protein L18a
Q02543
RPL18A
1
133207
8
8085
60S ribosomal protein L18
Q07020
RPL18
1
133208
8
8087
60S ribosomal protein L19
P84098
RPL19
1
133209
8
8088
60S ribosomal protein L21
P46778
RPL21
1
133210
8
4811
60S ribosomal protein L22
P35268
HMDBP10729
RPL22
1p36.31
BC035566
1
133211
8
8090
60S ribosomal protein L23a
P62750
This protein binds to a specific region on the 26S rRNA.
RPL23A
1
133212
8
8089
60S ribosomal protein L23
P62829
RPL23
1
133213
8
8091
60S ribosomal protein L24
P83731
RPL24
1
133214
8
8092
60S ribosomal protein L26
P61254
RPL26
1
133215
8
8094
60S ribosomal protein L27a
P46776
RPL27A
1
133216
8
8093
60S ribosomal protein L27
P61353
RPL27
1
133217
8
8095
60S ribosomal protein L28
P46779
RPL28
1
133218
8
4810
60S ribosomal protein L29
P47914
HMDBP10728
RPL29
3p21.3-p21.2
AK311884
1
133219
8
8097
60S ribosomal protein L30
P62888
RPL30
1
133220
8
8098
60S ribosomal protein L31
P62899
RPL31
1
133221
8
8099
60S ribosomal protein L32
P62910
RPL32
1
133222
8
8100
60S ribosomal protein L34
P49207
RPL34
1
133223
8
8102
60S ribosomal protein L35a
P18077
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.
RPL35A
1
133224
8
8101
60S ribosomal protein L35
P42766
RPL35
1
133225
8
8104
60S ribosomal protein L36a
P83881
RPL36A
1
133226
8
8103
60S ribosomal protein L36
Q9Y3U8
RPL36
1
133227
8
8106
60S ribosomal protein L37a
P61513
RPL37A
1
133228
8
8105
60S ribosomal protein L37
P61927
Binds to the 23S rRNA.
RPL37
1
133229
8
8107
60S ribosomal protein L38
P63173
RPL38
1
133230
8
8108
60S ribosomal protein L39
P62891
RPL39
1
133231
8
8120
Ubiquitin-60S ribosomal protein L40
P62987
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
UBA52
1
133232
8
8110
60S ribosomal protein L41
P62945
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.
RPL41
1
133233
8
8117
60S acidic ribosomal protein P0
P05388
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
RPLP0
1
133234
8
8118
60S acidic ribosomal protein P1
P05386
Plays an important role in the elongation step of protein synthesis.
RPLP1
1
133235
8
8119
60S acidic ribosomal protein P2
P05387
Plays an important role in the elongation step of protein synthesis.
RPLP2
1
133236
8
8043
40S ribosomal protein S2
P15880
RPS2
1
133237
8
8053
40S ribosomal protein S3
P23396
Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).
RPS3
1
4.2.99.18
133238
8
8054
40S ribosomal protein S3a
P61247
May play a role during erythropoiesis through regulation of transcription factor DDIT3.
RPS3A
1
133239
8
8055
40S ribosomal protein S4, X isoform
P62701
RPS4X
1
133240
8
8056
40S ribosomal protein S5
P46782
RPS5
1
133241
8
8057
40S ribosomal protein S6
P62753
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
RPS6
1
133242
8
8058
40S ribosomal protein S7
P62081
Required for rRNA maturation.
RPS7
1
133243
8
8059
40S ribosomal protein S8
P62241
RPS8
1
133244
8
8060
40S ribosomal protein S9
P46781
RPS9
1
133245
8
8032
40S ribosomal protein S10
P46783
Component of the 40S ribosomal subunit.
