Quantitative metabolomics services for biomarker discovery and validation.
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Protein kinase A Protein kinase A Protein kinase A Protein kinase A Protein kinase A Protein kinase A Protein kinase A D(2) dopamine receptor Adenylate cyclase type 2 Guanine nucleotide- binding protein alpha Guanine nucleotide- binding protein G(i) subunit alpha-1 Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Sodium- dependent dopamine transporter Aromatic-L- amino-acid decarboxylase cAMP Ca+ Dopamine Dopamine Dopamine Ca+ L-Dopa L-Dopa L-Dopa CO2 ATP PPi Na+ Na+ Pyridoxal 5'-phosphate Neuronal Excitability Magnesium Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Synapse Blood Brain Barrier Brain Levodopa is taken orally and absorbed from the gastrointestinal tract. Diffusion Levodopa diffuses across the blood-brain barrier and into the neuron where it is converted into Dopamine. L-Dopa causes a higher concentration of dopamine in the synapse in the brain, activating dopamine receptors more.
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 DDC cAMP Calcium Dopamine Dopamine Dopamine Calcium L-Dopa L-Dopa L-Dopa Carbon dioxide Adenosine triphosphate Pyrophosphate Sodium Sodium Neuronal Excitability
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 DDC cAMP Ca+ LDP LDP LDP Ca+ L-Dopa L-Dopa L-Dopa CO2 ATP PPi Na+ Na+ Pyr-5'P Neu Exc Mg2+ Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Synapse Blood Brain Barrier Brain Levodopa is taken orally and absorbed from the gastrointestinal tract. Diffusion Levodopa diffuses across the blood-brain barrier and into the neuron where it is converted into Dopamine. L-Dopa causes a higher concentration of dopamine in the synapse in the brain, activating dopamine receptors more.
PRKAR2B PRKACA PRKACB PRKAR1A PRKACG PRKAR1B PRKAR2A DRD2 ADCY2 GNAS GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 DDC cAMP Ca2+ LDP LDP LDP Ca2+ L-Dopa L-Dopa L-Dopa CO2 ATP Ppi Na+ Na+ Neu Exc