RPS10
1
133246
8
8033
40S ribosomal protein S11
P62280
RPS11
1
133247
8
8034
40S ribosomal protein S12
P25398
RPS12
1
133248
8
8035
40S ribosomal protein S13
P62277
RPS13
1
133249
8
8036
40S ribosomal protein S14
P62263
RPS14
1
133250
8
8037
40S ribosomal protein S15
P62841
RPS15
1
133251
8
8038
40S ribosomal protein S15a
P62244
RPS15A
1
133252
8
8039
40S ribosomal protein S16
P62249
RPS16
1
133253
8
8040
40S ribosomal protein S17
P08708
RPS17
1
133254
8
8041
40S ribosomal protein S18
P62269
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
RPS18
1
133255
8
8042
40S ribosomal protein S19
P39019
Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
RPS19
1
133256
8
8044
40S ribosomal protein S20
P60866
RPS20
1
133257
8
8045
40S ribosomal protein S21
P63220
RPS21
1
133258
8
8046
40S ribosomal protein S23
P62266
RPS23
1
133259
8
8047
40S ribosomal protein S24
P62847
Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.
RPS24
1
133260
8
8048
40S ribosomal protein S25
P62851
RPS25
1
133261
8
8049
40S ribosomal protein S26
P62854
RPS26
1
133262
8
3391
40S ribosomal protein S27
P42677
HMDBP08171
RPS27
1q21
CH471121
1
133263
8
8051
40S ribosomal protein S28
P62857
RPS28
1
133264
8
8052
40S ribosomal protein S29
P62273
RPS29
1
133265
8
8031
40S ribosomal protein S30
P62861
FAU
1
133266
8
8061
40S ribosomal protein SA
P08865
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
RPSA
1
133267
8
8840
Receptor of activated protein C kinase 1
P63244
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).
RACK1
1
133268
8
592
Alanine--tRNA ligase, cytoplasmic
P49588
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
HMDBP00625
AARS
16q22
AC012184
1
6.1.1.7
14
2
1836
8
4755
Alanine--tRNA ligase, mitochondrial
Q5JTZ9
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
HMDBP10671
AARS2
6p21.1
BC131728
1
6.1.1.7
39
4
133690
8
11001
Large 60S Ribosomal Subunit
1
PW_P011001
19588
8096
20243
8109
20244
8111
20252
8112
20253
8114
20254
8113
20255
8115
20256
8116
20257
8077
20258
8076
20259
8078
20260
8079
20261
8081
20262
8080
20263
8082
20264
8083
20265
8084
20266
8086
20267
8085
20268
8087
20269
8088
20281
4811
20282
8090
20283
8089
20287
8091
20289
8092
20290
8094
20306
8093
20307
8095
20308
4810
20309
8097
20310
8098
20311
8099
20312
8100
20313
8102
20314
8101
20315
8104
20316
8103
20317
8106
20318
8105
20333
8107
20334
8108
20335
8120
20336
8110
20337
8117
20338
8118
20339
8119
11454
Small 40S Ribosomal Subunit
1
PW_P011454
20347
8043
20349
8053
20350
8054
20351
8055
20352
8056
20353
8057
20354
8058
20355
8059
20356
8060
20357
8032
20358
8033
20359
8034
20360
8035
20361
8036
20362
8037
20363
8038
20395
8039
20396
8040
20397
8041
20398
8042
20399
8044
20400
8045
20401
8046
20402
8047
20403
8048
20404
8049
20405
3391
20406
8051
20407
8052
20408
8031
20409
8061
20410
8840
1
Alanine--tRNA ligase, cytoplasmic
1
PW_P000001
1
592
1
1
1005
1
3
2
4
Alanine--tRNA ligase, mitochondrial
1
PW_P000004
5
4755
1
4
1005
7
3
178631
PW_R178631
Right
674141
2
1
NucleicAcid
false
674142
222
1
Bound
false
674143
223
1
Bound
false
1
false
PW_R000001
Right
1
414
1
Compound
true
2
105
1
Compound
false
3
1
1
NucleicAcid
true
4
32
1
Compound
true
5
170
1
Compound
true
6
2
1
NucleicAcid
false
5
4
6.1.1.7
168801
1
879
222
8
101140
171
11776
3563194
1364
779979
3563195
1365
779980
3563196
880
223
8
101140
172
11777
3563198
5
2977
3563199
1366
779981
3563200
1367
779982
3563201
2406118
414
8
42
false
335
702
10
regular
50
30
2406119
105
8
3
false
295
412
10
regular
100
100
2406120
32
8
44
false
645
700
10
regular
50
30
2406121
170
8
45
false
638
465
10
regular
63
43
2649666
1005
8
9
false
472
557
10
regular
100
25
11776
490
145
8
true
780
2206
12
regular
150
70
11777
490
37
8
true
1170
2206
12
regular
100
90
2611
1
96
8
false
225
577
14
120
nucleic_acid
regular
120
115
2612
2
96
8
false
690
579
14
120
nucleic_acid
regular
120
115
2977
2
12
8
true
1260
2206
14
150
nucleic_acid
regular
150
70
897294
8096
8
2
true
640
2206
8
subunit
regular
150
70
897295
8109
8
2
true
640
2266
8
subunit
regular
150
70
897296
8111
8
2
true
640
2326
8
subunit
regular
150
70
897297
8112
8
2
true
640
2386
8
subunit
regular
150
70
897298
8114
8
2
true
640
2446
8
subunit
regular
150
70
897299
8113
8
2
true
640
2506
8
subunit
regular
150
70
897300
8115
8
2
true
640
2566
8
subunit
regular
150
70
897301
8116
8
2
true
640
2626
8
subunit
regular
150
70
897302
8077
8
2
true
640
2686
8
subunit
regular
150
70
897303
8076
8
2
true
640
2746
8
subunit
regular
150
70
897304
8078
8
2
true
640
2806
8
subunit
regular
150
70
897305
8079
8
2
true
640
2866
8
subunit
regular
150
70
897306
8081
8
2
true
640
2926
8
subunit
regular
150
70
897307
8080
8
2
true
640
2986
8
subunit
regular
150
70
897308
8082
8
2
true
640
3046
8
subunit
regular
150
70
897309
8083
8
2
true
640
3106
8
subunit
regular
150
70
897310
8084
8
2
true
640
3166
8
subunit
regular
150
70
897311
8086
8
2
true
640
3226
8
subunit
regular
150
70
897312
8085
8
2
true
640
3286
8
subunit
regular
150
70
897313
8087
8
2
true
640
3346
8
subunit
regular
150
70
897314
8088
8
2
true
640
3406
8
subunit
regular
150
70
897315
4811
8
2
true
640
3466
8
subunit
regular
150
70
897316
8090
8
2
true
640
3526
8
subunit
regular
150
70
897317
8089
8
2
true
640
3586
8
subunit
regular
150
70
897318
8091
8
2
true
640
3646
8
subunit
regular
150
70
897319
8092
8
2
true
640
3706
8
subunit
regular
150
70
897320
8094
8
2
true
640
3766
8
subunit
regular
150
70
897321
8093
8
2
true
640
3826
8
subunit
regular
150
70
897322
8095
8
2
true
640
3886
8
subunit
regular
150
70
897323
4810
8
2
true
640
3946
8
subunit
regular
150
70
897324
8097
8
2
true
640
4006
8
subunit
regular
150
70
897325
8098
8
2
true
640
4066
8
subunit
regular
150
70
897326
8099
8
2
true
640
4126
8
subunit
regular
150
70
897327
8100
8
2
true
640
4186
8
subunit
regular
150
70
897328
8102
8
2
true
640
4246
8
subunit
regular
150
70
897329
8101
8
2
true
640
4306
8
subunit
regular
150
70
897330
8104
8
2
true
640
4366
8
subunit
regular
150
70
897331
8103
8
2
true
640
4426
8
subunit
regular
150
70
897332
8106
8
2
true
640
4486
8
subunit
regular
150
70
897333
8105
8
2
true
640
4546
8
subunit
regular
150
70
897334
8107
8
2
true
640
4606
8
subunit
regular
150
70
897335
8108
8
2
true
640
4666
8
subunit
regular
150
70
897336
8120
8
2
true
640
4726
8
subunit
regular
150
70
897337
8110
8
2
true
640
4786
8
subunit
regular
150
70
897338
8117
8
2
true
640
4846
8
subunit
regular
150
70
897339
8118
8
2
true
640
4906
8
subunit
regular
150
70
897340
8119
8
2
true
640
4966
8
subunit
regular
150
70
897341
8043
8
2
true
640
5026
8
subunit
regular
150
70
897342
8053
8
2
true
640
5086
8
subunit
regular
150
70
897343
8054
8
2
true
640
5146
8
subunit
regular
150
70
897344
8055
8
2
true
640
5206
8
subunit
regular
150
70
897345
8056
8
2
true
640
5266
8
subunit
regular
150
70
897346
8057
8
2
true
640
5326
8
subunit
regular
150
70
897347
8058
8
2
true
640
5386
8
subunit
regular
150
70
897348
8059
8
2
true
640
5446
8
subunit
regular
150
70
897349
8060
8
2
true
640
5506
8
subunit
regular
150
70
897350
8032
8
2
true
640
5566
8
subunit
regular
150
70
897351
8033
8
2
true
640
5626
8
subunit
regular
150
70
897352
8034
8
2
true
640
5686
8
subunit
regular
150
70
897353
8035
8
2
true
640
5746
8
subunit
regular
150
70
897354
8036
8
2
true
640
5806
8
subunit
regular
150
70
897355
8037
8
2
true
640
5866
8
subunit
regular
150
70
897356
8038
8
2
true
640
5926
8
subunit
regular
150
70
897357
8039
8
2
true
640
5986
8
subunit
regular
150
70
897358
8040
8
2
true
640
6046
8
subunit
regular
150
70
897359
8041
8
2
true
640
6106
8
subunit
regular
150
70
897360
8042
8
2
true
640
6166
8
subunit
regular
150
70
897361
8044
8
2
true
640
6226
8
subunit
regular
150
70
897362
8045
8
2
true
640
6286
8
subunit
regular
150
70
897363
8046
8
2
true
640
6346
8
subunit
regular
150
70
897364
8047
8
2
true
640
6406
8
subunit
regular
150
70
897365
8048
8
2
true
640
6466
8
subunit
regular
150
70
897366
8049
8
2
true
640
6526
8
subunit
regular
150
70
897367
3391
8
2
true
640
6586
8
subunit
regular
150
70
897368
8051
8
2
true
640
6646
8
subunit
regular
150
70
897369
8052
8
2
true
640
6706
8
subunit
regular
150
70
897370
8031
8
2
true
640
6766
8
subunit
regular
150
70
897371
8061
8
2
true
640
6826
8
subunit
regular
150
70
897372
8840
8
2
true
640
6886
8
subunit
regular
150
70
897373
8096
8
188
false
1030
596
2
none
regular
300
140
897374
8109
8
136
true
1220
436
8
protein
regular
175
155
897375
8111
8
136
true
1030
596
8
protein
regular
175
155
897376
8112
8
2
true
1030
2386
8
subunit
regular
150
70
897377
8114
8
2
true
1030
2446
8
subunit
regular
150
70
897378
8113
8
2
true
1030
2506
8
subunit
regular
150
70
897379
8115
8
2
true
1030
2566
8
subunit
regular
150
70
897380
8116
8
2
true
1030
2626
8
subunit
regular
150
70
897381
8077
8
2
true
1030
2686
8
subunit
regular
150
70
897382
8076
8
2
true
1030
2746
8
subunit
regular
150
70
897383
8078
8
2
true
1030
2806
8
subunit
regular
150
70
897384
8079
8
2
true
1030
2866
8
subunit
regular
150
70
897385
8081
8
2
true
1030
2926
8
subunit
regular
150
70
897386
8080
8
2
true
1030
2986
8
subunit
regular
150
70
897387
8082
8
2
true
1030
3046
8
subunit
regular
150
70
897388
8083
8
2
true
1030
3106
8
subunit
regular
150
70
897389
8084
8
2
true
1030
3166
8
subunit
regular
150
70
897390
8086
8
2
true
1030
3226
8
subunit
regular
150
70
897391
8085
8
2
true
1030
3286
8
subunit
regular
150
70
897392
8087
8
2
true
1030
3346
8
subunit
regular
150
70
897393
8088
8
2
true
1030
3406
8
subunit
regular
150
70
897394
4811
8
2
true
1030
3466
8
subunit
regular
150
70
897395
8090
8
2
true
1030
3526
8
subunit
regular
150
70
897396
8089
8
2
true
1030
3586
8
subunit
regular
150
70
897397
8091
8
2
true
1030
3646
8
subunit
regular
150
70
897398
8092
8
2
true
1030
3706
8
subunit
regular
150
70
897399
8094
8
2
true
1030
3766
8
subunit
regular
150
70
897400
8093
8
2
true
1030
3826
8
subunit
regular
150
70
897401
8095
8
2
true
1030
3886
8
subunit
regular
150
70
897402
4810
8
2
true
1030
3946
8
subunit
regular
150
70
897403
8097
8
2
true
1030
4006
8
subunit
regular
150
70
897404
8098
8
2
true
1030
4066
8
subunit
regular
150
70
897405
8099
8
2
true
1030
4126
8
subunit
regular
150
70
897406
8100
8
2
true
1030
4186
8
subunit
regular
150
70
897407
8102
8
2
true
1030
4246
8
subunit
regular
150
70
897408
8101
8
2
true
1030
4306
8
subunit
regular
150
70
897409
8104
8
2
true
1030
4366
8
subunit
regular
150
70
897410
8103
8
2
true
1030
4426
8
subunit
regular
150
70
897411
8106
8
2
true
1030
4486
8
subunit
regular
150
70
897412
8105
8
2
true
1030
4546
8
subunit
regular
150
70
897413
8107
8
2
true
1030
4606
8
subunit
regular
150
70
897414
8108
8
2
true
1030
4666
8
subunit
regular
150
70
897415
8120
8
2
true
1030
4726
8
subunit
regular
150
70
897416
8110
8
2
true
1030
4786
8
subunit
regular
150
70
897417
8117
8
2
true
1030
4846
8
subunit
regular
150
70
897418
8118
8
2
true
1030
4906
8
subunit
regular
150
70
897419
8119
8
2
true
1030
4966
8
subunit
regular
150
70
897420
8043
8
186
false
1050
766
2
none
regular
150
70
897421
8053
8
186
false
1175
766
2
none
regular
150
70
897422
8054
8
2
true
1030
5146
8
subunit
regular
150
70
897423
8055
8
2
true
1030
5206
8
subunit
regular
150
70
897424
8056
8
2
true
1030
5266
8
subunit
regular
150
70
897425
8057
8
2
true
1030
5326
8
subunit
regular
150
70
897426
8058
8
2
true
1030
5386
8
subunit
regular
150
70
897427
8059
8
2
true
1030
5446
8
subunit
regular
150
70
897428
8060
8
2
true
1030
5506
8
subunit
regular
150
70
897429
8032
8
2
true
1030
5566
8
subunit
regular
150
70
897430
8033
8
2
true
1030
5626
8
subunit
regular
150
70
897431
8034
8
2
true
1030
5686
8
subunit
regular
150
70
897432
8035
8
2
true
1030
5746
8
subunit
regular
150
70
897433
8036
8
2
true
1030
5806
8
subunit
regular
150
70
897434
8037
8
2
true
1030
5866
8
subunit
regular
150
70
897435
8038
8
2
true
1030
5926
8
subunit
regular
150
70
897436
8039
8
2
true
1030
5986
8
subunit
regular
150
70
897437
8040
8
2
true
1030
6046
8
subunit
regular
150
70
897438
8041
8
2
true
1030
6106
8
subunit
regular
150
70
897439
8042
8
2
true
1030
6166
8
subunit
regular
150
70
897440
8044
8
2
true
1030
6226
8
subunit
regular
150
70
897441
8045
8
2
true
1030
6286
8
subunit
regular
150
70
897442
8046
8
2
true
1030
6346
8
subunit
regular
150
70
897443
8047
8
2
true
1030
6406
8
subunit
regular
150
70
897444
8048
8
2
true
1030
6466
8
subunit
regular
150
70
897445
8049
8
2
true
1030
6526
8
subunit
regular
150
70
897446
3391
8
2
true
1030
6586
8
subunit
regular
150
70
897447
8051
8
2
true
1030
6646
8
subunit
regular
150
70
897448
8052
8
2
true
1030
6706
8
subunit
regular
150
70
897449
8031
8
2
true
1030
6766
8
subunit
regular
150
70
897450
8061
8
2
true
1030
6826
8
subunit
regular
150
70
897451
8840
8
2
true
1030
6886
8
subunit
regular
150
70
914543
592
8
2
false
447
572
8
subunit
regular
150
70
779979
11001
101140
8
894387
897294
894388
897295
894389
897296
894390
897297
894391
897298
894392
897299
894393
897300
894394
897301
894395
897302
894396
897303
894397
897304
894398
897305
894399
897306
894400
897307
894401
897308
894402
897309
894403
897310
894404
897311
894405
897312
894406
897313
894407
897314
894408
897315
894409
897316
894410
897317
894411
897318
894412
897319
894413
897320
894414
897321
894415
897322
894416
897323
894417
897324
894418
897325
894419
897326
894420
897327
894421
897328
894422
897329
894423
897330
894424
897331
894425
897332
894426
897333
894427
897334
894428
897335
894429
897336
894430
897337
894431
897338
894432
897339
894433
897340
779980
11454
101140
8
894434
897341
894435
897342
894436
897343
894437
897344
894438
897345
894439
897346
894440
897347
894441
897348
894442
897349
894443
897350
894444
897351
894445
897352
894446
897353
894447
897354
894448
897355
894449
897356
894450
897357
894451
897358
894452
897359
894453
897360
894454
897361
894455
897362
894456
897363
894457
897364
894458
897365
894459
897366
894460
897367
894461
897368
894462
897369
894463
897370
894464
897371
894465
897372
779981
11001
101140
8
894466
897373
894467
897374
894468
897375
894469
897376
894470
897377
894471
897378
894472
897379
894473
897380
894474
897381
894475
897382
894476
897383
894477
897384
894478
897385
894479
897386
894480
897387
894481
897388
894482
897389
894483
897390
894484
897391
894485
897392
894486
897393
894487
897394
894488
897395
894489
897396
894490
897397
894491
897398
894492
897399
894493
897400
894494
897401
894495
897402
894496
897403
894497
897404
894498
897405
894499
897406
894500
897407
894501
897408
894502
897409
894503
897410
894504
897411
894505
897412
894506
897413
894507
897414
894508
897415
894509
897416
894510
897417
894511
897418
894512
897419
779982
11454
101140
8
894513
897420
894514
897421
894515
897422
894516
897423
894517
897424
894518
897425
894519
897426
894520
897427
894521
897428
894522
897429
894523
897430
894524
897431
894525
897432
894526
897433
894527
897434
894528
897435
894529
897436
894530
897437
894531
897438
894532
897439
894533
897440
894534
897441
894535
897442
894536
897443
894537
897444
894538
897445
894539
897446
894540
897447
894541
897448
894542
897449
894543
897450
894544
897451
790224
1
101140
8
911057
914543
31096
2649666
3606143
Cofactor
3274846
M345 412 C345 382 345 342 345 312
5
false
18
true
M 492.5 587.0096189432334 L 500 600 L 507.5 587.0096189432334
false
3563193
M805 609 C918 649 969 670 1149 740
5
false
18
true
M 888.9749045598433 581.96644186147 L 901 573 L 887.2222858463324 567.0691827966269
false
3563194
M775 2201 L775 2251 L825 2201 z
10
true
18
3563195
M412 2424 L412 2474 L462 2424 z
10
true
18
3563196
M412 5244 L412 5294 L462 5244 z
10
true
18
3563197
M1148 731 C1016 679 1032 680 885 630
5
true
18
true
M 931.4910742126166 2889.5198868142757 L 945 2883 L 932.5991494953463 2874.560870497425
false
3563198
M1165 2201 L1165 2251 L1215 2201 z
10
true
18
3563199
M1255 2201 L1255 2251 L1305 2201 z
10
true
18
3563200
M412 2814 L412 2864 L462 2814 z
10
true
18
3563201
M412 5634 L412 5684 L462 5634 z
10
true
18
3563202
M1260 2241 C1230 2241 835 609 805 609
5
true
18
true
M 386.94685504416486 371.261556296296 L 372 370 L 378.38088772118584 383.5751343230783
false
3606137
M385 717 C389 641 417 607 447 607
5
false
18
3606138
M395 462 C394 565 417 607 447 607
5
false
18
3606139
M645 715 C646 651 627 607 597 607
5
false
18
true
M 25.946855044164835 357.261556296296 L 11 356 L 17.380887721185843 369.5751343230783
false
3606140
M638 486.5 C638 567.5 627 607 597 607
5
false
18
true
M 25.946855044164835 357.261556296296 L 11 356 L 17.380887721185843 369.5751343230783
false
3606141
M340 607 C370 607 417 607 447 607
5
false
18
3606142
M695 609 C665 609 627 607 597 607
5
false
18
true
M 25.946855044164835 357.261556296296 L 11 356 L 17.380887721185843 369.5751343230783
false
3606143
M422.25 542 L422.25 592 L472.25 542 z
10
true
18
780712
101140
178631
8
615
879
3563197
Left
616
880
3563202
Right
927
2612
3563193
Left
788427
101140
1
8
3192336
2406118
3606137
Left
3192337
2406119
3606138
Left
3192338
2406120
3606139
Right
3192339
2406121
3606140
Right
1174
2611
3606141
Left
1175
2612
3606142
Right
745182
168801
790224
93706
94226
101140
14
false
270
242
16
regular
90580
2406119
3274846
Right
160487
685
172
0.4
0.4
0
1
42
1785
1645
333339
M128 226.5 C128 176.5 178 126.5 228 126.5 C576 126.5 1028 126.5 1376 126.5 C1426 126.5 1476 176.5 1476 226.5 C1476 419.5 1476 669.5 1476 862.5 C1476 912.5 1426 962.5 1376 962.5 C1028 962.5 576 962.5 228 962.5 C178 962.5 128 912.5 128 862.5 C128 669.5 128 419.5 128 226.5
1
true
6
0.0
0.0
406803
15
mRNA
595
746
20
1.3
1.3
160
15
406804
15
Polypeptide Chain
885
442
20
1.3
1.3
160
15
406805
235
Translation
1021
799
20
1.6
1.6
200
15
406806
15
Ribosome
1242
580
20
1.3
1.3
160
15
407398
15
Cytoplasm
1207
173
20
1.3
1.3
160
15